muramidase and Burning-Mouth-Syndrome

To compare different therapeutic supportive approaches in patients with burning mouth syndrome. A prospective study was carried out for this purpose.. The study involved 56 patients with burning mouth syndrome. They were randomly assigned to treatment with capsaicin, alpha-lipoic acid or lysozyme-lactoperoxidase (test drugs) or boric acid (control group). Symptoms were scored after 60 days treatment and 60 days after drug discontinuation.. At the end of the treatment period, there was a significant reduction in the symptom scores of all of the patients who received the test drugs (P<0.01), and at the end of the follow-up period in the test groups as a whole (P<0.01); the reduction was not significant when considering each test group separately after the treatment period. All of the treatments were more effective than boric acid and there was no significant difference in the symptom scores of the control group at either of the study time-points.. Our results demonstrate the similar effectiveness of capsaicin and alpha-lipoic acid in controlling the symptoms of burning mouth syndrome. Lysozyme-lactoperoxidase may be effective in the supportive care of BMS patients with xerostomia. The transitory effect observed after discontinuing drug administration justifies the use of prolonged therapy in chronically affected patients.

Topics: Administration, Oral; Administration, Topical; Antioxidants; Boric Acids; Burning Mouth Syndrome; Capsaicin; Female; Follow-Up Studies; Humans; Lactoperoxidase; Male; Middle Aged; Mouthwashes; Muramidase; Pain Measurement; Placebos; Prospective Studies; Sensory System Agents; Single-Blind Method; Tablets; Thioctic Acid

Alpha-lipoic acid (ALA) is a potent antioxidant mitochondrial coenzyme, trometamol salt of thioctic acid, shown in clinical studies to be neuroprotective and in a preliminary study to have an effect on the symptomatology of Burning Mouth Syndrome (BMS).. We were interested in extending our studies as to whether alpha-lipoic acid might improve the symptomatology in BMS and therefore carried out a larger open controlled clinical study on the effects of alpha-lipoic acid on BMS symptomatology.. We have examined the effects on 4 groups of 20 patients with BMS of ALA, compared with bethanecol, Biotene and placebo, and found ALA of remarkable benefit with minimal adverse effects.. These results suggest that double-blind randomized controlled multicenter studies of ALA are indicated.

Topics: Administration, Oral; Adult; Aged; Bethanechol; Burning Mouth Syndrome; Cohort Studies; Drug Combinations; Female; Glucose Oxidase; Humans; Lactoperoxidase; Male; Middle Aged; Mouthwashes; Muramidase; Neuroprotective Agents; Thioctic Acid; Treatment Outcome; Xylitol

In the current study, we performed taste and salivary analysis on patients suffering from burning mouth syndrome and xerostomia or taste disturbances.. A total of 180 patients who complained of idiopathic burning mouth syndrome (BMS) and taste aberrations and/or xerostomia that may accompany BMS were evaluated. These patients were compared with 90 healthy, age- and sex-matched controls. Salivary flow rate, biochemical and immunological analysis and taste acuity by the forced-choice drop technique were performed for all subjects. These analyses were found to be conclusive in distinguishing controls from patients with complaints.. The great similarity of both salivary and taste analysis in the BMS, taste aberration and xerostomia groups, which were significantly different from the results obtained in the control group, was found to be the most striking result. Higher salivary concentrations in the experimental group were consistent with a lower saliva (water) flow rate.. An oral neuropathy and/or neurological transduction interruption induced by salivary compositional alterations is suggested as the possible aetiology for the complaints. This report may add an important objective diagnostic tool to the clinician treating these patients.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albumins; Burning Mouth Syndrome; Female; Humans; Immunoglobulins; Male; Middle Aged; Muramidase; Saliva; Salivary Proteins and Peptides; Salivation; Sodium; Taste; Taste Disorders; Xerostomia