moxonidine has been researched along with Hypotension in 10 studies
moxonidine: structure given in first source
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current data demonstrate that GABAergic mechanisms in the RVLM are responsible for the hypotension and sympathoinhibition of moxonidine." | 7.77 | GABAergic mechanism in the rostral ventrolateral medulla contributes to the hypotension of moxonidine. ( Ni, X; Peng, JF; Su, DF; Sun, T; Wang, W; Wang, WZ; Wang, YK; Wu, ZT; Xu, MJ; Yuan, WJ, 2011) |
| "The current data demonstrate that GABAergic mechanisms in the RVLM are responsible for the hypotension and sympathoinhibition of moxonidine." | 3.77 | GABAergic mechanism in the rostral ventrolateral medulla contributes to the hypotension of moxonidine. ( Ni, X; Peng, JF; Su, DF; Sun, T; Wang, W; Wang, WZ; Wang, YK; Wu, ZT; Xu, MJ; Yuan, WJ, 2011) |
| "In the present study, we investigated the effects of pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) (nitric oxide synthase inhibitor) injected intravenously (IV) on the hypotension, bradycardia, and vasodilation produced by moxonidine (alpha2-adrenergic/imidazoline receptor agonist) injected into the fourth brain ventricle (4th V) in rats submitted to acute hypertension that results from baroreflex blockade by bilateral injections of kynurenic acid (kyn, glutamatergic receptor antagonist) into the nucleus of the solitary tract (NTS) or in normotensive rats." | 3.73 | Antihypertensive responses elicited by central moxonidine in rats: possible role of nitric oxide. ( Colombari, E; Menani, JV; Moreira, TS; Sato, MA; Takakura, AC, 2006) |
| "Pretreatment with moxonidine abolished the hypotensive but not the tachycardic effect of ethanol." | 1.38 | Adenosinergic modulation of the imidazoline I₁-receptor-dependent hypotensive effect of ethanol in acute renal failure. ( El-Gowelli, HM; El-Mas, MM; Ghazal, AR; Harraz, OF; Mohy El-Din, MM, 2012) |
| "Moxonidine is a centrally-active imidazoline compound with preferential affinity for imidazoline receptors (IR) over alpha(2)-adrenoceptors (alpha(2)AR)." | 1.32 | Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses. ( Paul, IA; Peeler, DF; Piletz, JE; Stec, DE; Zhu, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, JF | 1 |
| Wu, ZT | 1 |
| Wang, YK | 1 |
| Yuan, WJ | 1 |
| Sun, T | 1 |
| Ni, X | 1 |
| Su, DF | 1 |
| Wang, W | 1 |
| Xu, MJ | 1 |
| Wang, WZ | 1 |
| Harraz, OF | 1 |
| El-Gowelli, HM | 1 |
| Mohy El-Din, MM | 1 |
| Ghazal, AR | 1 |
| El-Mas, MM | 1 |
| Zhu, H | 2 |
| Paul, IA | 1 |
| Stec, DE | 1 |
| Peeler, DF | 1 |
| Piletz, JE | 2 |
| Moreira, TS | 2 |
| Takakura, AC | 2 |
| Menani, JV | 2 |
| Sato, MA | 2 |
| Colombari, E | 2 |
| Chan, CK | 1 |
| Burke, SL | 1 |
| Head, GA | 1 |
| Molderings, GJ | 1 |
| Bönisch, H | 1 |
| Brüss, M | 1 |
| Wolf, C | 1 |
| von Kügelgen, I | 1 |
| Göthert, M | 1 |
| Zhu, QM | 1 |
| Lesnick, JD | 1 |
| Jasper, JR | 1 |
| MacLennan, SJ | 1 |
| Dillon, MP | 1 |
| Eglen, RM | 1 |
| Blue, DR | 1 |
| Medvedev, OS | 2 |
| Kunduzova, OR | 1 |
| Murashev, AN | 2 |
| Medvedeva, NA | 1 |
| Khokhlova, ON | 1 |
10 other studies available for moxonidine and Hypotension
| Article | Year |
|---|---|
GABAergic mechanism in the rostral ventrolateral medulla contributes to the hypotension of moxonidine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; GABA-A Receptor Antagonists; GA | 2011 |
Adenosinergic modulation of the imidazoline I₁-receptor-dependent hypotensive effect of ethanol in acute renal failure.
Topics: Acute Kidney Injury; Adenosine; Animals; Ethanol; Hypotension; Imidazoles; Imidazoline Receptors; Ma | 2012 |
Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepi | 2003 |
Central blockade of nitric oxide synthesis reduces moxonidine-induced hypotension.
Topics: Animals; Bradycardia; Brain Stem; Brazil; Drug Combinations; Echocardiography, Doppler, Pulsed; Four | 2004 |
Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine.
Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Animals; Antihypertensive Agents; Blotting, Western; Bra | 2005 |
Antihypertensive responses elicited by central moxonidine in rats: possible role of nitric oxide.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradycardia; Drug Interactions; Endoth | 2006 |
S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands.
Topics: Animals; Antihypertensive Agents; Binding, Competitive; Calcium Signaling; Clonidine; Down-Regulatio | 2007 |
alpha 2A-adrenoceptors, not I1-imidazoline receptors, mediate the hypotensive effects of rilmenidine and moxonidine in conscious mice. In vivo and in vitro studies.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cell Line; Dogs; Guanosine 5'-O-(3-Thiotriphosphat | 1999 |
Influence of sinoaortic barodenervation on the hypotensive effects of imidazoline-like drugs in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Cloni | 1999 |
Role of the rostroventrolateral medulla in moxonidine-induced changes in cardiochronotropic regulation.
Topics: Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Heart; Hypotension; Imidazoles; | 2001 |