muramidase and Leukemia--Lymphoid

Topics: Anemia, Aplastic; Animals; Bacteriological Techniques; Bone Marrow; Glomerular Filtration Rate; Histological Techniques; Humans; Hypersplenism; Immunologic Techniques; Iodine Radioisotopes; Kidney; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Muramidase; Neutrophils; Phosphorus Radioisotopes; Polycythemia Vera; Rabbits

Topics: Acute Disease; Aged; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Middle Aged; Muramidase; Remission, Spontaneous

Topics: Amyloidosis; Blood Protein Disorders; Bone Neoplasms; gamma-Globulins; Humans; Karyotyping; Kidney Diseases; Kinetics; Leukemia; Leukemia, Lymphoid; Leukemia, Plasma Cell; Lung Neoplasms; Lymph Nodes; Lymphoma; Microscopy, Electron; Multiple Myeloma; Muramidase; Plasmacytoma

Topics: Acute Kidney Injury; Animals; Body Fluids; Cell Wall; Clinical Enzyme Tests; Humans; Hydrolysis; Immunodiffusion; Kidney Diseases; Kidney Tubules; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Micrococcus; Molecular Weight; Muramidase; Rats; Spectrophotometry

Serum lysozyme activity was measured in samples from 65 children with acute lymphatic and myelogenous leukemia, solid tumors and malignant lymphoma in comparison with 45 healthy children. All children with acute lymphatic leukemia (ALL) had significantly reduced levels of lysozyme before starting therapy compared with a control group (p less than 0,01). Children with ALL in complete remission had lysozyme levels comparable to normal children, while children with ALL in relapse showed pathological low levels again. Children with acute myelogenous leukemia (AML), solid tumors and malignant lymphomas had higher lysozyme concentration before therapy than healthy children. Determination of lysozyme activity in children with acute leukemia and malignant tumors is of value for diagnosis and to control the effect of therapy.

Topics: Child; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Muramidase; Neoplasms

Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Humans; Immunoglobulins; Leukemia, Lymphoid; Leukocyte Count; Leukocytes; Middle Aged; Muramidase

The paper discusses the data on secretion of immunoglobulin and lysozyme in the upper respiratory tract of patients with acute leukemia. The data were used in the evaluation of certain biological preparations intended for prevention of infectious complications.

Topics: Bacterial Infections; Bacteriophages; Humans; Immunoglobulin A, Secretory; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mucous Membrane; Muramidase; Pharynx; Pseudomonas aeruginosa; Staphylococcus Phages

Plasma and intracellular levels of lactate dehydrogenase (LDH), phosphohexose isomerase (PHI) and lysozyme activities were investigated in 20 patients with acute myelocytic leukemia (AML), 18 patients with acute lymphatic leukemia (ALL) and 10 patients with chronic myelocytic leukemia in blast transformation (CML/BT). Though the plasma levels of LDH and PHI in all patients with acute leukemia were elevated as compared to control persons there was no distinctive pattern which could be of use in the classification of acute leukemia. On the other hand the intracellular levels of these enzymes could be of value in classifying acute leukemia. The leukemic lymphoblasts were characterized by low levels of PHI and lysozyme as compared to leukemic myeloblasts or to normal lymphocytes (p less than 0.01). The LDH/PHI ratio is also significantly higher in leukemic lymphoblasts than in leukemic myeloblasts or in normal lymphocytes (p always less than 0.01). These characteristics might also be made use of in identifying the blasts of CML/BT als "lymphoid" or "myeloid" in corresponding cases.

Topics: Acute Disease; Adolescent; Adult; Aged; Child; Female; Glucose-6-Phosphate Isomerase; Humans; L-Lactate Dehydrogenase; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Middle Aged; Muramidase; Neoplasm Proteins; Neoplastic Stem Cells; Stem Cells

Topics: Adolescent; Adult; Humans; Immunity, Innate; Leukemia, Lymphoid; Leukemia, Myeloid; Middle Aged; Muramidase; Neutrophils; Phagocytosis

