moxifloxacin has been researched along with Long QT Syndrome in 140 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 26 (18.57) | 29.6817 |
| 2010's | 81 (57.86) | 24.3611 |
| 2020's | 33 (23.57) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Chen, S; Ding, CZ; Franzblau, SG; Guo, F; Huang, Z; Li, L; Li, Y; Luo, W; Shen, L; Tang, D; Wang, B; Xu, D; Yang, M; Zhu, Y | 1 |
| Li, G; Li, H; Li, M; Liao, H; Nie, J; Wang, F; Wang, L; Wang, P; Xu, L; Yang, L; Yang, Z | 1 |
| Koesoemoprodjo, W; Kusmiati, T; Luthfah, N; Mertaniasih, NM; Putranto, JNE; Sari, AP; Soedarsono, S; Suprapti, B | 1 |
| Camm, AJ; Cole, ST; Graff, C; Kanters, JK; Pimenta, D; Taubel, J | 1 |
| Bastogne, T; Champéroux, P; Fares, R; Le Guennec, JY; Richard, S; Thireau, J | 1 |
| Gao, J; Gao, M; Li, L; Liu, F; Liu, Y; Pang, Y; Shu, W; Sun, Y; Xie, L; Zhang, L | 1 |
| Goto, A; Ikeda, N; Izumi-Nakaseko, H; Kambayashi, R; Kumagai, Y; Matsuda, K; Matsumoto, A; Oikawa, I; Sugiyama, A; Takei, Y | 1 |
| Baublits, J; Chandra, FA; Chui, RW; Engwall, MJ; Jones, ZW; Vargas, HM; Wahlstrom, J | 1 |
| Bjursell, M; Dota, C; Gottfridsson, C; Johansson, S; Källgren, C; Kӧrnicke, T; Parkinson, J; Perl, S; Rekić, D | 1 |
| Franklin, H; Israel, RJ; Lee, J; Lester, R; Lowe, ER; O'Reilly, T; Slatkin, NE | 1 |
| Bond, J; Brooks, L; Chen, YC; Dolton, M; Langenhorst, J; Li, C; Lien, YTK; Malhi, V; Perez-Moreno, P; Yoshida, K; Yu, J | 1 |
| Bailie, MB; Holdsworth, DL; Lauver, DA; Leishman, DJ; Roche, BM | 1 |
| Darpo, B; Tanaka, SK; Tzanis, E; Xue, H | 1 |
| Anyfantakis, D; Makrakis, G | 1 |
| Cole, ST; Djumanov, D; Ferber, G; Fernandes, S; Prasad, K; Rosano, G; Sugiyama, A; Täubel, J; Van Langenhoven, L; Wibberley, H | 1 |
| Abbas, R; Bachinsky, M; Chappell, PB; Crownover, PH; Damle, B; LaBadie, RR; Riley, S | 1 |
| Flanagan, S; Goodman, DB; Jandourek, A; O'Reilly, T; Sandison, T | 1 |
| Fujio, Y; Hamatani, T; Kaji, Y; Kakuyama, H; Kawai, H; Noda, N; Takagaki, T; Yodo, Y | 1 |
| Aghasafari, P; Bekker, S; Clancy, CE; Dawson, JRD; DeMarco, KR; Jeng, MT; Noskov, SY; Vorobyov, I; Yang, PC; Yarov-Yarovoy, V | 1 |
| Kobayashi, F; Mendell, J; Shimizu, T | 1 |
| Calisti, F; Comandini, A; Del Vecchio, A; Dragone, P; Leuratti, C; Picollo, R; Radicioni, M; Rosignoli, MT; Tellone, V | 1 |
| Ilic, K; Martin, P; Song, I; Wu, J | 1 |
| Bolze, S; Dubourg, J; Felices, M; Fouqueray, P; Perrimond-Dauchy, S; Voiriot, P | 1 |
| Jordaan, P; Kolly, C; Lefèvre, G; Legangneux, E; Neumann, U; Pezous, N; Ufer, M; Vormfelde, SV | 1 |
| He, YC; Huang, JH; Li, LJ; Li, YF; Liang, LY; Wang, K; Xu, FY; Yang, J; Zheng, QS | 1 |
| Chen, J; Huang, DP; Tsong, Y | 1 |
| Carter, LP; Chen, D; Lee, L; Swearingen, D; Zomorodi, K | 1 |
| Ammer, N; Demmel, V; Kelepouris, N; Lissy, M; Ostrow, V; Sachse, R | 1 |
| El-Amin, W; Everitt, D; Li, M; Makhene, MK; Nedelman, J; Osborn, B; Saviolakis, GA; Yang, TJ | 1 |
| Ahmed, GF; Dota, CD; Ghiorghiu, D; Goldwater, R; Li, Y; Mellemgaard, A; Sahota, T; Verheijen, RB; Vik, T; Walker, S; Yan, W | 1 |
| Kumagai, Y; Ohwada, S; Orihashi, Y | 1 |
| Isaacs, R; Maloney, K; Morrison, R; O'Donnell, J; Steidler, M | 1 |
| Boinpally, R; Borbridge, L; Butler, M; McGeeney, D; McNamee, B; Periclou, A; Yao, L | 1 |
| Baublits, J; Chandra, FA; Chui, RW; Engwall, MJ; Jones, ZW; Vargas, HM | 1 |
| Caltabiano, S; Cobitz, AR; Collins, J; Morgan, L; Ravindranath, R; Serbest, G; Smith, DA | 1 |
| Castagné, V; Goineau, S | 1 |
| Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T | 1 |
| Erichsen, L; Grundemar, L; Malmberg, A; Olsson, H; Petri, N | 1 |
| He, YC; Huang, JH; Li, LJ; Liang, LY; Wang, K; Xu, FY; Xu, L; Yang, J; Yin, F; Zheng, QS | 1 |
| Dunzo, E; Fan, L; Heber, W; Hussaini, A; Iwamoto, M; Khalilieh, SG; Liu, R; Triantafyllou, I; Yee, KL | 1 |
| Berg, A; Hanna, D; Hatley, O; Hermann, D; Patel, N; Polak, S; Romero, K; Wisniowska, B | 1 |
| Dixit, A; Jones, S; Karandikar, MV; Nakamura, MM | 1 |
| Ali, Z; Ismail, M; Khan, F; Khan, Q | 1 |
| Chen, J; Dang, Q; Huang, DP; Tsong, Y | 1 |
| Brandquist, C; Chakravarthy, M; Gutierrez, M; Liu, C; Liu, F; Mahon, C; McCrea, J; Mostoller, K; Panebianco, D; Stoch, SA; Zajic, S | 1 |
| Blinova, K; Daluwatte, C; Patel, D; Schocken, D; Strauss, DG; Vicente, J; Wu, JC | 1 |
| Del Parigi, A; Everitt, D; Li, H; Li, M; Mendel, C; Nedelman, JR; Salinger, DH | 1 |
| Benson, C; Brown, R; Couderc, JP; Darpo, B; Dota, C; Ferber, G; Ferry, J; Jarugula, V; Keirns, J; Ortemann-Renon, C; Pham, T; Riley, S; Sarapa, N; Ticktin, M; Zareba, W | 1 |
| Gan, J; Gould, E; Lou, Y; Patel, P; Peppercorn, A; Piscitelli, SC; Weller, S | 1 |
| Bouchard, A; Carr, DB; Hamilton, DA; Lacouture, PG; Lang, E; Madden, D; McDonnell Moorehead, T; Sprenger, CR; Wright, C | 1 |
| Brand, T; Breithaupt-Groegler, K; Broedl, UC; Macha, S; Ring, A; Simons, G; Walter, B; Woerle, HJ | 1 |
| Batchvarov, V; Camm, AJ; Ferber, G; Lorch, U; Savelieva, I; Taubel, J | 1 |
| Cutler, DL; Lin, WH; Tendolkar, A; Troyer, MD; Wang, Z; Xuan, F | 1 |
| Bellibas, SE; Green, CL; Krucoff, MW; Lambe, L; Prats, J; Whellan, DJ; Wijngaard, P | 1 |
| Kawai, T; Miura, M; Murakami, K; Nogawa, H; Ogawa, T; Yajima, M | 1 |
| Fujita, T; Hashimoto, H; Kumagai, Y; Nakamura, Y; Sugiyama, A | 1 |
| Breitschaft, A; Darstein, C; Hu, K; Hudson, M; Jordaan, P; Ligueros-Saylan, M; Shah, R; Song, D | 1 |
| Allen, N; Etheridge, SP; Lux, RL; Saarel, EV; Sower, CT; Tristani-Firouzi, M | 1 |
| Aluri, J; Darpo, B; Fan, J; Martinez, G; Ren, M; Shumaker, RC; Zhou, M | 1 |
| de Kam, PJ; Lillin, O; Post, T; Thomsen, T; van Kuijk, J | 1 |
| Dingemanse, J; Lindegger, N; Reseski, K; Sidharta, PN | 1 |
| Ferber, G; Täubel, J; Wang, D | 1 |
| Caillaud, MA; Donazzolo, Y; Latreille, M; Mocaer, E; Seguin, L | 1 |
| Brealey, N; Kelleher, D; Mehta, R; Preece, A; Tombs, L | 1 |
| Fossa, AA; Martin, P; Purkayastha, J; Robinson, A; Zhou, M | 1 |
| Brossard, P; Darpo, B; Dingemanse, J; Hoch, M; Stoltz, R; Zhou, M | 1 |
