muramidase and Pharyngitis

The efficacy of two commercially available throat lozenges (test preparation with lysozyme, papain and bacitracin as active ingredients, comparative preparation with a disinfectant only) has been tested under conditions of a randomized clinical study. Two groups of 50 patients each with the indications pharyngitis and/or tonsillitis, acute or subacute, have been compared under the conditions of an ENT-practice. The efficacy of the test preparation was established by the general amelioration evaluated by physician and patient and the symptoms reddening, swelling and coating of the throat, pain on swallowing and hoarseness, swelling and pain of lymph nodes. It is supposed that this superiority is due to the enzyme lysozyme and papain in the test preparation.

Topics: Adult; Anti-Infective Agents, Local; Bacitracin; Drug Therapy, Combination; Female; Hoarseness; Humans; Male; Muramidase; Papain; Pharyngitis; Tonsillitis

Topics: Anti-Infective Agents; Drug Combinations; Humans; Muramidase; Papain; Pharyngitis; Tonsillitis

In a controlled clinical trial Frubienzym (throat lozenges with 5 mg lysozyme, 2 mg papaine and 200 I.U. bacitracin) or placebo have been given to 100 patients with pharyngitis and/or tonsillitis for 4 days. Under treatment with Frubienzym reddening, swelling, matter and mucus in the throat, coughing, swelling and pain of lymphatic ganglions and pain of swallowing vanished more quickly than under placebo. The differences were significant (p less than 0,05, p less than 0,001 or even p less than 0,001; U-test of Wilcoxon, Man and Whitney). There were no side effects which could be attributed to Frubienzym.

Topics: Acute Disease; Adult; Bacitracin; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Humans; Male; Muramidase; Papain; Pharyngitis; Tonsillitis

Topics: Anti-Infective Agents, Local; Bacitracin; Cetylpyridinium; Clinical Trials as Topic; Drug Combinations; Humans; Mouth Diseases; Muramidase; Papain; Pharyngitis

This study aimed to evaluate the efficacy and safety of lysozyme-based oral antiseptic in the therapy of non-infectious sore throat in teachers.. A non-interventional, prospective, pilot study was conducted with two examinations. The first was performed as part of a general medical examination. If a non-infectious sore throat was confirmed by clinical checkup and all other inclusion and non-exclusion criteria confirmed, patients were offered to be enrolled in the study. After signing the informed consent form, patients were advised to use lysozyme-based lozenges, six times a day, for a period of five days. A telephone call follow-up examination was performed within 24 hours from the therapy completion.. This was a pilot study involving 25 adult patients of both genders. Lysozyme-based lozenges showed positive effects in relieving the symptoms of non-infectious sore throat in teachers. At the same time, the lozenges showed excellent tolerability, and no side effects were reported during the study. 92% of patients confirmed they would take the same medicine again due to the same problem.. The results of this "proof-of-concept" study indicated that lysozyme-based antiseptic could be effective and safe in the treatment of non-infectious sore throat in teachers and should be further evaluated as treatment option in this condition.

Topics: Administration, Oral; Adult; Anti-Infective Agents, Local; Double-Blind Method; Female; Humans; Male; Muramidase; Pharyngitis; Pilot Projects; Prospective Studies

Topics: Anti-Infective Agents; Humans; Muramidase; Pharyngitis

The objective of the present study was to elucidate the relationship between the activity of the interferon system at the local level and the frequency of the development of relapses of acute inflammation of pharyngeal mucosa. The secondary objective was to estimate the possibility, necessity, and efficacy of the correction of the abnormal local immune response with the use of immunomodulatory agents. A total of 45 patients presenting with acute pharyngitis were available for the examination. They were allocated to two groups comprised of 25 and 20 patients respectively. Those in group 1 were given Hexalyse, a composite preparation for the local application. The patients of group 2 were treated with Strepsils. The study included general and specialized otorhinological examination as well as the evaluation of interferon production at the local level by measuring (using immunoenzyme assay) the concentration of interferon-alpha in the saliva before and on days 3 and 5 after the initiation of therapy. It was shown that the adaptive mechanisms of pharyngeal mucosa in acute pharyngitis are realized through activation of the interferon system. Elimination of the inflammatory process was accompanied by normalization of interferon-alpha level in the saliva regardless of the therapeutic modality used. One third of the patients presenting with acute pharyngitis suffered insufficiency of interferon production. It is concluded that the inclusion of an immunomodulatory agent, such as Hexalyse, in the combined treatment of such patients activates biosynthesis of interferon-alpha and leads to the reduction in the frequency of relapses of the disease. The results of the study of the relationship between the concentration of interferon-alpha in the saliva, the duration of acute pharyngitis, and the frequency of its post-treatment relapses were used to develop the practical recommendations for the prescription of Hexalyse for the treatment of patients with this pathology.

