muramidase and Peptic-Ulcer

Find out the condition of mucosal microflora in gastroduodenal ulcer patients in different phases of its recurrence, to determine changes in the value of dysbiotic changes in ulcerogenesis, develop and confirm new transendoscopic treatment of gastroduodenal ulcers.. The study included 134 patients and 10 healthy volunteers. At relapse of peptic ulcer and distant from the ulcer areas of the mucosa were allocated to 28 genera and species of microorganisms with a wide range of enzymatic activity and cytotoxicity, that corresponds to the 2-3 degree dysbacteriosis and shows microbiological parameters infected wound which required sanation.. Application for transendoscopic sanation of gastroduodenal ulcers of new compounds iodine-lysozyme, dimexide-iodine-lysozyme and chitosan with bactericidal and sorption effects, can significantly reduce the time of ulcer healing and restore normobiocenosis of mucosal microflora of the gastroduodenal zone.

Topics: Anti-Infective Agents; Chitosan; Dimethyl Sulfoxide; Drug Delivery Systems; Endoscopy, Gastrointestinal; Gastric Mucosa; Humans; Intestinal Mucosa; Iodides; Muramidase; Peptic Ulcer; Wound Healing

Addition of splenocytokine therapy to combined therapy of peptic ulcer accelerated healing and prolonged remission.

Topics: Adult; Aged; Animals; Antimicrobial Cationic Peptides; Blood Proteins; Complement System Proteins; Cytokines; Endoscopy, Gastrointestinal; Female; Hemofiltration; Humans; Immunity, Cellular; Immunotherapy; Lymphocytes; Male; Middle Aged; Muramidase; Peptic Ulcer; Spleen; Sus scrofa; Tissue Extracts

The studies conducted for 126 patients with stomach and duodenal ulcers revealed that at the acute state of recurrent ulcer activation of the microflora displaying pathogenetic signs and corresponding to the third or fourth degree of dysbacteriosis takes place in the ulcerous defect zone along with microcirculatory disorders, necrotic inflammatory processes and reduction of the lysozyme content in tissues. This allows comparing ulcers of the gastroduodenal zone to an infected wound. At the sub-acute phase of recurrent ulcer (next one or two weeks) microbiological changes in the per-ulcer zone reduce to dysbacteriosis of the second or third degree as inflammatory and necrotic processes cease, an at the phase of cicatrisation and epithelization they are similar to normal biocenosis.

Topics: Acute Disease; Adult; Bacteria; Duodenal Ulcer; Female; Humans; Intestinal Mucosa; Male; Microcirculation; Middle Aged; Muramidase; Peptic Ulcer; Recurrence; Stomach Ulcer; Time Factors; Wound Infection

To investigate aggressive-protective factors in patients with erosive lesions of gastroduodenal mucosa.. Intragastric pH-metry, tests for Helicobacter pylori, lysozyme activity, content of bile acid in gastric juice, components of gastric mucous gel were made in 106 patients.. It is shown that there are two alternative paths of erosions development in the gastroduodenal zone: infectious and non-infectious.. In patients infected with Helicobacter pylori, lowering of a protective ability of the mucous gel is caused by prevalence of synthesis of immature mucous components while in non-infected patients this happens as a result of high catabolism of mucous components.

Topics: Adult; Bile Acids and Salts; Duodenal Ulcer; Duodenitis; Gastric Juice; Gastric Mucosa; Gastritis; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Middle Aged; Mucus; Muramidase; Peptic Ulcer; Stomach Ulcer

Pathogenesis substantiation and clinical efficiency of transendoscopic treatment of the patients with gastroduodenal ulcers relapse by lysozyme compound with molecular iodine and polyiodides are presented in this paper. The relapse of peptic ulcer was accompanied by lysozyme decrease and helicobacter's sowing increase in stomach and duodenal mucosa, as well as activity mucosa flora increase, especially in periulcer's region. This fact has drown near ulcer's defect and infected wound. Significant microbicidal and sorptional effects to the revealed strains of microorganisms, mucous membrane barrier properties increase and shortening of the peptic ulcer's scarring time on 8 days were demonstrated after transendoscopic treatment of the peptic ulcer with iodine lysozyme 3-4 times.

Topics: Anti-Infective Agents, Local; Bacterial Infections; Combined Modality Therapy; Endoscopy; Gastric Mucosa; Humans; Iodides; Muramidase; Peptic Ulcer; Secondary Prevention

Indices of unspecific resistance (bactericidal serum activity, phagocytic reaction of neutrophils, lysozyme) were examined in 128 patients with ulcer disease and chronic gastritis. Changes of local and general mechanisms of unspecific reactivity of the gastro-intestinal tract result not only in disorders of the defence system but also in a reduction of viability of the gastric and duodenal epithelium with development of alteration processes. In this condition bacterial and protein antigens may change the immunological status of the body.

Topics: Blood Bactericidal Activity; Chronic Disease; Gastric Juice; Gastritis; Humans; Immunity, Innate; Muramidase; Peptic Ulcer; Phagocytosis

Systemic and local humoral immunity and nonspecific defense factors were investigated in 88 patients with duodenal peptic ulcers and 18 patients with gastric ulcers. In acute conditions, nonspecific defence was depressed and blood IgG level was increased in peptic ulcer patients. An increase in complement titre, C3 and lysozyme, and a decrease in IgG were recorded after treatment, although normal levels were never attained. Salivary, gastric-juice and duodenal-content secretory IgA levels were characteristically increased during acute phases of peptic ulcer; salivary IgA declined after treatment. The disturbance of nonspecific defence, systemic and local humoral immunity, demonstrated in patients with peptic ulcers, may be regarded as a possible ulcerogenic mechanism.

