muramidase and Down-Syndrome

Topics: Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Carbohydrates; Citric Acid Cycle; Clinical Enzyme Tests; DNA; Down Syndrome; Galactosemias; Glucosephosphate Dehydrogenase Deficiency; Glycogen; Glycogen Storage Disease; Glycolysis; Glycosaminoglycans; Humans; Leukemia; Leukocytes; Muramidase; Neutrophils; Pentosephosphates; Phagocytosis; Propionates; RNA

A study of the immunoglobulin level in the 3 main classes (IgG, IgM and IgA) and lysozymes in the blood serum of 73 patients with Down's disease (from 5 to 20 years of age) showed an increase of IgG in the younger age (up to 7 years) and older groups (over 7 years). The content of IgM was significantly lower in the younger group and did not differ from the control indices in the older group. The level of IgA corresponded to normal indices. The studies demonstrated a marked drop in the lysozyme content. The role of the abnormal system of humoral immunity and reactions of nonspecific defense in the formation of predisposition to the development of infectious diseases in this form of pathology is discussed.

Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Down Syndrome; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Male; Muramidase

Topics: Adolescent; Bone Marrow Cells; Child; Child, Preschool; Down Syndrome; Endotoxins; Humans; Kinetics; Leukocyte Count; Leukocytes; Muramidase; Trisomy

Topics: Down Syndrome; Humans; Lacrimal Apparatus; Muramidase; Proteins; Tears