motilin and Helicobacter-Infections

The present study was designed to observe the effect of quadruple therapy combined with probiotics on

Topics: Amoxicillin; Anti-Bacterial Agents; Bismuth; Drug Therapy, Combination; Gastrins; Helicobacter Infections; Helicobacter pylori; Humans; Metronidazole; Motilin; Pectins; Peptic Ulcer; Probiotics; Proton Pump Inhibitors; Somatostatin; Tablets, Enteric-Coated

To establish the role of the main risk factors and endocrine cells of the antrum of the stomach producing motilin (M-cells) in the occurrence of cholelithiasis.. The first group included 122 patients with cholelithiasis. The second group consisted of 30 healthy individuals who underwent medical examination. The groups were matched for gender and age. The work analyzed anamnestic, biochemical and anthropometric data. All patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucous membrane from the antrum. Biopsies were subjected to cytological and immunohistochemical studies in order to verify Helicobacter pylori and estimate the number of M-cells.. Patients with cholelithiasis more often belonged to the group of people of mental labor, had low physical activity, were committed to inappropriate nutrition and more often indicated the presence of aggravated heredity for cholelithiasis. Patients with gallstone disease had higher body mass index, waist volume, total cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, lower high-density lipoprotein cholesterol, H. pylori infection was more often verified and M-cell hypoplasia in the mucous membrane was established. stomach in comparison with the representatives of the second group.. Our results suggest that certain external factors, nutritional characteristics of the metabolic syndrome components, hypoplasia of M-cells in the gastric mucosa are important factors in the formation of calculi in the gallbladder.. Цель. Установить роль основных факторов риска и эндокринных клеток антрального отдела желудка, продуцирующих мотилин (М-клетки), в возникновении желчнокаменной болезни (ЖКБ). Материалы и методы. В 1-ю группу включены 122 пациента с ЖКБ; 2-ю группу составили 30 здоровых лиц, прошедших диспансеризацию. Группы сопоставимы по полу и возрасту. В работе анализировались анамнестические, биохимические и антропометрические данные. Всем пациентам выполнялась эзофагогастродуоденоскопия с прицельной биопсией слизистой оболочки из антрального отдела желудка. Биоптаты подвергнуты цитологическому и иммуногистохимическому исследованию с целью верификации Helicobacter pylori и оценки количества М-клеток. Результаты. Пациенты с ЖКБ чаще относились к группе лиц умственного труда, имели низкую физическую активность, оказались привержены нерациональному питанию и чаще указывали на наличие отягощенной наследственности по ЖКБ. У пациентов с ЖКБ отмечались более высокие показатели индекса массы тела, объема талии, уровня общего холестерина (ХС), ХС липопротеидов низкой плотности, триглицеридов, глюкозы, более низкий уровень ХС липопротеидов высокой плотности, чаще верифицировалась инфекция H. pylori и установлена гипоплазия М-клеток в слизистой оболочке желудка по сравнению с представителями 2-й группы. Заключение. Полученные нами результаты дают основание сделать вывод о том, что определенные внешние факторы, особенности питания, компоненты метаболического синдрома, гипоплазия М-клеток в слизистой оболочке желудка являются важными факторами формирования конкрементов в желчном пузыре.

Topics: Cholelithiasis; Cholesterol; Endocrine Cells; Gastric Mucosa; Glucose; Helicobacter Infections; Helicobacter pylori; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Motilin; Risk Factors; Stomach; Triglycerides

To evaluate the occurrence of gastroesophageal reflux and possible mechanisms in Helicobacter pylori infection.. Symptoms of H. pylori-infected children, their total gastroesophageal reflux episodes, acid exposure percentage, gastrin, ghrelin, and motilin levels were evaluated before and after H. pylori eradication.. Forty-two H. pylori-infected children were eligible for this study. Acid exposure % and total reflux episodes before and after H. pylori eradication were 10.2%±14.8% vs. 7.71%±5.0% and 94.7%±102.1% vs. 64.6%±55.0%, respectively (p=0.28, p=0.082). There was an insignificant change in the serum gastrin (93.4±153.8 pmol/L vs. 1.28±149.4 pmol/L, p=0.67), ghrelin (7.69±197.5 pg/mL vs. 8.36±299.5 pg/mL, p=0.274), and motilin (75.1±81.2 pg/mL vs. 97.2±80.5 pg/mL, p=0.206) levels after eradication. Gastrin and ghrelin levels were negatively correlated after H. pylori eradication (r=-0.38, p=0.031). There was no association between gastroesophageal reflux episodes and gastrin, ghrelin, and motilin levels (r=0.25 and p=0.11; r= 0.24 and p=0.13; r=-0.23 and p=0.14, respectively).. H. pylori infection is neither protective nor harmful in the gastroesophageal reflux. Neither ghrelin nor motilin levels was associated with gastroesophageal reflux. None of gastrin, ghrelin, and motilin levels was affected by H. pylori infection. There is an inverse association between gastrin and ghrelin levels after H. pylori eradication.

Topics: Adolescent; Biomarkers; Child; Female; Follow-Up Studies; Gastrins; Gastroesophageal Reflux; Ghrelin; Helicobacter Infections; Humans; Incidence; Male; Motilin; Prognosis; Prospective Studies; Turkey

Helicobacter pylori infection is associated with complex alterations of the gastric physiology in patients with ulcer disease or functional dyspepsia. We aimed at evaluating whether H. pylori infection is accompanied by changes in interdigestive and postprandial gastrointestinal motility, exocrine pancreatic secretion or hormone release in asymptomatic subjects.. Nineteen healthy men (age range 26-35 years) were studied after 12 h fasting. Motor activity was recorded for a complete motor migrating complex cycle and two postprandial hours. Pancreatic enzyme secretion was evaluated using a standard duodenal perfusion technique. Plasma concentrations of gastrin, PP and motilin were determined at 15-min intervals. H. pylori infection was proved by serology and 13C-urea breath test.. Eight subjects (42%) were H. pylori positive. Interdigestive and postprandial gastrointestinal motility were similar in H. pylori positive and negative subjects. Interdigestive pancreatic secretion was increased in H. pylori positive subjects (P < 0.05). Postprandial pancreatic secretion tended also to be higher in H. pylori positive subjects. H. pylori infection was associated with an increased postprandial release of gastrin (P < 0.05) as well as with a slight increase of interdigestive gastrin release. The release of PP and motilin, as well as the interdigestive coordination between gastrointestinal motility, pancreatic secretion and hormone release, was not altered by H. pylori infection.. H. pylori infection in asymptomatic subjects is associated with changes not only in gastric physiology but also in pancreatic function. This first reported link between H. pylori and the pancreas could have pathophysiological implications in pancreatic diseases and therefore deserves further study.

Topics: Adult; Amylases; Chymotrypsin; Gastrins; Gastrointestinal Motility; Helicobacter Infections; Helicobacter pylori; Humans; Lipase; Male; Motilin; Pancreas; Pancreatic Polypeptide