mulundocandin and Candidiasis

mulundocandin has been researched along with Candidiasis* in 2 studies

Other Studies

2 other study(ies) available for mulundocandin and Candidiasis

Article	Year
Approaches towards the stabilization of hemiaminal function at ornithine unit of mulundocandin. Bioorganic & medicinal chemistry letters, 2004, Mar-08, Volume: 14, Issue:5 Semisynthetic modifications at position-12 (ornithine-5-position, hemiaminal function) of mulundocandin were carried out to improve its chemical stability. New carbon-carbon (C-C) and carbon-hydrogen (C-H) linkage at hemiaminal function -12 has been achieved. Lewis acid catalyzed introduction of electron rich aryl group at position-12 of mulundocandin is developed. Synthesized mulundocandin analogues were evaluated for their chemical stability and antifungal activity against C. albicans and A. fumigatus. Topics: Amines; Animals; Antifungal Agents; Candida albicans; Candidiasis; Drug Stability; Echinocandins; Injections, Intraperitoneal; Mice; Ornithine; Peptides, Cyclic	2004
Mannich reaction: an approach for the synthesis of water soluble mulundocandin analogues. Bioorganic & medicinal chemistry, 2004, Apr-01, Volume: 12, Issue:7 Semisynthetic modifications at Hydroxy tyrosine (Htyr) unit of mulundocandin (1) were carried out to improve its aqueous solubility. A single step introduction of substituted aminomethyl groups at the ortho position(s) of phenolic hydroxyl of HTyr unit of mulundocandin has been achieved in 7-85% yield. The in vitro screening of Mannich products against Candida albicans and Aspergillus fumigatus, retained the in vivo activity of parent by oral and intraperitoneal route. Compound 20, showed significant improvement in activity over mulundocandin (1) and activity compares well with that of fluconazole. Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Disease Models, Animal; Drug Evaluation, Preclinical; Echinocandins; Mannich Bases; Mice; Microbial Sensitivity Tests; Models, Animal; Molecular Structure; Peptides, Cyclic; Solubility; Water	2004

Article

Year

Approaches towards the stabilization of hemiaminal function at ornithine unit of mulundocandin.

Bioorganic & medicinal chemistry letters, 2004, Mar-08, Volume: 14, Issue:5

Semisynthetic modifications at position-12 (ornithine-5-position, hemiaminal function) of mulundocandin were carried out to improve its chemical stability. New carbon-carbon (C-C) and carbon-hydrogen (C-H) linkage at hemiaminal function -12 has been achieved. Lewis acid catalyzed introduction of electron rich aryl group at position-12 of mulundocandin is developed. Synthesized mulundocandin analogues were evaluated for their chemical stability and antifungal activity against C. albicans and A. fumigatus.

Topics: Amines; Animals; Antifungal Agents; Candida albicans; Candidiasis; Drug Stability; Echinocandins; Injections, Intraperitoneal; Mice; Ornithine; Peptides, Cyclic

2004

Mannich reaction: an approach for the synthesis of water soluble mulundocandin analogues.

Bioorganic & medicinal chemistry, 2004, Apr-01, Volume: 12, Issue:7

Semisynthetic modifications at Hydroxy tyrosine (Htyr) unit of mulundocandin (1) were carried out to improve its aqueous solubility. A single step introduction of substituted aminomethyl groups at the ortho position(s) of phenolic hydroxyl of HTyr unit of mulundocandin has been achieved in 7-85% yield. The in vitro screening of Mannich products against Candida albicans and Aspergillus fumigatus, retained the in vivo activity of parent by oral and intraperitoneal route. Compound 20, showed significant improvement in activity over mulundocandin (1) and activity compares well with that of fluconazole.

Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Disease Models, Animal; Drug Evaluation, Preclinical; Echinocandins; Mannich Bases; Mice; Microbial Sensitivity Tests; Models, Animal; Molecular Structure; Peptides, Cyclic; Solubility; Water

2004