Using FAB criteria, we retrospectively classified 195 adult acute leukemia cases seen over a six-year period. Acute lymphoblastic leukemia (ALL) was separated from acute nonlymphoblastic leukemia (ANLL) by negative peroxidase. The dysmyelopoietic syndrome was separated from ANLL when the percentage of immature leukemic cells was less than 30%. The 55 cases of ALL and 140 cases of ANLL thus defined were initially independently subclassified with Wright's stained smears by three observers. Cases were then jointly reviewed by using all available information, and a final consensus diagnosis was reached. For ALL, there was complete agreement (of initial independent observations) about subtype in 32 of 55 (58%); for only one case was there total disagreement. For ANLL there was complete agreement in 89 of 140 (64%) and total disagreement in 5 of 140 (4%). Frequent disagreement of independent observations with the consensus diagnosis were L1 interpreted as 12, M5 interpreted as M4, L3 interpreted as L2, L2 interpreted as L1, M1 interpreted as M2 and M4 interpreted as M5. Although there appears to be variation between observers, all but 6 of 195 cases had at least two observers in agreement. Disagreement appeared to be partly based on varying interpretations of subjective criteria and partly on the variability in determining percentages of cell types present. The use of nonspecific esterase stain or lysozyme appeared to improve diagnostic agreement over that observed using Wright's stained slides alone in approximately 5% of cases of ANLL.

Topics: Esterases; Humans; Leukemia; Leukemia, Lymphoid; Muramidase; Peroxidases; Retrospective Studies; Staining and Labeling

Topics: Acid Phosphatase; Adult; Cell Differentiation; DNA Nucleotidylexotransferase; Esterases; Granulocytes; Histocytochemistry; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Monocytes; Muramidase; Peroxidase

Studies have been made on lysozyme in serum and tissue homogenates in normal and leukaemic mice. An increase in serum lysozyme level occurred in mice bearing both strains of leukaemia as compared to the normal counterparts. Moreover, the elevated enzyme levels seem to be related to the rise in neutrophils in peripheral blood. In the spleen and kidney of leukaemic mice, the lysozyme level was found to be lower than in the normals, while the enzyme level remained more or less unaltered in the liver. The findings are discussed in relation to other reports in the literature.

Topics: Animals; Female; Leukemia Virus, Murine; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Lymphocytes; Male; Mice; Mice, Inbred Strains; Moloney murine leukemia virus; Muramidase; Neutrophils; Spleen; Tumor Virus Infections

Topics: Child; Child, Preschool; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Muramidase

Topics: Biological Products; Feces; Humans; Immunoglobulins; Intestinal Diseases; Intestines; Leukemia, Lymphoid; Muramidase

Topics: Humans; Leukemia; Leukemia, Hairy Cell; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Muramidase

Topics: Enzyme Activation; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocytes; Muramidase; Phagocytosis

Enzymatically homogeneous populations of lymphocytes, monocytes, and neutrophils were isolated by zonal centrifugation from 5 untreated patients with chronic lymphocytic leukemia (CLL) and 2 patients with CLL in full remission. The cells were then quantitatively analyzed for six leukocytic enzymes and compared with cells from normal subjects. CLL monocytes were deficient in beta-glucuronidase (0.06 units; normal, 0.16), myeloperoxidase (0.07 mg; normal, 0.5 mg), and lysozyme (0.7 mg; normal, 3.3 mg). In 2 cases, CLL neutrophils were severely deficient in lysozyme (1 to 2 mg; normal, 7 mg) and myeloperoxidase (2 to 3 mg; normal, 7 mg). Neutrophil alkaline phosphatase and neutral protease were unaffected. CLL lymphocytes shared with the monocytes the deficiency of beta-glucuronidase (0.03 units; normal, 0.09 units). The 2 CLL patients in full remission carried normal enzyme levels in leukocytes of all three cell lines. The CLL lymphocytes of untreated patients were unresponsive to mitogens but became responsive in remission. The CLL monocytes from both untreated and treated patients transformed into macrophages. The pattern of shared enzyme deficiency among lymphocytes, monocytes, and neutrophils of CLL patients and its normalization in all three cell types under remission suggest that the differentiation of the three leukocytic cell lines may be an enzymatically interlinked process and that the deficiency of these enzymes in leukemia may reflect an interrelated aberrant differentiation of the leukemic cells.

Topics: Acid Phosphatase; Cell Separation; Centrifugation, Density Gradient; Glucuronidase; Granulocytes; Humans; Leukemia, Lymphoid; Monocytes; Muramidase; Peroxidase

Topics: Child; Complement C1 Inactivator Proteins; Complement C3; Complement C4; Humans; Leukemia, Lymphoid; Muramidase

The diagnostic and prognostic value of the assay of lysozyme in serum and urine was appreciated in 184 cases of acute leukemia. The levels were decreased in the lymphoblastic, mainly of the non B-non T type, and undifferenciated varieties, markedly raised in the monoblastic and myelo-monocytic varieties, while in the myeloblastic ones they were found normal, decreased or slightly increased, and, on the average, significantly higher in the well differenciated than in the poorly differenciated types. For a given cytological type, the level of lysozyme is not correlated with the frequency of the induction of complete remission. However, in the acute myeloblastic leukemia, a significantly higher frequency of infection during or after the induction treatment was observed in the cases presenting initially without a raised serum lysozyme level.