| Bruderer, S; Darpo, B; Dingemanse, J; Hoch, M; Kaufmann, P; Remenova, T; Stoltz, R; Zhou, M | 1 |
| Arya, N; Barbour, AM; Fossler, MJ; Glaser, R; Magee, M; Patel, BR; Shaddinger, B; Tao, W; Tombs, L | 1 |
| Chanter, D; Chen, Q; Hu, CY; Jia, JY; Liu, GY; Liu, Y; Liu, YM; Mendzelevski, B; Pu, HH; Wang, W; Weng, O; Yu, C | 1 |
| Harris, S; Kleiman, R; Kumagai, Y; Morganroth, J; Shah, R; Stockbridge, N; Thorn, M; Wang, Y | 1 |
| Cools, F; Danhof, M; Gallacher, DJ; Gotta, V; Morissette, P; Sannajust, F; van Ammel, K; van der Graaf, PH; Visser, SA | 1 |
| Ferry, J; Hussein, Z; Laurenza, A; Patten, A; Williams, B; Yang, H | 1 |
| Blinova, K; Chan, D; Crumb, WJ; Erato, C; Florian, J; Guo, P; Hong, M; Johannesen, L; Lin, J; Mason, JW; Mutlib, A; Sanabria, C; Stockbridge, N; Stohlman, J; Strauss, DG; Ugander, M; Vicente, J; Waite-Labott, K; Wang, J | 1 |
| Denis, E; Duvauchelle, T; Maison-Blanche, P; Robert, P; Shah, RR | 1 |
| Ferber, G; Lorch, U; Täubel, J | 1 |
| Allison, M; Aslanis, V; Brendani, B; Juan, A; Legangneux, E; Mooney, L; Perry, R; Pezous, N; Shakeri-Nejad, K; Veldandi, UK | 1 |
| Danhof, M; de Witte, WE; Della Pasqua, O; Dubois, VF; Visser, SA | 1 |
| Badilini, F; Damle, A; Kadam, P; Karnad, DR; Kothari, S; Panicker, GK | 1 |
| Falcão, A; Homery, MC; l'Hostis, P; Nunes, T; Patat, A; Pinto, R; Rocha, JF; Soares-da-Silva, P | 1 |
| Buchanan, AM; Chen, S; Ford, SL; Gould, E; Lou, Y; Margolis, D; Patel, P; Spreen, WR | 1 |
| Chen, J; Crissey, A; Kulmatycki, K; Majumdar, T; Meyers, CD; Movva, A; Neelakantham, S; Noe, A; Salunke, A | 1 |
| Casarotto, E; Danhof, M; Della Pasqua, O; Dubois, VF | 1 |
| Cardillo Marricco, N; DeGroot, B; Dunnington, K; Gendrano, IN; George, L; Glasgow, XS; Johnson-Levonas, AO; Kauh, E; Swearingen, D; Tatosian, DA | 1 |
| Darpo, B; Dumont, E; Hossain, M; Tiffany, C; Zhou, M | 1 |
| Dixon, R; Job, S; Lorch, U; Maltby, K; Oliver, R; Taubel, J; Tompson, D; Wright, JG | 1 |
| Mortara, DW | 1 |
| Bloomfield, DM; Ghosh, K; Gottesdiener, K; Guitierrez, MJ; Hickey, LA; Hreniuk, D; Kost, JT; Wagner, JA | 1 |
| Clax, P; Damle, B; Fosser, C; Glue, P; Ito, K; Tran, A; Uderman, H | 1 |
| Agin, M; Darpo, B; Duczynski, G; Fosser, C; Wicker, P | 1 |
| Balez, S; Dumortier, T; Sechaud, R | 1 |
| Badshah, A; Cotant, JF; Halabi, AR; Janjua, M; Younas, F | 1 |
| Bois, P; Dilly, S; Ducroq, J; Faivre, JF; Guilbot, S; Laemmel, E; Le Grand, M; Moha ou Maati, H; Pons-Himbert, C; Stücker, O | 1 |
| Atiee, GJ; Crumley, T; Ebel, D; Johnson-Levonas, AO; Lai, E; Luo, WL; Royalty, J; Wagner, J | 1 |
| Hill, LA; Hoel, G; Lepor, H; Morganroth, J; Volinn, W | 1 |
| Gandelman, K; Malhotra, B; Sachse, R; Wood, N | 1 |
| Couderc, JP; Garnett, C; Handzel, R; Li, M; McNitt, S; Polonsky, S; Xia, X; Zareba, W | 1 |
| Couderc, JP; McNitt, S; Moss, AJ; Peterson, DR; Polonsky, S; Xia, X; Zareba, W; Zhao, H | 1 |
| Eusebio, J; Farhoumand, AD; Trombert, V | 1 |
| Cristea, L; Farha, R; Jordan, P; Kolis, S; Lee, LS; Salgo, M; Zhang, X | 1 |
| Ferber, G; Greiter-Wilke, A; Holzgrefe, HH; Meyer, O; Morrison, R; Singer, T | 1 |
| Jochelson, P; Kittrelle, JP; Ludington, E; Mansbach, RS; Rogowski, R | 1 |
| Couderc, JP; Darpo, B; Davis, JD; Fossa, AA; Langdon, G; Wallis, R; Wilson, F; Zhou, M | 1 |
| Andersen, MP; Graff, C; Højer, AM; Kallio, A; Kanters, JK; Matz, J; Struijk, JJ; Toft, E; Vainio, PJ | 1 |
| Arezina, R; Camm, AJ; Harada, T; Lorch, U; Naseem, A; Onel, E; Taubel, J; Wang, D | 1 |
| Bentley, D; Jordan, P; Ruf, T; Russell-Yarde, F; Sturm, S | 1 |
| George, S; Gussak, I; Ipe, D; Rodriguez, I; Sager, PT; Vajdic, B | 1 |
| Arezina, R; Camm, AJ; Lorch, U; Naseem, A; Taubel, J; Wang, D | 1 |
| del Corral, A; Dutreix, C; Harrell, R; Huntsman-Labed, A; Lorenzo, S; Morganroth, J; Wang, Y | 1 |
| Andersen, MP; Graff, C; Kanters, JK; Struijk, JJ; Toft, E; Tyl, B | 1 |
| Borland, J; Chen, S; Fujiwara, T; Lou, Y; Min, SS; Peppercorn, A; Piscitelli, SC; Song, I | 1 |
| George, S; Green, CL; Gussak, I; Kligfield, P; Krucoff, MW; Sager, P; Vajdic, B | 1 |
| de Kam, PJ; Peeters, P; Smeets, J; Thomsen, T; van Kuijk, J | 1 |
| Arvis, P; Fritsch, A; Haverkamp, W; Kruesmann, F; van Veenhuyzen, D | 1 |
| Cirincione, B; Darpö, B; Han, J; Huang, W; MacConell, L; Malloy, J; Mitchell, M; Porter, L; Sager, P; Schulteis, C; Shen, L | 1 |
| Haugen, G; Kellerman, DJ; Kori, S; Voloshko, P | 1 |
| Banken, L; Hahn, M; Hofmann, C; Martin-Facklam, M; Nagel, S; Swearingen, D | 1 |
| Ayache, JA; Chang, I; Dresser, MJ; Dufek, MB; Ezzet, F; Graham, RA; Jin, JY; Low, JA; Wang, B; Zerivitz, K | 1 |
| de Koning, P; Goldwater, R; Kaibara, A; Keirns, JJ; Kowalski, DL; Lee, JH; Malik, M; Moy, SS; Mujais, SK; Schaddelee, MP; van Gelderen, EM; Yen, M | 1 |
| Gretler, DD; Hollenbach, SJ; Lambing, JL; Morganroth, J; Sinha, U | 1 |
| Ball, HA; Dar, MM; Heath, EI; Infante, J; Kasubhai, S; Kleha, JF; Lewis, LD; LoRusso, P; Luu, T; Ma, B; Stephenson, J; Suttle, AB; Tan, AR | 1 |
| Chain, AS; Danhof, M; Della Pasqua, O; Dubois, VF; Sturkenboom, MC | 1 |
| Chiba, K; Hagiwara, T; Hashimoto, K; Sugiyama, A; Takahashi, S; Takasuna, K | 1 |
| Beaufils, P; Cabanis, MJ; Extramiana, F; Leenhardt, A; Maison-Blanche, P; Ortemann-Renon, C | 1 |
| Hart, SM; Mittelstadt, SW | 1 |
| Bradley, JA; Cass, JD; Chen, X; Dahm, CM; Engwall, MJ; Kadyszewski, E; Sun, Z; Zhou, J | 1 |
| Cox, CD; Meyerrose, GE; Peeters, MJ; Seifert, CF; Tsikouris, JP | 1 |
| Agin, M; Darpo, B; Gray, P; Jorkasky, DK; Kazierad, DJ; Layton, G; Muirhead, G | 1 |
| Attevelt, NJ; Beekman, JD; Chiba, K; Sugiyama, A; Takahara, A; Thomsen, MB; Vos, MA | 1 |
| Falagas, ME; Rafailidis, PI; Rosmarakis, ES | 1 |
| Amantea, MA; Nickens, DJ; Raber, SR; Reynolds, RR; Sarapa, N | 1 |
| Akyurek, O; Altin, T; Guldal, M; Karaoguz, R; Ongun Ozdemir, A; Ozcan, O; Turhan, S | 1 |
| Daoust, A; Hulhoven, R; Letiexhe, M; Meeus, MA; Rosillon, D; Stockis, A | 1 |
| Couderc, JP; Hyrien, O; McNitt, S; Moss, AJ; Polonsky, S; Vaglio, M; Xia, X; Zareba, W | 1 |
| Roger, J; Stephens, K; Stylianou, A | 1 |
