muramidase and Osteomyelitis

The article demonstrates that the examination of patients with chronic osteomyelitis treated using the transosseous osteosynthesis technique established the ambiguous character of changes in concentration of lactoferrin and lysozyme in blood serum as compared with pre-surgery values. It is demonstrated that closer to the end of 2-3 months after surgery the normalization of analyzed indicators occurs. The complex detection of lactoferrin, lysozyme applied additionally to basal examination of cell immunity can be used to monitor the chronic osteomyelitis. This approach can play a significant diagnostic and prognostic role in evaluation of severity on infection process.

Topics: Adult; Aged; Chronic Disease; Female; Humans; Lactoferrin; Male; Middle Aged; Muramidase; Osteomyelitis

Anti-infectious resistance factors and microflora in the focus of inflammation have been studied over the course of chronic posttraumatic osteomyelitis in adults. This disease is associated with elevated levels of leukocytes, lymphocytes, IgG, normal or elevated levels of IgA and lysozyme in the peripheral blood. The data obtained in the immunological examination of chronic osteomyelitis patients indicate that such patients fall into two groups: with and without pronounced IgM deficiency. Changes in microbiological and immunological characteristics vary in different groups. A detailed characterization of microflora in the focus of inflammation over the course of the disease in all patients and in individual groups of patients is presented, and the dynamics of anti-infectious resistance factors is shown to reflect changes in microflora in the focus of lesion, which is manifested by changes in immunoglobulin levels corresponding to primary (the initial IgM level being normal) and secondary (a low IgM level) immune response.

Topics: Adult; B-Lymphocytes; Bacteria; Chronic Disease; Complement System Proteins; Humans; Immunity, Innate; Immunoglobulins; Leukocyte Count; Muramidase; Osteomyelitis; Rosette Formation; T-Lymphocytes; Wounds and Injuries

Topics: Antitoxins; Complement System Proteins; Humans; Jaw Diseases; Muramidase; Osteomyelitis; Staphylococcal Infections

Topics: Age Factors; Blood Bactericidal Activity; Humans; Immunity; Immunologic Techniques; Infant; Infant, Newborn; Lysine; Muramidase; Osteomyelitis; Phagocytosis; Pneumonia, Staphylococcal; Staphylococcal Infections; Staphylococcal Toxoid

Topics: Adult; Bone Marrow; Butanols; Creatinine; Freezing; Humans; Leukocyte Count; Meningitis; Methods; Muramidase; Myeloproliferative Disorders; Neutrophils; Osteomyelitis; Pneumonia; Staphylococcal Infections; Ultrasonics; Uremia

Topics: Acute Disease; Cellulitis; Chronic Disease; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Lymphadenitis; Muramidase; Osteomyelitis; Pneumonia, Staphylococcal; Staphylococcal Infections

Topics: Abscess; Adolescent; Adult; Antitoxins; Blood Bactericidal Activity; Cellulitis; Complement System Proteins; Humans; Middle Aged; Muramidase; Osteomyelitis; Otitis; Phagocytosis; Sinusitis; Staphylococcal Infections; Surgical Wound Infection; Tonsillitis; Ulcer