Topics: Acute Disease; Adolescent; Adult; Antibody Formation; Complement C3; Female; Gastric Juice; Humans; Immunoglobulins; Male; Middle Aged; Muramidase; Peptic Ulcer; Saliva

The authors provide the data concerning changes in humoral and cellular immunity as well as factors of nonspecific defense under the effect of a new treatment method for frequently relapsing peptic ulcer. The method is based on administering a granulocyte concentrate by ulcer pricking around. It was noted that in peptic ulcer patients, humoral and cellular immunity returned to normal as did the factors of nonspecific defense.

Topics: Adult; Complement System Proteins; Humans; Immunity, Cellular; Immunoglobulins; Immunotherapy; Middle Aged; Muramidase; Neutrophils; Peptic Ulcer; Phagocytosis; Recurrence; Rosette Formation

The investigations have shown that the routine preoperative preparation fails to exert a marked positive influence on the parameters of nonspecific resistance of the organism. The employment of the original authors' system of preoperative preparation in patients with ulcer disease results in the elevation of natural resistance of the organism, better endurance to operation.

Topics: Adult; Aged; Complement System Proteins; Female; Humans; Immunity, Innate; Male; Middle Aged; Muramidase; Peptic Ulcer; Postoperative Period; Preoperative Care; Time Factors

Topics: Acute Disease; Child; Gastric Juice; Histamine; Histamine Antagonists; Humans; Hypersensitivity, Immediate; Muramidase; Peptic Ulcer

The activity of lysozyme in the saliva, blood serum and gastric juice was studied in 51 patients operated upon for peptic ulcers. The activity of lysozyme in the acid gastric juice was found to be lower than that in the neutral and low-alkaline medium. Following vagotomy, the contents of lysozyme in the blood serum and gastric juice was higher than following the resection of the stomach. The investigation of factors of non-specific defense of the organism, lysozyme in particular, is thought to be necessary for the estimation of the postoperative period and healing of the ulcer.

Topics: Adult; Aged; Antibody Formation; Female; Gastrectomy; Gastric Acidity Determination; Gastric Juice; Humans; Immunity, Innate; Male; Middle Aged; Muramidase; Peptic Ulcer; Saliva; Vagotomy

The state of phagocytic activity of neutrophils, phagocytic index, opsonic coefficient, activity of blood serum lysozyme were studied with acute gastro-intestinal hemorrhages (ulcerous etiology in 116 patients, non-ulcerous etiology in 76 patients). The dependence of reduction of indices of phagocytosis and blood serum lysozyme on the degree of blood loss and duration of the posthemorrhagic period was revealed which may be used in clinical practice.

Topics: Acute Disease; Adolescent; Adult; Aged; Blood Volume; Female; Gastrointestinal Hemorrhage; Humans; Immunity, Innate; Male; Middle Aged; Muramidase; Peptic Ulcer; Peptic Ulcer Hemorrhage; Phagocytosis; Recurrence

Lysozyme concentration in the gastric juice of 34 patients with peptic ulcer and 10 practically healthy persons was studied. In the patients with peptic ulcer the lysozyme levels in the gastric juice were found to be lower. A significant decrease in the lysozyme concentration was observed in the patients suffering from peptic ulcer for more than 2 years. During the first months of the disease increased levels of lysozyme were recorded. Relationship between the lysozyme concentration in the gastric juice and the acidity of the gastric contents was shown. Decreased concentrations of lysozyme were more pronounced in the patients with increased levels of hydrochloric acid.

Topics: Adolescent; Adult; Duodenal Ulcer; Enzyme Activation; Fasting; Female; Gastric Acidity Determination; Gastric Juice; Humans; Male; Middle Aged; Muramidase; Peptic Ulcer; Stomach Ulcer; Time Factors

Topics: Adult; C-Reactive Protein; Complement System Proteins; Humans; Immunity, Innate; Middle Aged; Muramidase; Peptic Ulcer; Postoperative Complications; Properdin; Stomach Neoplasms; Surgical Wound Infection

Topics: Chronic Disease; Gastric Mucosa; Gastritis; Humans; Muramidase; Peptic Ulcer

Topics: Adult; Chronic Disease; Female; Gastrectomy; Gastric Juice; Humans; Male; Middle Aged; Muramidase; Peptic Ulcer; Saliva

Topics: Blood Transfusion, Autologous; Complement System Proteins; Gastrectomy; Humans; Muramidase; Peptic Ulcer; Phagocytosis

Topics: Colitis; Colitis, Ulcerative; Gastrointestinal Diseases; Humans; Muramidase; Peptic Ulcer

Topics: Anti-Infective Agents, Local; Histamine; Humans; Mucous Membrane; Mucus; Muramidase; Peptic Ulcer; Ulcer

Topics: Anions; Antacids; Anti-Infective Agents, Local; Glycoside Hydrolases; Muramidase; Peptic Ulcer; Polymers

Topics: Antiviral Agents; Digestion; Gastric Juice; Humans; Muramidase; Peptic Ulcer

Topics: Anti-Infective Agents, Local; Antiviral Agents; Dermatologic Agents; Humans; Muramidase; Peptic Ulcer; Proteins; Ulcer

Topics: Colitis; Colitis, Ulcerative; Food; Humans; Muramidase; Peptic Ulcer; Proteins; Ulcer

Topics: Humans; Muramidase; Peptic Ulcer