Topics: Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Muramidase; Prognosis

Serum lysozyme activity was measured in samples from adult patients with acute leukemia, malignant tumors, and in normal adults. Twenty-eight adult patients with acute myelogenous leukemia (AML) had significantly elevated levels of lysozyme at diagnosis, and none of the adults fell within the normal range. Thirty-two patients with AML in complete remission had lysozyme levels comparable to normal adults, whereas patients with AML in relapse (eight cases) also had abnormally high levels of lysozyme activity. Ten patients with AML in remission and off therapy also had normal lysozyme levels. Three patients with acute lymphatic leukemia had normal lysozyme levels, while one child with monomyelocytic leukemia had substantially elevated lysozyme levels before treatment. It seems that in patients in remission and with normal blood values, the serum lysozyme activity is valuable for monitoring the remission.

Topics: Adult; Antineoplastic Agents; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Non-Hodgkin; Muramidase; Prognosis; Remission, Spontaneous

In a consecutive series of 22 patients with acute leukemia, the total body potassium was studied in 18 patients on 39 occasions during relapse and remission. Total body water was also determined. A control group consisting of 88 age-matched healthy volunteers was also studied. The patients had a significantly lower mean potassium concentration, per kg body weight, per kg lean body mass and per kg water, than the controls (p less than 0.001). Individually, 11 out of the 18 patients had at least one value below the lower 95% confidence limit. Hypokalemia was frequent both in the patients with low (7/11) and normal (3/6) potassium per kg lean body mass. Five of 13 investigated patients showed laboratory indications of secondary hyperaldosteronism, which might be partly responsible for the hypokalemia. Increased serum or urine levels of lysozyme were found in 62% of the patients.

Topics: Adult; Aged; Aldosterone; Antineoplastic Agents; Electrolytes; Female; Humans; Hypokalemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Middle Aged; Muramidase; Potassium; Renin

Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Leukemia, Lymphoid; Muramidase

Serum lysozyme activity was measured in samples from children with acute leukemia, malignant tumours, and in normal children. All children with acute lymphatic leukemia (ALL) had significantly reduced levels of lysozyme at diagnosis, and none of the children fell within the normal range. Children with ALL in complete remission had lysozyme levels comparable to normal chidren, while children with ALL in relapse also had pathological low levels. Children with ALL in remission and off therapy also had normal levels of lysozyme. Children with acute myelogenous leukemia had normal lysozyme levels, while children with monomyelocytic leukemia had substantially elevated lysozyme levels before treatment. Determination of serum lysozyme activity in children with acute leukemia is of value both for diagnosis and for evaluating the effect of therapy.

Topics: Acute Disease; Child; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Muramidase; Remission, Spontaneous

Topics: Hematologic Diseases; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma; Muramidase; Myeloproliferative Disorders

Topics: Acid Phosphatase; Histocytochemistry; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Muramidase; Naphthol AS D Esterase; Peroxidases

The authors report the data on immunoglobulins G, A, M content and their relationship with other factors of natural immunity in 55 patients with acute myeloblastic leukemia and in 43 patients with chronic lymphatic leukemia. The results have evidenced the impaired synthesis of immunoglobulins in acute in acute leukemia and the reduction of IgA and IgM already in the initial stage of chronic lymphatic leukemia. A correlation between mean values of immunoglobulins content and other factors of immunological resistance allowed a statement to be made that in the absence of impaired immunoglobulins synthesis there is a distinct coincidence of immunoglobulin content curves and titres of agglutinating and bacteriolytic antibodies.

Topics: Agglutination Tests; Antibodies, Bacterial; Bacteriolysis; Humans; Immunity, Innate; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Muramidase; Phagocytosis; Salmonella typhimurium; Staphylococcus

The amount of lysozyme in the leukocytes of 47 patients with different forms of leukaemia and 6 healthy persons was investigated. The lysozyme determination was carried out in the lysate of isolated leukocytes obtained after freezing and thawing it seven times. The results expressed in microgram per 10(6) cells were compared with the simultaneously determined lysozyme concentration of serum and urine. A substantial reduction of the lysozyme amount as compared with the normal value (3.1 microgram/10(6) cells) was determined in the leukocytes of patients suffering from chronic lymphatic leukaemia, acute lymphatic leukaemia and the blastic crisis of chronic myeloid leukaemia. Different amounts of lysozyme ranging from extremely low ones to strongly elevated ones were found in leukocytes taken from patients with acute myeloblastic and chronic monocytic leukaemia. In many cases there was a lack of correlation between the lysozyme content of leukocytes on the one hand and that of serum and urine on the other hand. Possible causes underlying this lack of correlation are discussed.

