muramidase and Anemia--Hypochromic

Iron lysozyme glutarate (ABC 1020) is a new soluble complex with an anti-anaemic activity superior to that of ferritin, ferrous sulphate and iron succinyl protein. Iron serum concentrations after treatment with ABC 1020 are higher than after ferritin and iron succinyl protein and lower than after ferrous sulphate treatment. Anaemic adult rats and rats born from dams with anaemia induced by an iron-deficient diet and by repeated bleeding showed considerable, dose-related improvement when treated with ABC 1020, which gave markedly better results than ferritin, iron succinyl protein and ferrous sulphate. Treatment with all four compounds improved the hematological and blood chemistry parameters considered, and reversed cardio- and splenomegaly. Preliminary data show that ABC 1020 is well tolerated, does not induce gastric lesions and has a high bioavailability.

Topics: Anemia, Hypochromic; Animals; Chromatography, High Pressure Liquid; Electrophoresis, Cellulose Acetate; Female; Glutarates; Hydrogen-Ion Concentration; Iron; Kinetics; Male; Muramidase; Rats; Rats, Inbred Strains; Solubility; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

Topics: Adolescent; Anemia, Hypochromic; Blood Bactericidal Activity; Child; Child, Preschool; Humans; Muramidase; Neutrophils; Phagocytosis

Iron deficiency anaemia was induced in rabbits by repeated bleeding. The leucocyte alkaline phosphatase (LAP) of 26 +/- 28 units was significantly reduced compared with control values of 233 +/- 35 units (P less than 0.001). Leucocyte NBT reduction was also diminished, both in Hanks solution (P less than 0.01) and in autologous serum (P less than 0.001). After administration of iron, these values returned to normal. The results suggest that reduced LAP may reflect a deficiency of iron dependent constituents which are necessary for the integrity of normal granulocyte metabolism.

Topics: Alkaline Phosphatase; Anemia, Hypochromic; Animals; Escherichia coli; Granulocytes; Hemoglobins; Iron; Leukocytes; Male; Muramidase; Nitroblue Tetrazolium; Rabbits; Transferrin

Fats were fed either diets sufficient (300 ppm) or insufficient (5 ppm) in iron for 10 weeks. The iron-deficient animals had lowered hemoglobin and hematocrit levels and higher levels of kidney lysozyme activity than did control animals. There were no significant changes in serum and spleen lysozyme activity levels.

Topics: Anemia, Hypochromic; Animals; Female; Muramidase; Rats; Tissue Distribution