muramidase and Hashimoto-Disease

Follicular dendritic cell (FDC) sarcoma, especially of extranodal origin, is an extremely rare malignancy of FDC origin, with only 1 case previously documented in the thyroid. The authors report the case of a 58-year-old female who presented with a painless mass in her neck. The neoplastic cells expressed monocyte/macrophage-specific marker CD68 (KP-1) and lysozymes and the dendritic cell-associated antigens CD35 and Fascin but was negative for CD1a, CD21, and CD23, most consistent with a diagnosis of FDC sarcoma. BIOMED-2 multiplex polymerase chain reaction analysis showed B-cell clonality in both tumor and its adjacent coexisting Hashimoto's thyroiditis. To the authors' knowledge, this is the first report of a rare entity of FDC sarcoma primarily involving the thyroid gland coexisting with Hashimoto's thyroiditis.

Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; B-Lymphocytes; Biomarkers, Tumor; Carrier Proteins; Clone Cells; Dendritic Cell Sarcoma, Follicular; Female; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Hashimoto Disease; Humans; Microfilament Proteins; Middle Aged; Muramidase; Receptors, Complement 3b; Thyroid Neoplasms; Thyroidectomy