Topics: Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Muramidase

The levels of haptoglobin, alpha1 antitrypsin and alpha1 acid glycoprotein are moderately raised in chronic leukaemias. In CGL the level of haptoglobin and acid glycoprotein show the highest correlation with cell number, whilst no such correlations occur in CLL or CMML. There does not appear to be a relation between blood lysozyme levels and the levels of antiprotease (alpha1 antitrypsin and alpha2 macroglobulin).

Topics: alpha 1-Antitrypsin; alpha-Macroglobulins; Chronic Disease; Haptoglobins; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Muramidase; Orosomucoid

Topics: Granulocytes; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Monocytes; Muramidase

A simple cytochemical and cytobacterial method for the simultaneous demonstration of peroxidase and lysozyme (muramidase) activities in individual cells was devised. In characterization of myeloid and monocyte series, the combination of these myeloid- and monocyte-specific enzymes not only was more informative than a single enzyme but made it easier to differentiate acute myelomonocytic leukemia, with higher lysozyme activity, from acute myeloid leukemia, with higher peroxidase activity. Acute lymphocytic leukemia had no lysozyme or peroxidase activity.

Topics: Bone Marrow; Bone Marrow Cells; Histocytochemistry; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Muramidase; Peroxidases

In sera of patients with acute leucosis the authors have determined antibodies to alpha-toxin, streptolysin-O, the complement, lysosyme. B-lysins and C-reactive protein. It was found that the indices of immune reactivity in patients with acute leucosis are dependent on a morphological variant of the disease, the duration of the conducted therapy and presence of complications. The most high immunity indices in patients with acute leucosis were observed in a primary active stage of the disease and during the period of remission. Considerable reduction of the immunity was noted in the terminal stage of the disease.

Topics: Adult; Aged; Amino Acid Isomerases; Antistreptolysin; Antitoxins; C-Reactive Protein; Complement System Proteins; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Middle Aged; Muramidase

Topics: Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Muramidase

Serum lysozyme activity has been determined in patients suffering from myeloproliferative diseases, chronic myelogenous leukaemia (CML), acute myelogenous leukaemia (AML), chronic lymphatic leukaemia (CLL) and pancytopenia (P). Lysozyme activity was tested in undiluted and tenfold diluted sera. Increased lysozyme activity was found in patients with CML and CLI, whereas there was no change in patients with AML and P. Dilution of sera enhanced lysozyme activity. These data may indicate the presence of inhibitor in the sera tested. The diagnostic significance of the presented findings is discussed.

Topics: Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Muramidase; Myeloproliferative Disorders; Pancytopenia

A 68-year-old woman presented with haematological changes of chronic lymphocytic leukaemia and acute monocytic leukaemia. This diagnosis was confirmed by identification of cell surface markers for T and B lymphocytes and the identification of abnormal immunoglobulins and lysozyme in serum and urine.

Topics: Aged; Antigens; B-Lymphocytes; Female; Humans; Immunoglobulins; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Muramidase; Neoplasms, Multiple Primary; T-Lymphocytes

Lysozyme activity was studied in blood smears, serum, and urine of patients suffering from leukaemia or other haematological diseases. Increased enzyme activity was found in myelocytic, myelomonocytic and monocytic leukaemia and equally in secondary granulocytosis and polycythaemia vera. Reduced rates were found in lymphocytie leukaemia, malignant lymphoma with bone marrow involvement, and myelophthisic conditions. A rise in urinary lysozyme occurred when the serum level exceeded 50 microgram/ml. Abundant activities were found in myelomonocytic and monocytic leukaemias. Using the bacteriolytic method in blood smears, no enzyme activity was demonstrated in cells of acute or chronic lymphocytic leukaemia, in monocytic leukaemia however, almost all cells show strong reaction. In acute myelocytic or myelomonocytic leukaemia, the portion of positive cells changes from case to case depending on the degree of cell differentiation and maturation. In chronic myelocytic leukaemia there was no difference as compared to enzyme activity of myelocytes in bone marrow of control cases. Thus the bacteriolytic demonstration of lysozyme in blood smears may additionally contribute to distinction of different types of blastic leukaemias, and serum lysozyme also may allow more reliable insight into granulocytic and monocytic myelopoiesis than morphologic studies of blood or bone marrow smears can do, e.g. in agranulocytosis and pancytopenia.