| Chen, WJ; Tsong, Y; Zhong, J | 1 |
| Shen, M; Tsong, Y; Zhang, J; Zhong, J | 1 |
| Anderson, ME; Mazur, A; Roden, DM; Yang, T | 1 |
| Cox, BF; Gintant, GA; Limberis, JT; McDermott, JS; Wegner, CD | 1 |
3 review(s) available for moxifloxacin and Long QT Syndrome
| Article | Year |
|---|---|
Moxifloxacin-induced QT interval prolongation and torsades de pointes: a narrative review.
Topics: Aged; Anti-Bacterial Agents; Electrocardiography; Fluoroquinolones; Humans; Long QT Syndrome; Moxifloxacin; Risk Assessment; Risk Factors; Torsades de Pointes | 2018 |
Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis.
Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluoroquinolones; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenethylamines; Potassium Channel Blockers; Reproducibility of Results; Sotalol; Sulfonamides; Telemetry; Translational Research, Biomedical | 2015 |
Arrhythmias associated with fluoroquinolone therapy.
Topics: Anti-Bacterial Agents; Arrhythmias, Cardiac; Aza Compounds; Drug Interactions; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Moxifloxacin; Quinolines; Risk Factors; Torsades de Pointes | 2007 |
93 trial(s) available for moxifloxacin and Long QT Syndrome
| Article | Year |
|---|---|
Four-Way Crossover Phase 1 Thorough QT Study to Assess Cardiac Safety of Domperidone and Consideration for Design and Conduct of QT/QTc Study in China.
Topics: Domperidone; Heart; Humans; Long QT Syndrome; Moxifloxacin | 2022 |
Effect of hyperglycaemia in combination with moxifloxacin on cardiac repolarization in male and female patients with type I diabetes.
Topics: Blood Glucose; Cross-Over Studies; Death, Sudden, Cardiac; Diabetes Mellitus, Type 1; Double-Blind Method; Female; Heart Rate; Humans; Hyperglycemia; Insulins; Long QT Syndrome; Male; Moxifloxacin | 2022 |
Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects.
Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Fluoroquinolones; Healthy Volunteers; Heart Rate; Humans; Integrin alpha4; Japan; Long QT Syndrome; Moxifloxacin; Phenylalanine; Quinazolinones | 2022 |
Verinurad does not prolong QTc interval: a thorough QT study using concentration-QTc modelling.
Topics: Allopurinol; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Heart Rate; Humans; Long QT Syndrome; Moxifloxacin; Uric Acid | 2023 |
A Randomized, Double-Blind, Parallel Design Thorough QT Study With a Nested Crossover to Compare the Cardiac Safety of Amiselimod With Placebo and Positive Control in Healthy Volunteers.
Topics: Adult; Double-Blind Method; Electrocardiography; Fluoroquinolones; Healthy Volunteers; Humans; Long QT Syndrome; Moxifloxacin | 2023 |
Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects.
Topics: Adult; Anti-Bacterial Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Healthy Volunteers; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Tetracyclines | 2019 |
Effects of the Fluoroquinolones Moxifloxacin and Levofloxacin on the QT Subintervals: Sex Differences in Ventricular Repolarization.
Topics: Action Potentials; Adult; Algorithms; Anti-Bacterial Agents; Calcium Channels; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Gonadal Steroid Hormones; Healthy Volunteers; Heart; Humans; Levofloxacin; Long QT Syndrome; Male; Moxifloxacin; Potassium Channels; Retrospective Studies; Sex Characteristics | 2020 |
A Thorough QT Study to Evaluate the Effects of a Supratherapeutic Dose of Sertraline on Cardiac Repolarization in Healthy Subjects.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors; Young Adult | 2020 |
Lack of Effect of Rezafungin on QT/QTc Interval in Healthy Subjects.
Topics: Adult; Antifungal Agents; Dose-Response Relationship, Drug; Double-Blind Method; Echinocandins; Electrocardiography; Female; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Young Adult | 2020 |
Thorough QT/QTc Study Shows That a Novel 5-HT
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Arrhythmias, Cardiac; Asian People; Benzamides; Case-Control Studies; Cisapride; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Humans; Indoles; Irritable Bowel Syndrome; Long QT Syndrome; Male; Morpholines; Moxifloxacin; Piperidines; Placebos; Serotonin 5-HT4 Receptor Agonists; Serotonin Receptor Agonists | 2020 |
Randomized, Double-Blind, Single-Dose, Placebo-Controlled Crossover Study to Evaluate the Effects of Esaxerenone on QTc Interval in Healthy Subjects.
Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Mineralocorticoid Receptor Antagonists; Moxifloxacin; Pyrroles; Sulfones; Young Adult | 2020 |
Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Antidepressive Agents, Second-Generation; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Volunteers; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Pharmaceutical Solutions; Trazodone; Young Adult | 2020 |
Evaluation of the Effect of Maribavir on Cardiac Repolarization in Healthy Participants: Thorough QT/QTc Study.
Topics: Administration, Oral; Adolescent; Adult; Antiviral Agents; Benzimidazoles; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Dysgeusia; Electrocardiography; Female; Healthy Volunteers; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Ribonucleosides; Young Adult | 2020 |
Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus.
Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Humans; Hypoglycemic Agents; Long QT Syndrome; Male; Moxifloxacin; Triazines | 2020 |
Relationship between antofloxacin concentration and QT prolongation and estimation of the possible false-positive rate.
Topics: Adult; Anti-Bacterial Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; False Positive Reactions; Female; Healthy Volunteers; Heart Rate; Humans; Long QT Syndrome; Male; Models, Statistical; Moxifloxacin; Ofloxacin; Young Adult | 2020 |
A Randomized, Double-Blind, Placebo- and Positive-Controlled, 4-Period Crossover Study of the Effects of Solriamfetol on QTcF Intervals in Healthy Participants.
