mupirocin and Otitis-Media-with-Effusion

Only a few medications have a United States Food and Drug Administration indications for prevention and/or treatment of infections in patients with tympanic perforations or tympanostomy tubes. We examined 3 off-label agents that have become important in tympanostomy tube care hoping to demonstrate the effectiveness and safety of each in experimental assays and human application.. Computerized literature review.. (1) Oxymetazoline nasal spray applied at the time of surgery is equivalent to fluoroquinolone ear drops in the prevention of early postsurgical otorrhea and tympanostomy tube occlusion at the first postoperative visit. (2) Topical mupirocin 2% ointment is effective alone or in combination with culture-directed systemic therapy for the treatment of tympanostomy tube otorrhea caused by community-acquired, methicillin-resistant. Oxymetazoline nasal spray, mupirocin ointment, and clotrimazole cream are safe and effective as off-label medications for tympanostomy tube care in children.

Topics: Administration, Topical; Anti-Bacterial Agents; Antibiotic Prophylaxis; Child; Child, Preschool; Clotrimazole; Female; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Middle Ear Ventilation; Mupirocin; Nasal Sprays; Off-Label Use; Otitis; Otitis Media with Effusion; Oxymetazoline; Prosthesis-Related Infections; Staphylococcal Infections