muramidase and Gastroenteritis

Topics: Female; Gastroenteritis; Humans; Immunoglobulin A; Infant; Infant, Newborn; Lactoferrin; Lactoglobulins; Milk, Human; Muramidase

The efficacy of antibiotic therapy of salmonellosis was studied and functional activity of peripheral blood leukocytes from electron microscopic data was estimated in 200 infants. It was shown that the use of antibiotics in combination with immunostimulants such as leukocyte mass, lysozyme and prodigiozan in complex therapy of salmonellosis in infants had a favourable effect on both the time course of the clinical signs and the functional state of the neutrophil leukocytes. The duration of the treatment decreased by 6.14 +/- 0.34 days and repeated isolation of the pathogen from the host appeared to be less frequent.

Topics: Ampicillin; Drug Therapy, Combination; Gastroenteritis; Humans; Immune Tolerance; Infant; Muramidase; Prodigiozan; Salmonella Infections; Salmonella typhimurium; Tobramycin

The authors describe the time-course of changes in local and general immunity as influenced by multimodality treatment in different groups of patients suffering from CGD and concomitant pancreatoduodenal pathology. It has been found that associated microbial and inflammatory process in the biliary system exerts a pronounced effect on the changes in immunologic parameters and that antibacterial therapy produces a beneficial action on the normalization of the parameters under consideration.

Topics: Adolescent; Child; Chronic Disease; Combined Modality Therapy; Duodenitis; Gastroenteritis; Humans; Immunoglobulins; Muramidase

Fecal lysozyme excretion was determined in two hundred children and adolescent. In sixty three infants with enteritis due to Rotavirus the fecal lysozyme level was found to be significant higher than in the feces of a group of healthy infants (p less than 0.01). Elevated fecal lysozyme excretion could be detected in patients with untreated Crohn's disease. After treatment with Salazosulfapyridine, Prednisone and elemental diet during six week a significant drop in fecal lysozyme level was observed (p less than 0.01). In eighteen adolescent with Colitis ulcerosa and Crohn's disease the lysozyme level of colonic mucosa was found to be significant higher than a control group (p less than 0.01). The fecal lysozyme excretion can be used as an indicator for the clinical activity of the disease, as a control for therapeutic efficiency and a marker for a relapse.

Topics: Adolescent; Adult; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Feces; Female; Gastroenteritis; Humans; Infant; Infant, Newborn; Intestinal Mucosa; Male; Muramidase; Rotavirus Infections

A study was made of some nonspecific immunity indices in staphylococcus sepsis and gastroenterocolitis during the infectious process in young children. Results of these investigations pointed to the depression of bactericidal and lysozyme activity of the blood serum and of the immunoadherence reaction at the acute period of the disease, and to some increase at the phase of recovery. There was also found an elevation of the phagocytic activity (of the phagocytolysis percentage) at the acute phase of the staphylococcus sepsis and gastroenterocolitis Antistaphylococcus gamma-globulin produced a positive effect on the lysozyme and bactericidal activity of the blood sera and promoted an increase of the blood phagocytic activity in the sick children.

Topics: Blood Bactericidal Activity; Enterocolitis, Pseudomembranous; Gastroenteritis; Immune Adherence Reaction; Male; Muramidase; Phagocytosis; Sepsis; Staphylococcal Infections