Topics: Adrenergic Uptake Inhibitors; Adult; Carbamates; Cross-Over Studies; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Phenylalanine; Young Adult | 2021 |
Thorough QT/QTc Study Evaluating the Effect of Macimorelin on Cardiac Safety Parameters in Healthy Participants.
Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Heart Rate; Humans; Indoles; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Tryptophan; Young Adult | 2021 |
Phase 1 Study of the Effects of the Tuberculosis Treatment Pretomanid, Alone and in Combination With Moxifloxacin, on the QTc Interval in Healthy Volunteers.
Topics: Adolescent; Adult; Antitubercular Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Nitroimidazoles; Young Adult | 2021 |
A Randomized, Double-Blind, Placebo- and Positive-Controlled, Three-Way Crossover Study in Healthy Participants to Investigate the Effect of Savolitinib on the QTc Interval.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Protein Kinase Inhibitors; Pyrazines; Triazines | 2021 |
A randomized, double-blind, placebo- and positive-controlled crossover study of the effects of durlobactam on cardiac repolarization in healthy subjects.
Topics: Administration, Oral; Adult; Azabicyclo Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Healthy Volunteers; Heart Rate; Humans; Infusions, Intravenous; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Young Adult | 2021 |
A Single Supratherapeutic Dose of Atogepant Does Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized, Single-Dose, Phase 1 Crossover Trial.
Topics: Adolescent; Adult; Area Under Curve; Calcitonin Gene-Related Peptide Receptor Antagonists; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Moxifloxacin; Piperidines; Pyridines; Pyrroles; Spiro Compounds; Young Adult | 2021 |
A Randomized, Placebo- and Positive-Controlled, Single-Dose, Crossover Thorough QT/QTc Study Assessing the Effect of Daprodustat on Cardiac Repolarization in Healthy Subjects.
Topics: Adolescent; Adult; Barbiturates; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Female; Fluoroquinolones; Glycine; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Prolyl-Hydroxylase Inhibitors; Single-Blind Method; Young Adult | 2017 |
Effect of Degarelix, a Gonadotropin-Releasing Hormone Receptor Antagonist for the Treatment of Prostate Cancer, on Cardiac Repolarisation in a Randomised, Placebo and Active Comparator Controlled Thorough QT/QTc Trial in Healthy Men.
Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Electrocardiography; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Oligopeptides; Receptors, LHRH; Young Adult | 2017 |
A Randomized Trial to Assess the Effect of Doravirine on the QTc Interval Using a Single Supratherapeutic Dose in Healthy Adult Volunteers.
Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Pyridones; Reverse Transcriptase Inhibitors; Triazoles; Young Adult | 2017 |
Thorough QTc Evaluation and the Safety of Supratherapeutic Doses of Odanacatib in Healthy Subjects.
Topics: Adult; Biphenyl Compounds; Cathepsin K; Dose-Response Relationship, Drug; Double-Blind Method; Drug Dosage Calculations; Electrocardiography, Ambulatory; Female; Healthy Volunteers; Heart Rate; Humans; Long QT Syndrome; Male; Margins of Excision; Moxifloxacin; Young Adult | 2019 |
Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs.
Topics: Action Potentials; Adult; Cardiotoxicity; Cell Differentiation; Cells, Cultured; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Induced Pluripotent Stem Cells; Long QT Syndrome; Male; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Primary Cell Culture; Sulfonamides; Toxicity Tests | 2019 |
Long-Term Effects on QT Prolongation of Pretomanid Alone and in Combinations in Patients with Tuberculosis.
Topics: Antitubercular Agents; Computer Simulation; Diarylquinolines; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Heart Rate; Humans; Linezolid; Long QT Syndrome; Models, Statistical; Moxifloxacin; Mycobacterium tuberculosis; Nitroimidazoles; Pyrazinamide; Tuberculosis, Multidrug-Resistant | 2019 |
Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study.
Topics: Arrhythmias, Cardiac; Biomarkers; Cetirizine; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart Conduction System; Heart Rate; Humans; Indoles; Ion Channels; Long QT Syndrome; Male; Moxifloxacin; Ondansetron; Phenethylamines; Quinine; Quinolizines; Risk Assessment; Sulfonamides | 2020 |
Effect of intravenous zanamivir on cardiac repolarization.
Topics: Administration, Oral; Adult; Antiviral Agents; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Infusions, Intravenous; Long QT Syndrome; Male; Moxifloxacin; Quinolines; Time Factors; Young Adult; Zanamivir | 2013 |
Effects of injectable HPβCD-diclofenac on the human delayed rectifier potassium channel current in vitro and on proarrhythmic QTc in vivo.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aza Compounds; beta-Cyclodextrins; Cross-Over Studies; Diclofenac; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; HEK293 Cells; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Quinolines; Young Adult | 2013 |
The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study.
Topics: Action Potentials; Adolescent; Adult; Benzhydryl Compounds; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Germany; Glucosides; Heart Conduction System; Heart Rate; Humans; Hypoglycemic Agents; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Risk Assessment; Risk Factors; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Time Factors; Young Adult | 2013 |
Thorough QT study of the effect of oral moxifloxacin on QTc interval in the fed and fasted state in healthy Japanese and Caucasian subjects.
Topics: Administration, Oral; Adult; Asian People; Eating; Electrocardiography; Fasting; Female; Fluoroquinolones; Healthy Volunteers; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; White People; Young Adult | 2014 |
Preladenant, a selective adenosine A₂A receptor antagonist, is not associated with QT/QTc prolongation.
Topics: Adenosine A2 Receptor Antagonists; Adolescent; Adult; Antiparkinson Agents; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Pyrimidines; Quinolines; Triazoles; Young Adult | 2013 |
Electrocardiographic safety of cangrelor, a new intravenous antiplatelet agent: a randomized, double-blind, placebo- and moxifloxacin-controlled thorough QT study.
Topics: Adenosine Monophosphate; Adolescent; Adult; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Follow-Up Studies; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Quinolines; Time Factors; Young Adult | 2013 |
QT/QTc study conducted in Japanese adult healthy subjects: a novel xanthine oxidase inhibitor topiroxostat was not associated with QT prolongation.
Topics: Adult; Asian People; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Nitriles; Pyridines; Xanthine Oxidase; Young Adult | 2014 |
Effects of Subcutaneous Pasireotide on Cardiac Repolarization in Healthy Volunteers: a Single‐Center, Phase I, Randomized, Four‐Way Crossover Study.
Topics: Adolescent; Adult; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Female; Fluoroquinolones; Heart; Heart Rate; Humans; Injections, Subcutaneous; Long QT Syndrome; Male; Middle Aged; Models, Statistical; Moxifloxacin; Quinolines; Sample Size; Somatostatin; Young Adult | 2014 |
Effect of lenvatinib (E7080) on the QTc interval: results from a thorough QT study in healthy volunteers.
Topics: Adult; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenylurea Compounds; Quinolines; Young Adult | 2014 |
The effect of therapeutic and supratherapeutic oral doses of nomegestrol acetate (NOMAC)/17β-estradiol (E2) on QTcF intervals in healthy women: results from a randomized, double-blind, placebo- and positive-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Contraceptives, Oral, Combined; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Estradiol; Female; Fluoroquinolones; Humans; Long QT Syndrome; Megestrol; Middle Aged; Moxifloxacin; Norpregnadienes; Time Factors; Young Adult | 2014 |
Macitentan, a dual endothelin receptor antagonist for the treatment of pulmonary arterial hypertension, does not affect cardiac repolarization in healthy subjects.
Topics: Adult; Arrhythmias, Cardiac; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Endothelin Receptor Antagonists; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Pyrimidines; Sulfonamides; Young Adult | 2014 |
Concentration-effect modeling based on change from baseline to assess the prolonging effect of drugs on QTc together with an estimate of the circadian time course.
Topics: Analgesics; Anti-Bacterial Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Fluoroquinolones; Food-Drug Interactions; Humans; Long QT Syndrome; Models, Biological; Morpholines; Moxifloxacin; Pyrazoles | 2014 |
Evaluation of the effects of therapeutic and supratherapeutic doses of agomelatine on the QT/QTc interval: a phase I, randomized, double-blind, placebo-controlled and positive-controlled, crossover thorough QT/QTc study conducted in healthy volunteers.
