muconomycin-a has been researched along with Candidiasis* in 1 studies
1 other study(ies) available for muconomycin-a and Candidiasis
| Article | Year |
|---|---|
Therapeutic effects of three trichothecenes in the silkworm infection assay with Candida albicans.
The silkworm infection assay is a useful method for directly evaluating the in vivo therapeutic effects of drug candidates. In the present study, 3 known trichothecenes, trichodermin, epiisororidin E, and verrucarin A, were evaluated as antifungal agents in the silkworm-Candida albicans assay. Trichodermin and epiisororidin E yielded effective therapeutic effects, while verrucarin A exhibited no efficacy in this assay system. These results strongly suggest that trichodermin and epiisororidin E are the lead compounds for developing a new antifungal agent. Topics: Animals; Antifungal Agents; Bombyx; Candida albicans; Candidiasis; Cell Survival; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Humans; Larva; Trichodermin; Trichothecenes | 2016 |