muramidase and Endometritis

The authors suggest new methods for the choice of drugs and physiotherapeutic modalities for the treatment of female genital inflammations, based on the suppression of the agents' antilysozymic activities, factors of the agent intracellular persistence. Clinical trials of these methods in 91 patients have shown their high efficacy: the incidence of complete remissions has increased by 60.7%, incidence of disease recurrences reduced by 53%, and remission periods in chronic patients were prolonged by 2.5-3 times (from 0.5-1 year to 2.5-3 years).

Topics: Anti-Bacterial Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Endometritis; Female; Humans; Muramidase; Oophoritis; Salpingitis

Exudate and uterine flushings were collected at either 30, 60, 120 or 240 mins after intrauterine infusions of Streptococcus zooepidemicus in genitally normal mares during oestrus. Uteri were also flushed without prior induction of endometritis. Protein concentrations in exudate and flushings increased with time and exudate pH decreased with time; the pH of flushings did not alter. Lysozyme and lactate dehydrogenase were present in flushings from non-infected uteri, but concentrations increased with time after infection. Immunoreactive prostaglandin E2 was undetectable before infection, but concentrations rose after infection. No neutrophils were present in non-infected flushings but, by 30 mins, there were significant (P less than 0.01) neutrophil numbers in exudate and flushings; thereafter numbers increased, particularly in exudate. Acute endometritis resembled acute inflammation at other sites in the horse and a significant response had occurred by 30 mins after experimental infection.

Topics: Animals; Chemotaxis, Leukocyte; Endometritis; Female; Horse Diseases; Horses; Hydrogen-Ion Concentration; Inflammation; L-Lactate Dehydrogenase; Leukocyte Count; Muramidase; Neutrophils; Prostaglandins E; Proteins; Uterus

Topics: Abortion, Septic; Adjuvants, Immunologic; Adult; Endometritis; Female; Humans; Lymphopenia; Muramidase; Pregnancy; T-Lymphocytes

Topics: Adult; Decompression; Endometritis; Female; Humans; Immunity, Innate; Lower Body Negative Pressure; Muramidase; Pelvic Inflammatory Disease; Pregnancy; Recurrence

Topics: Abortion, Septic; Adolescent; Adult; Anti-Bacterial Agents; Antitoxins; Carbenicillin; Cephalosporins; Complement System Proteins; Endometritis; Escherichia coli Infections; Female; Humans; Methicillin; Muramidase; Penicillin G; Pregnancy; Staphylococcal Infections; Streptococcal Infections; Tetracycline; Tetracyclines