Topics: Acetamides; Adolescent; Adult; Antidepressive Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Moxifloxacin; Young Adult | 2014 |
A randomized, placebo- and moxifloxacin-controlled thorough QT study of umeclidinium monotherapy and umeclidinium/vilanterol combination in healthy subjects.
Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adult; Benzyl Alcohols; Chlorobenzenes; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Dry Powder Inhalers; Female; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Muscarinic Antagonists; Quinuclidines; Single-Blind Method; Young Adult | 2014 |
Use of ECG restitution (beat-to-beat QT-TQ interval analysis) to assess arrhythmogenic risk of QTc prolongation with guanfacine.
Topics: Adrenergic alpha-2 Receptor Agonists; Arrhythmias, Cardiac; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography, Ambulatory; Female; Fluoroquinolones; Guanfacine; Humans; Long QT Syndrome; Male; Moxifloxacin; Reference Values; Retrospective Studies; Risk Assessment | 2014 |
Effect of ponesimod, a selective S1P1 receptor modulator, on the QT interval in healthy individuals.
Topics: Action Potentials; Adolescent; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Receptors, Lysosphingolipid; Risk Assessment; Sphingosine-1-Phosphate Receptors; Thiazoles; Time Factors; Young Adult | 2015 |
A thorough QT study in the context of an uptitration regimen with selexipag, a selective oral prostacyclin receptor agonist.
Topics: Acetamides; Administration, Oral; Adolescent; Adult; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Placebos; Pyrazines; Receptors, Epoprostenol; Receptors, Prostaglandin; Young Adult | 2015 |
Utility of concentration-effect modeling and simulation in a thorough QT study of losmapimod.
Topics: Adult; Aged; Cross-Over Studies; Cyclopropanes; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Models, Biological; Moxifloxacin; Protein Kinase Inhibitors; Pyridines; Topoisomerase II Inhibitors; Young Adult | 2015 |
Orally administered moxifloxacin prolongs QTc in healthy Chinese volunteers: a randomized, single-blind, crossover study.
Topics: Administration, Oral; Adolescent; Adult; Asian People; Cross-Over Studies; Dose-Response Relationship, Drug; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Single-Blind Method; Topoisomerase II Inhibitors; Young Adult | 2015 |
Moxifloxacin-induced QTc interval prolongations in healthy male Japanese and Caucasian volunteers: a direct comparison in a thorough QT study.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Asian People; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Fluoroquinolones; Healthy Volunteers; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Prospective Studies; White People | 2015 |
Lack of effect of perampanel on QT interval duration: Results from a thorough QT analysis and pooled partial seizure Phase III clinical trials.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrocardiography; Epilepsies, Partial; Female; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Nitriles; Pyridones; Reference Values; Young Adult | 2015 |
Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial.
Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Drug Therapy, Combination; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Moxifloxacin; Phenethylamines; Prospective Studies; Sodium Channel Blockers; Sulfonamides; Young Adult | 2016 |
Establishing assay sensitivity in QT studies: experience with the use of moxifloxacin in an early phase clinical pharmacology study and comparison with its effect in a thorough QT study.
Topics: Adolescent; Adult; Cost-Benefit Analysis; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Feasibility Studies; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Sensitivity and Specificity; Young Adult | 2015 |
Effects of Therapeutic and Supratherapeutic Doses of Siponimod (BAF312) on Cardiac Repolarization in Healthy Subjects.
Topics: Adolescent; Adult; Azetidines; Benzyl Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heart; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Young Adult | 2015 |
Detecting moxifloxacin-induced QTc prolongation in thorough QT and early clinical phase studies using a highly automated ECG analysis approach.
Topics: Automation; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Moxifloxacin | 2016 |
Evaluation of opicapone on cardiac repolarization in a thorough QT/QTc study.
Topics: Action Potentials; Adolescent; Adult; Catechol O-Methyltransferase Inhibitors; Cross-Over Studies; Double-Blind Method; Electrocardiography, Ambulatory; Female; Fluoroquinolones; France; Healthy Volunteers; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Oxadiazoles; Risk Assessment; Time Factors; Young Adult | 2015 |
Effect of Cabotegravir on Cardiac Repolarization in Healthy Subjects.
Topics: Adolescent; Adult; Anti-HIV Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Pyridones; Young Adult | 2016 |
Effect of Pradigastat, a Diacylglycerol Acyltransferase 1 Inhibitor, on the QTcF Interval in Humans.
Topics: Acetates; Adolescent; Adult; Aminopyridines; Body Mass Index; Diacylglycerol O-Acyltransferase; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Enzyme Inhibitors; Fluoroquinolones; Healthy Volunteers; Heart Rate; Humans; Hyperlipoproteinemia Type I; Long QT Syndrome; Male; Moxifloxacin; Young Adult | 2016 |
A Thorough QTc Study Confirms Early Pharmacokinetics/QTc Modeling: A Supratherapeutic Dose of Omarigliptin, a Once-Weekly DPP-4 Inhibitor, Does Not Prolong the QTc Interval.
Topics: Adolescent; Adult; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heterocyclic Compounds, 2-Ring; Humans; Hypoglycemic Agents; Long QT Syndrome; Male; Middle Aged; Models, Biological; Moxifloxacin; Pyrans; Young Adult | 2016 |
A Phase I, Randomized, Double-Blinded, Placebo- and Moxifloxacin-Controlled, Four-Period Crossover Study To Evaluate the Effect of Gepotidacin on Cardiac Conduction as Assessed by 12-Lead Electrocardiogram in Healthy Volunteers.
Topics: Acenaphthenes; Adolescent; Adult; Anti-Bacterial Agents; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart Rate; Heterocyclic Compounds, 3-Ring; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Young Adult | 2017 |
Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Anti-Arrhythmia Agents; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Lamotrigine; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Treatment Outcome; Triazines | 2008 |
The effect of moxifloxacin on QTc and implications for the design of thorough QT studies.
Topics: Adult; Anti-Infective Agents; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Moxifloxacin; Pilot Projects; Quinolines; Research Design | 2008 |
Effects of standard and supratherapeutic doses of nelfinavir on cardiac repolarization: a thorough QT study.
Topics: Adult; Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; Aza Compounds; Cross-Over Studies; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Fluoroquinolones; Heart Rate; HIV Protease Inhibitors; Humans; Long QT Syndrome; Middle Aged; Moxifloxacin; Nelfinavir; Polymorphism, Genetic; Quinolines | 2009 |
Deferasirox does not induce QT/QTc-prolongation in healthy subjects.
Topics: Adolescent; Adult; Aged; Area Under Curve; Aza Compounds; Benzoates; Deferasirox; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Humans; Iron Chelating Agents; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Triazoles; Young Adult | 2009 |
Single therapeutic and supratherapeutic doses of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, do not prolong the QTcF interval in healthy volunteers.
Topics: Adolescent; Adult; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Humans; Indoles; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Receptors, Immunologic; Receptors, Prostaglandin; Young Adult | 2010 |
Effects of the selective alpha 1a-adrenoceptor antagonist silodosin on ECGs of healthy men in a randomized, double-blind, placebo- and moxifloxacin-controlled study.
Topics: Adolescent; Adrenergic alpha-1 Receptor Antagonists; Adult; Aza Compounds; Double-Blind Method; Electrocardiography; Fluoroquinolones; Heart Rate; Humans; Indoles; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Receptors, Adrenergic, alpha-1; Young Adult | 2010 |
Thorough QT study of the effect of fesoterodine on cardiac repolarization.
Topics: Aza Compounds; Benzhydryl Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Humans; Least-Squares Analysis; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Muscarinic Antagonists; Quinolines; Urinary Bladder, Overactive | 2010 |
T-wave morphology abnormalities in benign, potent, and arrhythmogenic I(kr) inhibition.
Topics: Adult; Anti-Infective Agents; Aza Compounds; DNA; DNA Mutational Analysis; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Follow-Up Studies; Genotype; Heart; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Mutation; Quinolines; Retrospective Studies; Risk Factors | 2011 |
Thorough QT/QTc study of ritonavir-boosted saquinavir following multiple-dose administration of therapeutic and supratherapeutic doses in healthy participants.
