muramidase and Hypergammaglobulinemia

A 30-year-old Japanese woman relapsed into sarcoidosis after two successive parturitions. The cutaneous lesions consisted of scar sarcoidosis, papular type, nodular type, and subcutaneous nodules with histologically typical "naked tubercles". Hypergammaglobulinemia, elevation of both serum angiotensin converting enzyme and lysozyme levels, and bilateral hilar lymphadenopathy were found in the acute and subacute stages, and spontaneously returned to normal levels 16 months after the onset. Our case suggests that parturition may trigger the onset of sarcoidosis.

Topics: Acute Disease; Adult; Female; Humans; Hypergammaglobulinemia; Labor, Obstetric; Muramidase; Peptidyl-Dipeptidase A; Pregnancy; Pregnancy Complications; Recurrence; Remission, Spontaneous; Sarcoidosis; Skin Diseases

A study was made of the disease pathogenesis in 58 patients with recurrent chronic erosions of the gastric mucosa. It has been established that an important role in the relapses of the pathological process is played by pathological microflora, disturbances in humoral immunity and local microcirculation, and long existence of the zone of fibrinoid necrosis.

Topics: Adult; Chronic Disease; Complement System Proteins; Enterococcus faecalis; Escherichia coli; Female; Gastric Mucosa; Humans; Hypergammaglobulinemia; Immunoglobulin G; Male; Middle Aged; Muramidase; Necrosis; Recurrence; Stomach Ulcer; Time Factors

The activity of non-specific protection factors (complement titer, lysozyme level, completed phagocytosis index and serum immunoglobulin (IG) concentration) was studied in 100 children, aged 3 to 14 years: 70 with diabetes mellitus and 30 normal subjects. The results obtained indicate a decreased reactivity of the child organism in diabetes mellitus, the reduction degree being directly proportional to the main process severity and decompensation extent. Serum IG level in children, suffering from diabetes mellitus, is disturbed, i.e. high IgA concentration is often seen in the presence of normal IgM level and normal or decreased IgG content. Disimmunoglobulinemia is intensified within decompensation phase, depending on the pathological process duration and severity. The reduced IgG level in patients with severe diabetes apart from lower indices of non-specific immunity, stipulates pred disposition of children with diabetes mellitus to the secondary infection development. The indices studied may be used not only for characterizing the body immunobiological reactivity and protective mechanisms, but also for determining the disease severity and form.

Topics: Adolescent; Child; Child, Preschool; Complement System Proteins; Diabetes Mellitus, Type 1; Dysgammaglobulinemia; Female; Humans; Hypergammaglobulinemia; IgG Deficiency; Immunoglobulin A; Male; Muramidase; Phagocytosis

Topics: Acidosis, Renal Tubular; Adult; Bicarbonates; Chromatography, DEAE-Cellulose; Female; Humans; Hydrogen-Ion Concentration; Hypergammaglobulinemia; Kidney Tubules, Distal; Muramidase; Proteinuria; Urine

Serum levels, urinary excretion, and clearances of several proteins of different molecular weights were studied in 18 patients with mono- and myelomonocytic leukemia. Nine patients had normal renal function (group A) and nine had impaired renal function with azotemia (group B). The majority of patients in both groups had increased concentration of immunoglobulins, particularly IgG, IgA, and IgM; IgD level was normal. Serum transferrin and alpha(2)-macroglobulin were frequently reduced while the level of ceruloplasmin was often increased, especially in patients with azotemia. The activity of lysozyme in the serum was high in all patients, but was considerably higher in group B. Proteinuria was found in most patients but was more prominent in group B. Almost invariably albumin constituted less than 25% of the total protein excreted. Qualitative analysis of various urinary proteins by immunochemical techniques and clearance studies suggested the presence of glomerular as well as tubular dysfunction. Determination of urinary lysozyme frequently showed no direct correlation between the serum level of the enzyme and its concentration in the urine or its clearance by the kidney. In addition to glomerular filtration, impaired tubular reabsorption may account for the high level of lysozyme in the urine. It is postulated that the very high level of lysozyme in the glomerular filtrate and possibly hypergammaglobulinemia may play a role in the induction of tubular damage. Renal impairment has been correlated with histological changes in the kidneys. From a comparative study of various leukemias, it seems that the combined glomerular-tubular dysfunction is a manifestation unique to mono- and myelomonocytic leukemia.

Topics: Adult; Agammaglobulinemia; Aged; Albuminuria; Blood Chemical Analysis; Blood Proteins; Ceruloplasmin; Female; Humans; Hypergammaglobulinemia; Immunoglobulins; Kidney Glomerulus; Kidney Tubules; Leukemia, Myeloid; Male; Middle Aged; Muramidase; Nitrogen; Proteinuria; Transferrin; Uremia