muramidase and Adenolymphoma

Presence of lysozyme, lactoferrin, alpha 1-antitrypsin, alpha 1-antichymotrypsin and ferritin was examined by the immunoperoxidase method in 15 consecutive parotid gland tumors as well as in normal parotid gland tissue. Lysozyme and lactoferrin were detected in intercalated duct cells of normal tissue and in the epithelial component of pleomorphic adenomas. alpha 1-antitrypsin, alpha 1-antichymotrypsin and ferritin were found in both epithelial and mesenchymal components of pleomorphic adenomas but not in normal parotid tissue. In the epithelial component of adenolymphoma only alpha 1-antichymotrypsin and lactoferrin were observed. The results would support a tentative histogenetic link between the intercalated duct cell and the epithelial component of the pleomorphic adenoma.

Topics: Adenocarcinoma; Adenolymphoma; Adenoma, Pleomorphic; alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Chymotrypsin; Ferritins; Histocytochemistry; Humans; Immunoenzyme Techniques; Lactoferrin; Lactoglobulins; Muramidase; Parotid Neoplasms

7 patients with uni- and bilateral Whartin tumors are examined. In comparison to sialographic and scintigraphic findings simultaneous estimations of flowrate, total protein, immunoglobulin A and lysozyme excretion of these glands in rest and under stimulation are done. Thereby the following results were found: 1. Flowrate is normal like in glands with pleomorphic adenomas. 2. Total protein secretion is significant lower in stimulated secretions. 3. Immunoglobulin A secretion is diminished in stimulated secretions, lysozyme is diminished under rest and stimulation.

Topics: Adenolymphoma; Antibody Formation; Blood Proteins; Female; Humans; Immunoglobulins; Male; Muramidase; Neoplasm Proteins; Parotid Neoplasms; Radionuclide Imaging; Sialography