moxonidine has been researched along with Myocardial Ischemia in 5 studies
moxonidine: structure given in first source
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Moxonidine was well tolerated in this single-dose study and resulted in a modest, dose-dependent, vasodilator response, with substantial reductions in systemic and pulmonary arterial blood pressure." | 6.69 | Acute hemodynamic and neurohumoral effects of moxonidine in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Aarsland, T; Dickstein, K; Køpp, U; Manhenke, C; McNay, J; Wiltse, C, 1999) |
| "Moxonidine was well tolerated in this single-dose study and resulted in a modest, dose-dependent, vasodilator response, with substantial reductions in systemic and pulmonary arterial blood pressure." | 2.69 | Acute hemodynamic and neurohumoral effects of moxonidine in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. ( Aarsland, T; Dickstein, K; Køpp, U; Manhenke, C; McNay, J; Wiltse, C, 1999) |
| "Moxonidine has been shown to be antiarrhythmic during ischaemia in vivo." | 1.30 | Facilitation of spontaneous defibrillation by moxonidine during regional ischaemia in an isolated working rabbit heart model. ( Cobbe, SM; Hicks, MN; Kane, KA; Wolk, R, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Kerckhoven, R | 1 |
| Saxena, PR | 1 |
| Schoemaker, RG | 1 |
| Dikow, R | 1 |
| Kihm, LP | 1 |
| Zeier, M | 1 |
| Kapitza, J | 1 |
| Törnig, J | 1 |
| Amann, K | 1 |
| Tiefenbacher, C | 1 |
| Ritz, E | 1 |
| Bolliger, D | 1 |
| Seeberger, MD | 1 |
| Lurati Buse, GA | 1 |
| Christen, P | 1 |
| Gürke, L | 1 |
| Filipovic, M | 1 |
| Wolk, R | 1 |
| Kane, KA | 1 |
| Cobbe, SM | 1 |
| Hicks, MN | 1 |
| Dickstein, K | 1 |
| Manhenke, C | 1 |
| Aarsland, T | 1 |
| Køpp, U | 1 |
| McNay, J | 1 |
| Wiltse, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Small Doses of Moxonidine in Patients Undergoing Vascular Surgery[NCT00244504] | Phase 3 | 141 participants (Actual) | Interventional | 2002-11-30 | Terminated (stopped due to Study was stopped after pre-definied interim analysis because of no effects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for moxonidine and Myocardial Ischemia
| Article | Year |
|---|---|
Randomized clinical trial of moxonidine in patients undergoing major vascular surgery.
Topics: Aged; Coronary Artery Disease; Double-Blind Method; Female; Hemodynamics; Hospitalization; Humans; I | 2007 |
Acute hemodynamic and neurohumoral effects of moxonidine in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
Topics: Administration, Oral; Aged; Analysis of Variance; Antihypertensive Agents; Cardiomyopathy, Dilated; | 1999 |
3 other studies available for moxonidine and Myocardial Ischemia
| Article | Year |
|---|---|
Restored capillary density in spared myocardium of infarcted rats improves ischemic tolerance.
Topics: Animals; Capillaries; Imidazoles; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Ische | 2002 |
Increased infarct size in uremic rats: reduced ischemia tolerance?
Topics: Animals; Body Weight; Coronary Vessels; Heart Ventricles; Hydralazine; Imidazoles; Ischemia; Male; M | 2004 |
Facilitation of spontaneous defibrillation by moxonidine during regional ischaemia in an isolated working rabbit heart model.
Topics: Action Potentials; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Disease Models, Animal; E | 1999 |