Topics: Adolescent; Adult; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Fluoroquinolones; HIV Protease Inhibitors; Humans; Least-Squares Analysis; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Ritonavir; Saquinavir; Torsades de Pointes; Young Adult | 2012 |
A placebo- and active-controlled assessment of 6- and 50-mg oral doxepin on cardiac repolarization in healthy volunteers: a thorough QT evaluation.
Topics: Administration, Oral; Adult; Aza Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Doxepin; Electrocardiography, Ambulatory; Female; Fluoroquinolones; Histamine Antagonists; Humans; Long QT Syndrome; Male; Moxifloxacin; Quinolines; Young Adult | 2011 |
The use of beat-to-beat electrocardiogram analysis to distinguish QT/QTc interval changes caused by moxifloxacin from those caused by vardenafil.
Topics: Anti-Infective Agents; Arrhythmias, Cardiac; Autonomic Nervous System; Aza Compounds; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Heart; Heart Rate; Humans; Imidazoles; Long QT Syndrome; Male; Moxifloxacin; Phosphodiesterase 5 Inhibitors; Piperazines; Placebos; Quinolines; Sulfones; Tachycardia; Triazines; Vardenafil Dihydrochloride | 2011 |
Effect of nalmefene 20 and 80 mg on the corrected QT interval and T-wave morphology: a randomized, double-blind, parallel-group, placebo- and moxifloxacin-controlled, single-centre study.
Topics: Adult; Anti-Infective Agents; Arrhythmias, Cardiac; Aza Compounds; Biomarkers, Pharmacological; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Guidelines as Topic; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Naltrexone; Narcotic Antagonists; Placebos; Prospective Studies; Quinolines; Treatment Outcome; Young Adult | 2011 |
Bupivacaine extended release liposome injection does not prolong QTc interval in a thorough QT/QTc study in healthy volunteers.
Topics: Adult; Anesthetics, Local; Anti-Infective Agents; Aza Compounds; Bupivacaine; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Fluoroquinolones; Humans; Liposomes; Long QT Syndrome; Male; Moxifloxacin; Quinolines | 2012 |
No evidence of QT prolongation with supratherapeutic doses of aleglitazar.
Topics: Adult; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Oxazoles; PPAR alpha; PPAR gamma; Quinolines; Thiophenes; Time Factors; Young Adult | 2012 |
Computerized extraction of electrocardiograms from continuous 12-lead holter recordings reduces measurement variability in a thorough QT study.
Topics: Adult; Algorithms; Anti-Infective Agents; Aza Compounds; Cross-Over Studies; Diagnosis, Computer-Assisted; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Research Design; Young Adult | 2012 |
Repeated supratherapeutic dosing of strontium ranelate over 15 days does not prolong QT(c) interval in healthy volunteers.
Topics: Administration, Oral; Adult; Anti-Infective Agents; Aza Compounds; Bone Density Conservation Agents; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Linear Models; London; Long QT Syndrome; Male; Moxifloxacin; Nonlinear Dynamics; Organometallic Compounds; Patient Safety; Predictive Value of Tests; Quinolines; Risk Assessment; Risk Factors; Thiophenes; Young Adult | 2012 |
Midostaurin does not prolong cardiac repolarization defined in a thorough electrocardiogram trial in healthy volunteers.
Topics: Adolescent; Adult; Antineoplastic Agents; Aza Compounds; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Protein Kinase Inhibitors; Quinolines; Staurosporine; Young Adult | 2012 |
Effects of bilastine on T-wave morphology and the QTc interval: a randomized, double-blind, placebo-controlled, thorough QTc study.
Topics: Adult; Aza Compounds; Benzimidazoles; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Guidelines as Topic; Histamine Antagonists; Humans; Long QT Syndrome; Male; Moxifloxacin; Piperidines; Quinolines; Time Factors; Young Adult | 2012 |
Effect of a single supratherapeutic dose of dolutegravir on cardiac repolarization.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Aza Compounds; Confidence Intervals; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Follow-Up Studies; Heart Conduction System; Heterocyclic Compounds, 3-Ring; HIV Integrase Inhibitors; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Oxazines; Piperazines; Pyridones; Quinolines; Socioeconomic Factors; Young Adult | 2012 |
Detection of QT prolongation using a novel electrocardiographic analysis algorithm applying intelligent automation: prospective blinded evaluation using the Cardiac Safety Research Consortium electrocardiographic database.
Topics: Algorithms; Anti-Infective Agents; Automation; Aza Compounds; Double-Blind Method; Electrocardiography; Fluoroquinolones; Follow-Up Studies; Humans; Long QT Syndrome; Moxifloxacin; Prospective Studies; Quinolines; Reproducibility of Results | 2012 |
Sugammadex is not associated with QT/QTc prolongation: methodology aspects of an intravenous moxifloxacin-controlled thorough QT study.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; gamma-Cyclodextrins; Humans; Injections, Intravenous; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Neuromuscular Agents; Quinolines; Sugammadex | 2012 |
Exenatide at therapeutic and supratherapeutic concentrations does not prolong the QTc interval in healthy subjects.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Exenatide; Female; Fluoroquinolones; Heart Rate; Humans; Hypoglycemic Agents; Infusions, Intravenous; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Peptides; Quinolines; Venoms | 2013 |
Effects of a supratherapeutic dose of investigational orally inhaled dihydroergotamine (MAP0004) on QT interval: a randomized, double-blind, active- and placebo-controlled crossover study in healthy volunteers.
Topics: Administration, Inhalation; Adult; Aza Compounds; Cross-Over Studies; Dihydroergotamine; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Vasoconstrictor Agents; Young Adult | 2012 |
Evaluation of the effects of bitopertin (RG1678) on cardiac repolarization: a thorough corrected QT study in healthy male volunteers.
Topics: Adult; Aza Compounds; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography, Ambulatory; Fluoroquinolones; Follow-Up Studies; Glycine Plasma Membrane Transport Proteins; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Piperazines; Quinolines; Sulfones; Tandem Mass Spectrometry; Young Adult | 2012 |
Daily dosing of vismodegib to steady state does not prolong the QTc interval in healthy volunteers.
Topics: Administration, Oral; Aged; Anilides; Antineoplastic Agents; Aza Compounds; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Female; Fluoroquinolones; France; Heart Rate; Humans; Linear Models; Long QT Syndrome; Middle Aged; Models, Biological; Moxifloxacin; Pyridines; Quinolines; Risk Assessment; Time Factors | 2013 |
Proarrhythmic safety of repeat doses of mirabegron in healthy subjects: a randomized, double-blind, placebo-, and active-controlled thorough QT study.
Topics: Acetanilides; Adolescent; Adrenergic beta-Agonists; Adult; Anti-Infective Agents; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Sex Characteristics; Thiazoles; Urinary Bladder, Overactive; Young Adult | 2012 |
Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Anticoagulants; Aza Compounds; Benzamides; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Pyridines; Quinolines; Young Adult | 2013 |
A randomized, double-blind, placebo-controlled study to evaluate the effect of repeated oral doses of pazopanib on cardiac conduction in patients with solid tumors.
Topics: Adult; Aged; Algorithms; Angiogenesis Inhibitors; Anti-Bacterial Agents; Aza Compounds; Blood Pressure; Confidence Intervals; Double-Blind Method; Electrocardiography, Ambulatory; Female; Fluoroquinolones; Heart Conduction System; Heart Rate; Humans; Indazoles; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Neoplasms; Pyrimidines; Quinolines; Sulfonamides; Young Adult | 2013 |
Identifying the translational gap in the evaluation of drug-induced QTc interval prolongation.
Topics: Adolescent; Adult; Animals; Aza Compounds; Bayes Theorem; Cisapride; Cross-Over Studies; Dogs; Double-Blind Method; Drug Evaluation, Preclinical; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Models, Biological; Moxifloxacin; Probability; Quinolines; Single-Blind Method; Sotalol; Species Specificity; Translational Research, Biomedical; Young Adult | 2013 |
Clinical assessment of drug-induced QT prolongation in association with heart rate changes.
Topics: Adrenergic alpha-Antagonists; Adult; Aza Compounds; Cross-Over Studies; Double-Blind Method; Electrocardiography; Electrocardiography, Ambulatory; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Predictive Value of Tests; Quinazolines; Quinolines; Reproducibility of Results; Treatment Outcome | 2005 |
Effects of moxifloxacin on QT interval in conscious dogs.
