moxidectin and Clostridium-Infections

To assess the efficacy and safety of a formulation containing moxidectin and 6 in 1 vaccine in sheep under field conditions.. Efficacy and safety study.. Two hundred and five crossbred Merino lambs and two hundred and eight Merino ewes were used in the studies.. A formulation was made for the simultaneous treatment of sheep with moxidectin and immunisation against clostridial diseases and caseous lymphadenitis. The efficacy against nematodes, vaccine response and safety were assessed.. Effective control of nematodes and responses to antigens were achieved following subcutaneous administration. The formulation was safe to administer; occasional minor tissue reactions were evident, but no other adverse effects of treatment were observed in either pregnant ewes or lambs, using either the recommended dose, or an overdose of the formulation.. Administration of a formulation containing moxidectin, five clostridial antigens and caseous lymphadenitis antigen proved safe and efficacious under field conditions.

Topics: Animals; Anthelmintics; Anti-Bacterial Agents; Antibodies; Antigens; Clostridium; Clostridium Infections; Dose-Response Relationship, Drug; Female; Lymphadenitis; Macrolides; Nematode Infections; New South Wales; Pregnancy; Sheep; Sheep Diseases; Vaccination; Vaccines, Inactivated