Topics: Anemia, Aplastic; Hematologic Diseases; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Muramidase; Waldenstrom Macroglobulinemia

Topics: Adult; Aged; Antibody Formation; Female; Humans; Immunoglobulins; Leukemia, Lymphoid; Male; Middle Aged; Muramidase

Topics: Adult; Age Factors; Allopurinol; Antineoplastic Agents; Cerebral Hemorrhage; Child; Emergencies; Humans; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Muramidase; Prednisone

On a model of experimental pneumonia in mice caused by the L-forms of bacteria against the background of diminished immunity a study was made of the therapeutic efficacy of penicillin, lincomycin, lysozyme and gamma-globulin. Lincomycin, particularly in combination with biologically-active preparations, proved to be expedience for the treatment and prophylaxis of pneumonia caused by the mentioned bacteria; a rapid arrest of pneumonic process occurred and more animals survived. In the greater percentage of cases the use of penicillin was accompanied by generalization of the process.

Topics: Animals; gamma-Globulins; Humans; Immunosuppression Therapy; Immunosuppressive Agents; L Forms; Leukemia, Lymphoid; Lincomycin; Mercaptopurine; Mice; Muramidase; Penicillins; Pneumonia

Nineteen children aged from 3 to 16 years with first long-term hematologic remission were studied. Cell-mediated immunity was assayed by the reaction to dinitrochlorobenzene (DNCB), nitroblue tetrazolium reduction test (NBT) and lysozyme activity. Humoral immunity was determined by immunoglobulin (IgG, IgA, IgM) levels in serum. The DNCB-reaction was positive in 50% of children treated from 12 to 36 months. Percentage and absolute counts of NBT-positive granulocytes and lysozyme/granulocyte ratio systematically increased with time of therapy. In all studied children IgG was normal, IgA and IgM were depressed to 40% and 76% of normal value (with the exception of 2 children after cessation of therapy, in which IgA was normal). It seemed that continuous control of the immunologic status during long-term cytostatic therapy is essential in clinical practice.

Topics: Adolescent; Adult; Child; Child, Preschool; Dinitrochlorobenzene; Humans; Hypersensitivity; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Leukemia, Lymphoid; Muramidase; Nitroblue Tetrazolium; Remission, Spontaneous

The kidneys of 18 autopsy cases of myelomonocytic leukemia (MML) were examined for MML-specific features. Nine cases of chronic lymphocytic leukemia (CLL) served as controls. The kidneys of the cases of MML showed macroscopically detectable signs of hemorrhagic diathesis and secondary uric acid diathesis more often than those of CLL. In the MML group most of the kidneys weighed more than the normal average for the corresponding age group, but the average renal weights for the 2 groups were about the same. Renal weight and grade of leukemic infiltration, particularly in MML, revealed no significant positive correlation. In most of the cases of MML there were unevenly distributed poorly defined leukemic, infiltrates in the renal cortex and medulla. The histology resembled that of pyelonephritis. In CLL, on the other hand, the leukemic infiltrates were usually sharply defined and localized in foci in the outer cortex and the corticomedullary border region. Renal dysfunction in cases of MML has been attributed by others to hyperlysozymemia. It was found occasionally but there was no MML-typical morphological substrate in our material. Hyaline droplet change of the tubular epithelium was more frequent and more pronounced in MML than in CLL. However, we also determined that it was nonspecific and that it was not a parameter of cell damage. Tubular hyaline droplet change and the morphological criteria of acute renal failure were not positively correlated with the degree of leukemic infiltration of the kidneys or with the leukemic proliferation as a whole. Instead, they were considered to be signs and symptoms of accompanying or secondary diseases which complicated the leukemia.