Topics: Animals; Anti-Arrhythmia Agents; Aza Compounds; Blood Pressure; Body Temperature; Cardiac Output; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Fluoroquinolones; Heart Conduction System; Infusions, Intravenous; Long QT Syndrome; Male; Moxifloxacin; Quinolines; Reference Values | 2005 |
Effects of three fluoroquinolones on QT analysis after standard treatment courses.
Topics: Analysis of Variance; Aza Compounds; Ciprofloxacin; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Levofloxacin; Long QT Syndrome; Male; Moxifloxacin; Ofloxacin; Quinolines; Statistics, Nonparametric; Torsades de Pointes | 2006 |
Man versus machine: is there an optimal method for QT measurements in thorough QT studies?
Topics: Adolescent; Adult; Aza Compounds; Control Groups; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Humans; Ketoconazole; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Reproducibility of Results; Research Design; Signal Processing, Computer-Assisted | 2006 |
Ritonavir 100 mg does not cause QTc prolongation in healthy subjects: a possible role as CYP3A inhibitor in thorough QTc studies.
Topics: Adult; Aza Compounds; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electrocardiography; Female; Fluoroquinolones; Heart Rate; HIV Protease Inhibitors; Humans; Imidazoles; Ketoconazole; Liver; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Reference Values; Reproducibility of Results; Research Design; Reverse Transcriptase Inhibitors; Ritonavir; Sulfur Compounds; Treatment Outcome | 2008 |
Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study.
Topics: Adolescent; Adult; Aza Compounds; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography, Ambulatory; Female; Fluoroquinolones; Heart Rate; Histamine H1 Antagonists, Non-Sedating; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Piperazines; Quinolines | 2007 |
44 other study(ies) available for moxifloxacin and Long QT Syndrome
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent.
Topics: Animals; Antitubercular Agents; Long QT Syndrome; Mycobacterium tuberculosis; Tuberculosis, Multidrug-Resistant | 2022 |
Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens.
Topics: Antitubercular Agents; C-Reactive Protein; Cytokines; Electrocardiography; Humans; Interleukin-6; Long QT Syndrome; Moxifloxacin; Rifampin; Tuberculosis, Multidrug-Resistant; Tumor Necrosis Factor-alpha | 2022 |
Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs.
Topics: Animals; Arrhythmias, Cardiac; Dogs; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Ether-A-Go-Go Potassium Channels; Heart Rate; Long QT Syndrome; Moxifloxacin; Quinidine; Reflex; Torsades de Pointes | 2022 |
Development and Validation of a Nomogram for Prediction of QT Interval Prolongation in Patients Administered Bedaquiline-Containing Regimens in China: a Modeling Study.
Topics: Antitubercular Agents; Clofazimine; Creatinine; Diarylquinolines; Humans; Levofloxacin; Long QT Syndrome; Moxifloxacin; Nomograms; Tuberculosis, Multidrug-Resistant | 2022 |
Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration-QTc analysis.
Topics: Animals; Dogs; Fluoroquinolones; Humans; Long QT Syndrome; Macaca fascicularis; Moxifloxacin; Telemetry | 2023 |
Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.
Topics: Dose-Response Relationship, Drug; Double-Blind Method; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Moxifloxacin; Receptors, Estrogen | 2023 |
The "One-Step" approach for QT analysis increases the sensitivity of nonclinical QTc analysis.
Topics: Animals; Electrocardiography; Heart; Heart Rate; Long QT Syndrome; Moxifloxacin | 2023 |
R on T Phenomenon and Long QTc Syndrome due to Moxifloxacin in a Healthy Female.
Topics: Anti-Bacterial Agents; Community-Acquired Infections; Electrocardiography; Female; Humans; Long QT Syndrome; Middle Aged; Moxifloxacin; Pneumonia, Bacterial | 2019 |
A Computational Pipeline to Predict Cardiotoxicity: From the Atom to the Rhythm.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotoxicity; Cardiotoxins; Computer Simulation; Drug Discovery; ERG1 Potassium Channel; Female; Humans; Long QT Syndrome; Machine Learning; Male; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Protein Structure, Secondary; Sulfonamides; Topoisomerase II Inhibitors | 2020 |
A Pooled Analysis of Three Randomized Phase I/IIa Clinical Trials Confirms Absence of a Clinically Relevant Effect on the QTc Interval by Umibecestat.
Topics: Adult; Aged; Aged, 80 and over; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Oxazines; Randomized Controlled Trials as Topic; Young Adult | 2020 |
Baseline selection in concentration-QTc modeling: impact on assay sensitivity.
Topics: Biological Assay; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Moxifloxacin; Research Design | 2021 |
Concentration-QTc analysis for single arm studies.
Topics: Clinical Trials, Phase I as Topic; Computer Simulation; Cross-Over Studies; Datasets as Topic; Dose-Response Relationship, Drug; Electrocardiography; Healthy Volunteers; Humans; Long QT Syndrome; Models, Biological; Moxifloxacin; Research Design; Time Factors | 2021 |
Evaluation of moxifloxacin in canine and non-human primate telemetry assays: Comparison of QTc interval prolongation by timepoint and concentration-QTc analysis.
Topics: Animals; Cross-Over Studies; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Long QT Syndrome; Moxifloxacin; Primates; Telemetry | 2021 |
Proarrhythmic risk assessment using conventional and new in vitro assays.
Topics: Action Potentials; Anti-Arrhythmia Agents; Arsenic; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Fluoroquinolones; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells; Long QT Syndrome; Moxifloxacin; Myocytes, Cardiac; Pentamidine; Phenethylamines; Risk Assessment; Sulfonamides | 2017 |
Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome.
Topics: Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoroquinolones; Halothane; Heart Rate; Long QT Syndrome; Male; Moxifloxacin; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Swine; Swine, Miniature; Terfenadine | 2017 |
Population pharmacokinetics of moxifloxacin and its concentration-QT interval relationship modeling in Chinese healthy volunteers.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Asian People; China; Computer Simulation; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Female; Fluoroquinolones; Gastrointestinal Absorption; Healthy Volunteers; Heart Rate; Humans; Linear Models; Long QT Syndrome; Male; Metabolic Clearance Rate; Models, Biological; Moxifloxacin; Nonlinear Dynamics; Young Adult | 2017 |
Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin.
Topics: Algorithms; Anti-Bacterial Agents; ERG1 Potassium Channel; Heart; Humans; Long QT Syndrome; Models, Biological; Moxifloxacin; Risk Assessment; Torsades de Pointes; Translational Research, Biomedical | 2018 |
Safety and Tolerability of Moxifloxacin in Children.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Alanine Transaminase; Anti-Bacterial Agents; Aspartate Aminotransferases; Bacterial Infections; Bilirubin; Blood Cell Count; Child; Child, Preschool; Drug Administration Schedule; Female; Fluoroquinolones; Humans; Infant; Long QT Syndrome; Male; Moxifloxacin; Neutropenia; Retrospective Studies; Seizures | 2018 |
Assay sensitivity in "Hybrid thorough QT/QTc (TQT)" study.
Topics: Biological Assay; Control Groups; Cross-Over Studies; Dose-Response Relationship, Drug; Drugs, Investigational; Electrocardiography; Heart Rate; Humans; Linear Models; Long QT Syndrome; Moxifloxacin; Randomized Controlled Trials as Topic; Research Design; Sensitivity and Specificity | 2019 |
Effects of probucol, a typical hERG expression inhibitor, on in vivo QT interval prolongation in conscious dogs.
Topics: Animals; Anticholesteremic Agents; Aza Compounds; Dogs; Drug Interactions; Ether-A-Go-Go Potassium Channels; Fluoroquinolones; Long QT Syndrome; Male; Moxifloxacin; Probucol; Quinolines | 2013 |
The application of root mean square electrocardiography (RMS ECG) for the detection of acquired and congenital long QT syndrome.
Topics: Adolescent; Adult; Cardiotonic Agents; Case-Control Studies; Child; Child, Preschool; Data Interpretation, Statistical; Electrocardiography, Ambulatory; Female; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Randomized Controlled Trials as Topic; Young Adult | 2014 |
The Power of Phase I Studies to Detect Clinical Relevant QTc Prolongation: A Resampling Simulation Study.
