muramidase has been researched along with Leukemia-P388* in 2 studies
2 other study(ies) available for muramidase and Leukemia-P388
| Article | Year |
|---|---|
Activation of P388D1 macrophage cell line by chemotherapeutic drugs.
It has been found that certain antineoplastic drugs impart their function with a distinct duality. Besides being tumoricidal, they are capable of acting as immunopotentiator. This led us to investigate the effect of cytosine arabinoside (CA), vincristine sulphate (VS), cyclophosphamide (CS), mitomycin C (MMC), hydroxy urea (HU) and lipopolysaccharide (LPS) on a macrophage cell line P388D1. Supernatants collected from P388D1 cells treated with CA, VS, CS, MMC, HU or LPS demonstrated enhanced production of tumor necrosis factor (TNF) confirmed by bioassay on L929 tumor target cells and increased interleukin-1 (IL-1) production by standard thymocyte proliferation bioassay. Also, supernatants showed increased amounts of nitric oxide and lysozyme using Griess reaction and reduction in turbidity of Micrococcus lysodeikticus, respectively. The above findings demonstrate that these drugs may be used not only as chemotherapeutic agents but also as macrophage-activating agents. Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Hydroxyurea; Interleukin-1; Leukemia P388; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred DBA; Muramidase; Nitric Oxide; Tumor Necrosis Factor-alpha | 1997 |
Inhibition of some spontaneous secretory processes in macrophages and fibroblasts by ammonium chloride.
Ammonium chloride inhibits the spontaneous secretion of lysozyme by mouse macrophages and the murine macrophage-like cell line P388D1 and the spontaneous secretion of lysosomal enzymes by P388D1 cells, normal human fibroblasts and the hypersecretory mucolipidosis II (I-cell) fibroblasts. NH4Cl can also inhibit protein synthesis, but this is shown to occur mainly at higher concentrations, or after longer periods of exposure, than are needed for the inhibition of the spontaneous secretory processes. It is confirmed that this amine can also interfere with the continuous endocytosis of fluid in the murine cell types. The nature of the inhibitions is discussed. Topics: Ammonium Chloride; Animals; Cells, Cultured; Cycloheximide; Fibroblasts; Humans; Kinetics; Leukemia P388; Leukemia, Experimental; Lysosomes; Macrophages; Mice; Mucolipidoses; Muramidase; Protein Biosynthesis; Skin | 1983 |