Topics: Acute Kidney Injury; Adult; Aged; Edema; Female; Humans; Kidney; Kidney Glomerulus; Kidney Tubules; Leukemia, Lymphoid; Leukemia, Myeloid; Liver; Male; Middle Aged; Muramidase; Nephrocalcinosis; Organ Size; Pyelonephritis; Spleen; Uric Acid

Pretreatment serum lysozyme activity was high in 2 children with myelomonocytic leukemia, 800 and 1 000 mug/ml, normal in all 10 cases of acute lyelocytic leukemia and subnormal in 21 of 34 cases of acute lymphocytic leukemia. Normal values were found in all but one case of acute lymphocytic leukemia during complete remission including 8 cases after all therapy had been discontinued. All 8 are still in complete remission. Low serum lysozyme activity was found in 5 patients with acute lymphocytic leukemia in complete relapse, this could possibly be helpful in the diagnosis of early relapse. Activity was subnormal in 5 of 17 children with malignant tumours, and in 3 of 65 cases of various benign hematological disorders.

Topics: Child; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Muramidase

Topics: Animals; Histocytochemistry; Immune Sera; Kidney; Kidney Tubules; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocytes; Mice; Mice, Inbred AKR; Microscopy, Electron; Muramidase; Neoplasm Transplantation; Peroxidases; Rabbits; Time Factors; Transplantation, Homologous

Topics: Adult; Cell Separation; Hematopoietic Stem Cells; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Muramidase; Neutrophils; Recurrence

Topics: Acid Phosphatase; Animals; Animals, Newborn; Cat-Scratch Disease; Glucuronidase; Hexosaminidases; Humans; Infectious Mononucleosis; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocytes; Muramidase; Rats; Waldenstrom Macroglobulinemia

Topics: Adult; Female; Hematologic Diseases; Humans; L-Lactate Dehydrogenase; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocyte Count; Lymphocyte Activation; Male; Muramidase; Remission, Spontaneous; Uric Acid

Topics: Adult; Anemia; Anemia, Sideroblastic; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemoid Reaction; Leukocytosis; Monocytes; Muramidase; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis

Topics: Adolescent; Adult; Aged; Diagnosis, Differential; Esterases; Histocytochemistry; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocytes; Lymphocytes; Middle Aged; Muramidase; Prognosis

Topics: Acute Disease; Adenosine; Aminohydrolases; Electrophoresis; Humans; Isoenzymes; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocytes; Muramidase; Mycosis Fungoides; Phenotype

Topics: Adult; Aged; Blood Cell Count; Bone Marrow Cells; Bone Marrow Examination; Child; Cytarabine; Densitometry; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Middle Aged; Muramidase; Remission, Spontaneous; Thioguanine; Vincristine

Topics: Adult; Electrophoresis; Glomerular Filtration Rate; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Muramidase; Polycythemia; Polycythemia Vera

Topics: Acid Phosphatase; Alkaline Phosphatase; Cell Fractionation; Centrifugation, Density Gradient; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Monocytes; Muramidase; Neutrophils; Phagocytosis

Topics: Clinical Enzyme Tests; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Muramidase

Topics: Clinical Enzyme Tests; Diagnosis, Differential; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Muramidase

Topics: Egg White; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Mass Screening; Muramidase; Pyelonephritis; Sarcoidosis; Tears; Tuberculosis

Topics: Adolescent; Adult; Aged; Agranulocytosis; Allopurinol; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Blood Transfusion; Cytarabine; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Middle Aged; Muramidase; Nausea; Prednisolone; Thrombocytopenia; Vincristine

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Lymphoma; Male; Middle Aged; Multiple Myeloma; Muramidase; Sarcoidosis; Seasons

Topics: Bone Marrow Cells; Clinical Enzyme Tests; Diagnosis, Differential; Histocytochemistry; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Muramidase

Topics: Adult; Bone Marrow Examination; Densitometry; Female; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Methods; Muramidase; Spectrophotometry

Topics: Acetates; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Glucose; Glutamates; Glycogen; Glycolysis; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Lipids; Muramidase; Pentoses

Topics: Bone Marrow; Bone Marrow Cells; Diagnosis, Differential; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Muramidase

Topics: Adult; Anemia, Aplastic; Child; Hematologic Diseases; Hodgkin Disease; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemoid Reaction; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma; Muramidase; Mycosis Fungoides; Myeloproliferative Disorders; Polycythemia Vera

Topics: Adolescent; Adult; Arthritis, Rheumatoid; Body Fluids; Clinical Enzyme Tests; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Middle Aged; Multiple Myeloma; Muramidase; Pregnancy; Synovial Fluid; Waldenstrom Macroglobulinemia

Topics: Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphatic Diseases; Lymphocytes; Muramidase

Topics: Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Muramidase; Sepsis

Topics: Adolescent; Aged; Herpes Zoster; Humans; Leukemia, Lymphoid; Male; Middle Aged; Muramidase