mrs-1754 and Asthma

mrs-1754 has been researched along with Asthma* in 1 studies

Other Studies

1 other study(ies) available for mrs-1754 and Asthma

Article	Year
The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma. Bioorganic & medicinal chemistry letters, 2005, Feb-01, Volume: 15, Issue:3 Adenosine has been suggested to play a role in asthma, possibly via activation of A(2B) adenosine receptors on mast cells and other pulmonary cells. We describe our initial efforts to discover a xanthine based selective A(2B) AdoR antagonist that resulted in the discovery of CVT-5440, a high affinity A(2B) AdoR antagonist with good selectivity (A(2B) AdoR K(i)=50 nM, selectivity A(1)>200: A(2A)>200: A(3)>167). Topics: Adenosine A2 Receptor Antagonists; Asthma; Drug Stability; Humans; Liver; Structure-Activity Relationship; Xanthines	2005

Article

Year

The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma.

Bioorganic & medicinal chemistry letters, 2005, Feb-01, Volume: 15, Issue:3

Adenosine has been suggested to play a role in asthma, possibly via activation of A(2B) adenosine receptors on mast cells and other pulmonary cells. We describe our initial efforts to discover a xanthine based selective A(2B) AdoR antagonist that resulted in the discovery of CVT-5440, a high affinity A(2B) AdoR antagonist with good selectivity (A(2B) AdoR K(i)=50 nM, selectivity A(1)>200: A(2A)>200: A(3)>167).

Topics: Adenosine A2 Receptor Antagonists; Asthma; Drug Stability; Humans; Liver; Structure-Activity Relationship; Xanthines

2005