Topics: Clinical Trials, Phase I as Topic; Computer Simulation; Cross-Over Studies; Data Collection; Data Interpretation, Statistical; Electrocardiography; False Negative Reactions; False Positive Reactions; Fluoroquinolones; Healthy Volunteers; Humans; Long QT Syndrome; Moxifloxacin; Randomized Controlled Trials as Topic; Time Factors | 2015 |
Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans.
Topics: Adolescent; Adult; Algorithms; Animals; Anti-Bacterial Agents; Clinical Trials, Phase I as Topic; Dogs; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Macaca fascicularis; Male; Middle Aged; Moxifloxacin; Randomized Controlled Trials as Topic; Risk Assessment; Species Specificity; Young Adult | 2016 |
Pharmacokinetic-pharmacodynamic modelling of drug-induced QTc interval prolongation in man: prediction from in vitro human ether-à-go-go-related gene binding and functional inhibition assays and conscious dog studies.
Topics: Animals; Binding Sites; Cells, Cultured; Cisapride; Consciousness; Dogs; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Fluoroquinolones; Humans; Long QT Syndrome; Male; Models, Animal; Models, Biological; Moxifloxacin; Phenethylamines; Structure-Activity Relationship; Sulfonamides | 2016 |
Automated QT measurement and application to detection of moxifloxacin-induced changes.
Topics: Algorithms; Aza Compounds; Electrocardiography, Ambulatory; Female; Fluoroquinolones; Heart Failure; Humans; Long QT Syndrome; Male; Moxifloxacin; Quinolines; Signal Processing, Computer-Assisted | 2009 |
Comparison of manual and automated measurements of the QT interval in healthy volunteers: an analysis of five thorough QT studies.
Topics: Automation; Aza Compounds; Controlled Clinical Trials as Topic; Cross-Over Studies; Diagnosis, Computer-Assisted; Electrocardiography; Fluoroquinolones; Humans; Long QT Syndrome; Moxifloxacin; Quinolines; Time Factors | 2009 |
Moxifloxacin-induced QT prolongation and torsades: an uncommon effect of a common drug.
Topics: Anti-Infective Agents; Aza Compounds; Electrocardiography; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Torsades de Pointes | 2009 |
Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I(Ks).
Topics: Animals; Antibiotics, Antineoplastic; Aza Compounds; Cardiovascular Agents; Cell Line; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation, Preclinical; Ether-A-Go-Go Potassium Channels; Fluoroquinolones; Guinea Pigs; Humans; In Vitro Techniques; Inhibitory Concentration 50; Long QT Syndrome; Moxifloxacin; Quinolines; Razoxane | 2010 |
Moxifloxacin: new indication. Inadequate restriction of indications in ENT and respiratory infections.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Bronchitis; Chemical and Drug Induced Liver Injury; Europe; Fluoroquinolones; Humans; Long QT Syndrome; Moxifloxacin; Pneumococcal Infections; Quinolines; Respiratory Tract Infections; Safety-Based Drug Withdrawals; Sinusitis; Stevens-Johnson Syndrome | 2009 |
Highly automated QT measurement techniques in 7 thorough QT studies implemented under ICH E14 guidelines.
Topics: Anti-Infective Agents; Aza Compounds; Cardiotoxins; Drug Evaluation, Preclinical; Electrocardiography; Female; Fluoroquinolones; Guidelines as Topic; Heart Conduction System; Humans; Long QT Syndrome; Male; Models, Biological; Moxifloxacin; Neuromuscular Nondepolarizing Agents; Quinolines; Sex Factors | 2011 |
[Practical ECG problems in the elderly patient. Case number 16. Moxifloxacin-associated QT interval prolongation].
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Anti-Infective Agents; Atenolol; Aza Compounds; Bradycardia; Electrocardiography; Female; Fluoroquinolones; Humans; Long QT Syndrome; Moxifloxacin; Quinolines | 2011 |
Characterization of the human QT interval: novel distribution-based assessment of the repolarization effects of moxifloxacin.
Topics: Adult; Aza Compounds; Electrocardiography; Female; Fluoroquinolones; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Young Adult | 2012 |
Update on the cardiac safety of moxifloxacin.
Topics: Administration, Oral; Age Factors; Aged; Animals; Anti-Infective Agents; Aza Compounds; Drug Labeling; Female; Fluoroquinolones; Heart Diseases; Humans; Infusions, Intravenous; Long QT Syndrome; Male; Moxifloxacin; Quinolines; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors | 2012 |
In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome.
Topics: Administration, Oral; Animals; Aza Compounds; Blood Pressure; Chloralose; Disease Models, Animal; Dogs; Electrocardiography; Female; Fluoroquinolones; Gatifloxacin; Halothane; Heart Block; Heart Rate; Infusions, Intravenous; Long QT Syndrome; Male; Moxifloxacin; Quinolines; Rabbits; Risk Assessment; Time Factors; Torsades de Pointes; Ventricular Function, Left | 2004 |
QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome.
Topics: Action Potentials; Animals; Anti-Infective Agents; Area Under Curve; Arrhythmias, Cardiac; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenethylamines; Potassium Channels, Inwardly Rectifying; Quinolines; Rabbits; Sulfonamides; Telemetry; Treatment Outcome | 2005 |
No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Arrhythmias, Cardiac; Aza Compounds; Azithromycin; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Electrophysiology; Fluoroquinolones; Heart Block; Heart Rate; Long QT Syndrome; Moxifloxacin; Phenethylamines; Quinolines; Sulfonamides; Torsades de Pointes | 2006 |
Torsade de pointes associated with moxifloxacin: a rare but potentially fatal adverse event.
Topics: Aged, 80 and over; Anti-Infective Agents; Aza Compounds; Bradycardia; Cardiac Pacing, Artificial; Female; Fluoroquinolones; Humans; Long QT Syndrome; Moxifloxacin; Pneumonia; Quinolines; Risk Factors; Syncope; Torsades de Pointes; Treatment Outcome | 2007 |
Improving the detection of subtle I(Kr)-inhibition: assessing electrocardiographic abnormalities of repolarization induced by moxifloxacin.
Topics: Adolescent; Adult; Anti-Infective Agents; Aza Compounds; Delayed Rectifier Potassium Channels; Diagnosis, Computer-Assisted; Electrocardiography; Female; Fluoroquinolones; Humans; Logistic Models; Long QT Syndrome; Male; Moxifloxacin; Quinolines; Retrospective Studies | 2008 |
A statistical assessment of QT data following placebo and moxifloxacin dosing in thorough QT studies.
Topics: Anti-Infective Agents; Aza Compounds; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Guidelines as Topic; Heart Rate; Humans; Long QT Syndrome; Male; Meta-Analysis as Topic; Models, Statistical; Moxifloxacin; Placebos; Quinolines; Randomized Controlled Trials as Topic | 2008 |
Validation testing in thorough QT/QTc clinical trials.
Topics: Anti-Infective Agents; Aza Compounds; Control Groups; Electrocardiography; Fluoroquinolones; Guidelines as Topic; Heart Rate; Humans; Long QT Syndrome; Moxifloxacin; Placebos; Quinolines; Randomized Controlled Trials as Topic; Validation Studies as Topic | 2008 |
Statistical issues of QT prolongation assessment based on linear concentration modeling.
Topics: Anti-Infective Agents; Aza Compounds; Electrocardiography; Fluoroquinolones; Guidelines as Topic; Heart Rate; Humans; International Cooperation; Linear Models; Long QT Syndrome; Moxifloxacin; Quinolines; Randomized Controlled Trials as Topic; Sample Size; Time Factors | 2008 |
Potassium current antagonist properties and proarrhythmic consequences of quinolone antibiotics.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Arrhythmias, Cardiac; Aza Compounds; Cation Transport Proteins; DNA-Binding Proteins; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoroquinolones; Gatifloxacin; Long QT Syndrome; Mice; Models, Animal; Moxifloxacin; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quinolines; Rabbits; Trans-Activators; Tumor Cells, Cultured | 2001 |
The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis.
Topics: Action Potentials; Animals; Anti-Infective Agents; Arrhythmias, Cardiac; Aza Compounds; Cisapride; Dogs; Erythromycin; Female; Fluoroquinolones; Imidazoles; In Vitro Techniques; Indoles; Long QT Syndrome; Male; Models, Biological; Moxifloxacin; Perfusion; Piperazines; Purkinje Fibers; Quinolines; Sotalol; Swine; Torsades de Pointes | 2001 |