muramidase and Adenoviridae-Infections

muramidase has been researched along with Adenoviridae-Infections* in 2 studies

Other Studies

2 other study(ies) available for muramidase and Adenoviridae-Infections

ArticleYear
Differential T-cell activation by B7-1 expression.
    Immunology, 2003, Volume: 109, Issue:3

    T-cell receptor-mediated T-cell activation requires cosimulation signal, which can be provided by B7-1 molecule. Our previous study demonstrated that the coexpression of a covalent peptide/major histocompatibility complex class II molecule complex and costimulatory molecule B7-1 by recombinant adenovirus leads to synergy in peptide-specific T-cell activation. However, the viral antigen-specific T-cell activation is not enhanced by B7-1 expressed by the adenovirus. To verify the differential T cell activation by B7-1 and investigate its underlying mechanisms, we constructed an adenovirus coexpressing a covalent complex of hen egg lysozyme peptide/I-Ak (HEL46-61/I-Ak) and B7-1 in the present study. In vivo studies revealed that HEL46-61-specific T-cell response, but not viral antigen-specific T-cell response, was enhanced by B7-1 expression mediated by the adenovirus, suggesting that exogenous B7-1 expression may regulate T-cell response to these two different antigens through distinct mechanisms. Furthermore, our results revealed that antigen-presenting cells were not susceptible to adenovirus infection in vivo. Based on these findings, the possible mechanism of differential B7-1 costimulation on peptide-specific and viral antigen-specific T-cell activation is discussed.

    Topics: Adenoviridae; Adenoviridae Infections; Amino Acid Sequence; Animals; Antigen-Presenting Cells; Antigens, Viral; B7-1 Antigen; Blotting, Northern; Cells, Cultured; Gene Transfer Techniques; Lymphocyte Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Muramidase; Peptide Fragments; T-Lymphocytes

2003
Immunoassay of tear lysozyme in acute adenovirus conjunctivitis.
    The British journal of ophthalmology, 1986, Volume: 70, Issue:6

    The tear lysozyme levels were measured by immunoassay in 92 healthy subjects and 98 patients with acute adenovirus conjunctivitis. They were found to be significantly decreased during the acute phase of the disease. The extent of this decline in the tear lysozyme level was correlated with increased severity of disease. There was no significant difference in the tear lysozyme level in viral isolation-positive and isolation-negative patients. The tear lysozyme level showed return to normal levels with clinical improvement.

    Topics: Acute Disease; Adenoviridae Infections; Adolescent; Adult; Child; Child, Preschool; Conjunctivitis, Viral; Female; Humans; Immunoassay; Male; Middle Aged; Muramidase; Tears

1986