muramidase and Duodenal-Ulcer

In 20 patients with active, endoscopically confirmed duodenal ulcer, serum lysozyme activity, metabolic and phagocytic activity of neutrophils using the NBT spontaneous and stimulated test and stimulated test, and cytoenzymatic reaction for alkaline phosphatase were evaluated before treatment and after two weeks of treatment with ranitidine 150 mg every 12 hours. In some of the studies carried out the differences were obtained between the mean results which turned out to be statistically significant. In the group of patients with duodenal ulcer after two weeks of treatment with ranitidine, a statistically significant increase was found of diluted serum lysozyme activity as compared to the activity of this enzyme before the treatment. After the treatment with ranitidine, a statistically highly significant increase was noted of alkaline phosphatase activity in the neutrophils as compared to the activity of this enzyme assessed in patients with untreated duodenal ulcer. On the basis of the obtained results of studies the conclusions were formulated: 1) The increase of diluted serum lysozyme activity in the patients with duodenal ulcer after two weeks of treatment with ranitidine may evidence the presence of inhibitors of the enzyme in the serum of the studied group. 2) In patients with duodenal ulcer after two weeks of treatment with ranitidine the activity increases of cytoenzymatically determined alkaline phosphatase in the neutrophils, while the cytoenzymatically determined values of the markers in the test with NBT remain unchanged.

Topics: Adult; Biomarkers; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Muramidase; Neutrophils; Ranitidine

The aim of our investigation was to study the influence of the systematic enzymotherapy on the results of surgical treatment of patients with duodenal ulcers. The immunological investigation was conducted on 77 patients with duodenal ulcers. The obtained results reveal the changes of immunological indexes in patients with duodenal ulcers. The process of rehabilitation with immunomodulative and enzymatic therapy after surgical treatment is analyzed and described.

Topics: Adjuvants, Immunologic; Adult; Combined Modality Therapy; Duodenal Ulcer; Enzyme Activators; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunomodulation; Levamisole; Male; Middle Aged; Muramidase; Preoperative Care; T-Lymphocytes, Helper-Inducer; Vagotomy, Proximal Gastric

The studies conducted for 126 patients with stomach and duodenal ulcers revealed that at the acute state of recurrent ulcer activation of the microflora displaying pathogenetic signs and corresponding to the third or fourth degree of dysbacteriosis takes place in the ulcerous defect zone along with microcirculatory disorders, necrotic inflammatory processes and reduction of the lysozyme content in tissues. This allows comparing ulcers of the gastroduodenal zone to an infected wound. At the sub-acute phase of recurrent ulcer (next one or two weeks) microbiological changes in the per-ulcer zone reduce to dysbacteriosis of the second or third degree as inflammatory and necrotic processes cease, an at the phase of cicatrisation and epithelization they are similar to normal biocenosis.

Topics: Acute Disease; Adult; Bacteria; Duodenal Ulcer; Female; Humans; Intestinal Mucosa; Male; Microcirculation; Middle Aged; Muramidase; Peptic Ulcer; Recurrence; Stomach Ulcer; Time Factors; Wound Infection

To investigate aggressive-protective factors in patients with erosive lesions of gastroduodenal mucosa.. Intragastric pH-metry, tests for Helicobacter pylori, lysozyme activity, content of bile acid in gastric juice, components of gastric mucous gel were made in 106 patients.. It is shown that there are two alternative paths of erosions development in the gastroduodenal zone: infectious and non-infectious.. In patients infected with Helicobacter pylori, lowering of a protective ability of the mucous gel is caused by prevalence of synthesis of immature mucous components while in non-infected patients this happens as a result of high catabolism of mucous components.

Topics: Adult; Bile Acids and Salts; Duodenal Ulcer; Duodenitis; Gastric Juice; Gastric Mucosa; Gastritis; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Middle Aged; Mucus; Muramidase; Peptic Ulcer; Stomach Ulcer

The study was concerned with measurement of lysozyme activity of saliva in healthy subjects and patients with different pathologies of the stomach including precancer and cancer. It established a considerable decrease in this parameter in cancer and precancer as compared with healthy controls. Assay of saliva lysozyme activity was found to yield more specific and prognostic data than clinical symptoms and examination of the patient. This procedure proved highly valuable in forming groups at risk for stomach cancer, due to providing significant differences in saliva lysozyme activity indices between "healthy subjects--stomach pathology" and "precancer--precancerous changes--stomach cancer" groups.

Topics: Clinical Enzyme Tests; Duodenal Ulcer; Duodenitis; Gastritis, Atrophic; Gastritis, Hypertrophic; Humans; Muramidase; Nephelometry and Turbidimetry; Precancerous Conditions; Prognosis; Risk Factors; Saliva; Sensitivity and Specificity; Stomach Neoplasms; Stomach Ulcer

Topics: Combined Modality Therapy; Duodenal Ulcer; Humans; Muramidase; Stomach Ulcer

Topics: Adult; Blood Bactericidal Activity; Duodenal Ulcer; Humans; Immunoglobulins; Lysine; Middle Aged; Muramidase; Stomach Ulcer

Lysozyme concentration in the gastric juice of 34 patients with peptic ulcer and 10 practically healthy persons was studied. In the patients with peptic ulcer the lysozyme levels in the gastric juice were found to be lower. A significant decrease in the lysozyme concentration was observed in the patients suffering from peptic ulcer for more than 2 years. During the first months of the disease increased levels of lysozyme were recorded. Relationship between the lysozyme concentration in the gastric juice and the acidity of the gastric contents was shown. Decreased concentrations of lysozyme were more pronounced in the patients with increased levels of hydrochloric acid.

Topics: Adolescent; Adult; Duodenal Ulcer; Enzyme Activation; Fasting; Female; Gastric Acidity Determination; Gastric Juice; Humans; Male; Middle Aged; Muramidase; Peptic Ulcer; Stomach Ulcer; Time Factors

Topics: Adult; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Muramidase; Stomach Ulcer

Topics: Adult; Autoantibodies; Complement System Proteins; Duodenal Ulcer; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Muramidase

The amylase:creatinine clearance ratio in patients suffering from acute pancreatitis or acute duodenal perforation was higher than normal in both groups of patients. These findings cast doubt on the value of this parameter as a specific index of acute pancreatitis. The mechanism or mechanisms underlying the increased amylase excretion have not been determined. However, the markedly elevated urinary excretion of lysozyme observed in some patients suggests, by analogy, that diminished tubular reabsorption of amylase may contribute towards the elevated amylase:creatinine ratio.

Topics: Acute Disease; Amylases; Creatinine; Duodenal Ulcer; Female; Humans; Male; Metabolic Clearance Rate; Muramidase; Pancreatitis; Peptic Ulcer Perforation

Topics: Duodenal Ulcer; Gastric Juice; Gastritis; Humans; Macromolecular Substances; Muramidase; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer