moxonidine and Drug Withdrawal Symptoms studies

Research Excerpts

Excerpt	Relevance	Reference
"Present study investigated the role of agmatine in ethanol-induced anxiolysis and withdrawal anxiety using elevated plus maze (EPM) test in rats."	7.76	Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats. ( Chopde, CT; Kotagale, NR; Patel, MR; Shelkar, GP; Taksande, BG; Ugale, RR, 2010)
"Present study investigated the role of agmatine in ethanol-induced anxiolysis and withdrawal anxiety using elevated plus maze (EPM) test in rats."	3.76	Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats. ( Chopde, CT; Kotagale, NR; Patel, MR; Shelkar, GP; Taksande, BG; Ugale, RR, 2010)
"Moxonidine is a selective I1-imidazoline receptor agonist, similar to clonidine but with no α2-adrenergic agonist activity and subsequently fewer side effects."	1.42	Moxonidine for tramadol withdrawal symptoms during detoxification. ( Ghossoub, E; Talih, F, 2015)
"Pretreatment with moxonidine (0."	1.31	Moxonidine, a selective imidazoline-1 receptor agonist, suppresses the effects of ethanol withdrawal on the acoustic startle response in rats. ( Kallman, MJ; Rasmussen, K; Vandergriff, J, 2000)

Research

Studies (6)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change in Blood Pressure After Intrathecal Injection of Clonidine.

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (16.67)	18.7374
1990's	2 (33.33)	18.2507
2000's	1 (16.67)	29.6817
2010's	2 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Talih, F	1
Ghossoub, E	1
Taksande, BG	1
Kotagale, NR	1
Patel, MR	1
Shelkar, GP	1
Ugale, RR	1
Chopde, CT	1
Plänitz, V	1
Rupp, H	1
Maisch, B	1
Brilla, CG	1
Webster, J	1
Koch, HF	1
Vandergriff, J	1
Kallman, MJ	1
Rasmussen, K	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335]	Phase 2	10 participants (Actual)	Interventional	2011-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection

Changes in Visual Analogue Scale (VAS) Ratings of Sedation and Sensation of Dry Mouth Reported by the Subjects, Pre and 1 Hour Post Injection

Intervention	mm Hg (Mean)
	Change in mean SBP after clonidine injection	Change in DBP after clonidine injection
Intrathecal Clonidine	79	37

Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.

Likert Scale Pain Rating

Intervention	cm (Mean)
	Change in level of sedation	Change in sensation of dry mouth
Intrathecal Clonidine	3.36	3.47

Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.

Intervention	units on a scale (Mean)
	Pre-injection average Likert score	Post-injection average Likert score
Intrathecal Clonidine	6.5	3.6

Article	Year
Moxonidine for tramadol withdrawal symptoms during detoxification. BMJ case reports, 2015, Jul-08, Volume: 2015 Topics: Adult; Analgesics, Opioid; Antihypertensive Agents; Female; Humans; Imidazoles; Imidazoline Receptor	2015
Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats. European journal of pharmacology, 2010, Jul-10, Volume: 637, Issue:1-3 Topics: Agmatine; Animals; Anti-Anxiety Agents; Anxiety; Arginine; Biguanides; Brain; Clonidine; Dose-Respon	2010
Drug withdrawal and rebound hypertension: differential action of the central antihypertensive drugs moxonidine and clonidine. Cardiovascular drugs and therapy, 1996, Volume: 10 Suppl 1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Heart Rate; Hypertension; Imidazoles; R	1996
Moxonidine, a selective imidazoline-1 receptor agonist, suppresses the effects of ethanol withdrawal on the acoustic startle response in rats. Biological psychiatry, 2000, May-15, Volume: 47, Issue:10 Topics: Animals; Antihypertensive Agents; Auditory Perception; Disease Models, Animal; Ethanol; Imidazoles;	2000

moxonidine and Drug Withdrawal Symptoms