mupirocin and Mediastinitis

Although presurgical nasal decontamination with mupirocin (NDM) has been advocated as a measure for preventing postsurgical mediastinitis (PSM) due to Staphylococcus aureus, this strategy is not universally recommended due to lack of robust supporting evidence. We aimed to evaluate the role of preoperative NDM in the annual incidence of S. aureus PSM at our institution.. An interrupted time-series analysis, with an autoregressive error model, was applied to our single-center cohort by comparing preintervention (1990-2003) and postintervention (2005-2018) periods. Logistic regression was performed to analyze risk factors for S. aureus PSM.. 12 236 sternotomy procedures were analyzed (6370 [52.1%] and 5866 [47.9%] in the pre- and postintervention periods, respectively). The mean annual percentage adherence to NDM estimated over the postintervention period was 90.2%. Only 4 of 127 total cases of S. aureus PSM occurred during the 14-year postintervention period (0.68/1000 sternotomies vs 19.31/1000 in the preintervention period; P < .0001). Interrupted time-series analysis demonstrated a statistically significant annual reduction in S. aureus PSM of -9.85 cases per 1000 sternotomies (-13.17 to -6.5; P < .0001) in 2005, with a decreasing trend maintained over the following 5 years and an estimated relative reduction of 84.8% (95% confidence interval [CI], 89.25-74.09%). Chronic obstructive pulmonary disease was the single independent risk factor for S. aureus PSM (odds ratio, 3.7; 95% CI, 1.72-7.93) and was equally distributed in patients undergoing sternotomy during pre- or postintervention periods.. Our experience suggests the implementation of preoperative NDM significantly reduces the incidence of S. aureus PSM.

Topics: Anti-Bacterial Agents; Carrier State; Decontamination; Humans; Mediastinitis; Mupirocin; Staphylococcal Infections; Staphylococcus aureus; Sternotomy; Surgical Wound Infection

Surgical site infections after cardiac surgery are associated with severe outcomes, including reoperation and death. We aimed to describe the effect of a standardized clinical-care protocol for preventing mediastinitis in patients who underwent coronary artery bypass graft surgery (CABG).. In a hospital certified by Joint Commission International, all patients who underwent CABG from January 2011 to December 2016 were compared in two periods according to the moment of implementation of a standardized clinical-care protocol for prevention of mediastinitis (CCPPM): pre-protocol (January 2011-December 2012) and post-protocol (January 2013-December 2016). The CCPPM consisted of the patient using a kit containing chlorhexidine 2% for bathing, mupirocin 20 mg/g for nasal topical use and chlorhexidine 0.12% for oral hygiene for 5 days before surgery, in addition to prophylaxis with a glycopeptide antimicrobial and strict glucose control (110-140 mg/dL) during surgery and immediate postoperative.. We evaluated 1760 patients who underwent CABG in both periods. The occurrence of mediastinitis before protocol implementation was 1.44% (10 of 692 CABG). After the implementation of the protocol, there was an important reduction in the incidence of mediastinitis to 0.09% (1 of 1068 CABG) (P = 0.002). Although we did not observe a significant difference in mortality between the groups (2.3% vs 1%, P = 0.77), there was fewer in-hospital mortality due to mediastinitis after the CCPPM (0.2% vs 0%, P < 0.001).. Implementation of a standardized CCPPM was associated with a significant reduction in the incidence of mediastinitis after CABG and reduction of mortality in the group of patients with mediastinitis.

Topics: Administration, Topical; Aged; Antibiotic Prophylaxis; Baths; Chlorhexidine; Coronary Artery Bypass; Female; Hospital Mortality; Hospitals, Private; Humans; Incidence; Male; Mediastinitis; Middle Aged; Mupirocin; Oral Hygiene; Patient Care; Postoperative Complications; Quality of Health Care; Time Factors

Postoperative mediastinitis belongs to one of the severest complications of cardiosurgical operations. There have been suggested many methods of pre- and intraoperative prevention of sternal infection. Summarizing the obtained experience, in 2006 specialists of the EurAsia Heart Foundation under the leadership of Professor P. Vogt (Im Park Clinic, Zurich, Switzerland) elaborated and suggested a methodology of eliminating sternal infection, which according to the author s opinion made it possible to decrease the frequency of the development of sternal infection from 5.6 to 0%. This methodology was implemented at the Federal Centre of Cardiovascular Surgery (city of Penza) in July 2012, thus leading to a decrease in the rate of wound complications from 4.05 to 0.3%.

Topics: Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cardiac Surgical Procedures; Cardiovascular Diseases; Comparative Effectiveness Research; Female; Humans; Male; Mediastinitis; Middle Aged; Mupirocin; Outcome and Process Assessment, Health Care; Perioperative Care; Retrospective Studies; Sternum; Surgical Wound Infection; Suture Techniques