Topics: Acute Disease; Adult; Anesthetics, Local; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Glycyrrhetinic Acid; Humans; Interferon-alpha; Lidocaine; Muramidase; Pharyngitis; Saliva; Severity of Illness Index; Treatment Outcome

A common complication of virus-induced upper respiratory tract infections is acute otitis media caused by bacterial pathogens. Simultaneously, increased bacterial colonization in the nasopharynx occurs. Our intention in this study was to identify the causes of this increased colonization of bacteria by evaluating their coating with the antibacterial substances lysozyme, lactoferrin and immunoglobulins IgG, S-IgA and IgM and their ability to penetrate epithelial cells during infectious mononucleosis (IM) caused by Epstein-Barr virus.. Cellular samples were collected from the oropharynx of 21 patients (16 males, five females; age range 10-21 years) with current IM. An immunocytochemical assay using gold-labelled antiserum to human lysozyme, lactoferrin, IgG, S-IgA and IgM followed by gold particle and epithelial cell tracing in the transmission electron microscope.. A significant reduction in bacterial coating with IgG (P<0.05) and S-IgA (P<0.01) was noted, whereas there was a significant increase in coating with lactoferrin (P<0.01) and IgM (P<0.01). No significant change in lysozyme coating of the bacteria was noted, compared with healthy controls. Bacterial penetration into epithelial cells was seen particularly in patients culture-positive for beta-haemolytic streptococci.. Reduced bacterial coating with IgG and S-IgA immunoglobulins, combined with bacterial penetration into epithelial cells, may exacerbate the bacterial colonization on oropharyngeal mucosal membranes observed during IM.

Topics: Acute Disease; Adolescent; Adult; Case-Control Studies; Child; Data Interpretation, Statistical; Epithelial Cells; Female; Herpesvirus 4, Human; Humans; Immunity, Mucosal; Immunoglobulin A, Secretory; Immunoglobulin G; Immunoglobulin M; Infectious Mononucleosis; Lactoferrin; Male; Microscopy, Electron; Muramidase; Nasal Mucosa; Nasopharynx; Otitis Media; Pharyngitis

Topics: Adult; Female; Humans; Lasers; Male; Middle Aged; Muramidase; Pharyngitis; Saliva; Stomatitis, Aphthous; Tonsillitis

Topics: Adult; Female; Humans; Lasers; Male; Middle Aged; Muramidase; Pharyngitis; Saliva; Stomatitis, Aphthous

Topics: Chronic Disease; Humans; Immunoglobulins; Muramidase; Pharyngitis

Local and humoral immunity factors have been studied in 152 patients with different forms of meningococcal infection. The peculiar pattern of the time course of changes in these factors, depending on the clinical form of the disease, has been revealed. In the generalized form of infection changes in the immunological characteristics of the saliva and blood serum (lysozyme, secretory immunoglobulin, immunoglobulins of the main classes and specific antimeningococcal antibodies) have been shown to be more essential than in the localized form.

Topics: Adolescent; Adult; Antibodies, Bacterial; Antibody Formation; Female; Humans; Immunity, Innate; Immunoglobulins; Male; Meningitis, Meningococcal; Meningococcal Infections; Muramidase; Nasopharyngitis; Pharyngitis; Polysaccharides, Bacterial; Saliva; Time Factors

Topics: Bacitracin; Drug Combinations; Drug Evaluation; Muramidase; Papain; Pharyngitis; Staphylococcal Infections; Streptococcal Infections; Tonsillitis

Topics: Bacitracin; Drug Combinations; Drug Evaluation; Female; Humans; Male; Muramidase; Papain; Pharyngitis; Tonsillitis