mtt-formazan and Leukemia-L5178

mtt-formazan has been researched along with Leukemia-L5178* in 1 studies

Other Studies

1 other study(ies) available for mtt-formazan and Leukemia-L5178

Article	Year
In vitro apoptotic activity of 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones in L5178Y cells. Life sciences, 2007, Feb-20, Volume: 80, Issue:11 Compounds containing B-N bonds have shown interesting biological activity. One class of such molecules is the 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones (3a-j), which contain a B-N bond, have an alpha-amino acid moiety in the heterocycle, and have an exocyclic moiety related to an amino acid. The purpose of this work was to determine the inhibitory effects of 3a-j on the proliferation of murine L5178Y lymphoma cells. A new five-membered heterocyclic nucleus with apoptotic activity was found. The target products showed potent cytotoxicity in the L5178Y cell line. Among them, 3a exhibited the highest antineoplastic activity in L5178Y cells with an IC(50) value of 22.5+/-0.2 microM. Topics: Animals; Antineoplastic Agents; Apoptosis; Boron Compounds; Cell Proliferation; Cell Survival; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flow Cytometry; Formazans; Inhibitory Concentration 50; Leukemia L5178; Mice; Mice, Inbred BALB C; Phosphatidylserines; Tetrazolium Salts	2007

Article

Year

In vitro apoptotic activity of 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones in L5178Y cells.

Life sciences, 2007, Feb-20, Volume: 80, Issue:11

Compounds containing B-N bonds have shown interesting biological activity. One class of such molecules is the 2,2-diphenyl-1,3,2-oxazaborolidin-5-ones (3a-j), which contain a B-N bond, have an alpha-amino acid moiety in the heterocycle, and have an exocyclic moiety related to an amino acid. The purpose of this work was to determine the inhibitory effects of 3a-j on the proliferation of murine L5178Y lymphoma cells. A new five-membered heterocyclic nucleus with apoptotic activity was found. The target products showed potent cytotoxicity in the L5178Y cell line. Among them, 3a exhibited the highest antineoplastic activity in L5178Y cells with an IC(50) value of 22.5+/-0.2 microM.

Topics: Animals; Antineoplastic Agents; Apoptosis; Boron Compounds; Cell Proliferation; Cell Survival; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flow Cytometry; Formazans; Inhibitory Concentration 50; Leukemia L5178; Mice; Mice, Inbred BALB C; Phosphatidylserines; Tetrazolium Salts

2007