motilin and Atrophy

Chronic atrophic gastritis is a very common condition in the general clinical practice of gastroenterology. Tuina treatment is widely used clinically. The aim of our study was to investigate the mechanisms of tuina in rats with chronic atrophic gastritis.. Fifty-six specific pathogen-free grade rats were employed for our study. They were divided into 5 groups and treated differ- ently. Body weight was recorded every week, and their small intestine propulsive ratio was measured after intragastric administration of carbon powder. Histopathological observation of gastric tissues was performed using hematoxylin and eosin staining. The levels of motilin and gastrin in serum were detected by enzyme-linked immunosorbent assay, and the expression levels of Bcl-2 and cytochrome C were measured by the western blot assay.. There was no significant difference in body weight and small intestine propulsive ratio between the chronic atrophic gastritis model group and the tuina group (P > .05). However, we can see some significant changes in histomorphology after treatment with tuina. For example, the atrophy of gastric mucosal epithelium and glands had improved, and the inflammatory cells infiltrating the lamina propria were decreased significantly. Moreover, the level of gastrointestinal hormone GAS was increased (P < .001), and there was no statistically significant difference in motilin, Bcl-2, and cytochrome-c after treatment with tuina (P > .05).. Our research demonstrated the effectiveness of tuina treatment on chronic atrophic gastritis with a possible underlying mechanism that affected the secretion of gastric acid, which could provide some useful information for clinical application.

Topics: Animals; Atrophy; Body Weight; Gastric Mucosa; Gastritis, Atrophic; Massage; Motilin; Rats

The aim of the study was to determine the clinical significance of intestinal functional and structural alterations in biliary pathology. Clinical, endoscopic, morphological, and morphometric methods were used. The subjects of the study were 62 patients with functional gall bladder disorder, 90 patients with chronic calculous cholecystitis, and 90 patients who had undergone cholecystectomy for cholelithiasis. The study found that biliary lithogenesis was associated with intestinal dysbiosis, changes in the qualitative density of erythrocytes immunopositive to motilin and substance P, and inflammatory changes in the intestines. After cholecystectomy, changes in intestinal microecology progressed, inflammatory and atrophic changes in the intestinal mucosa appeared or deepened, the qualitative density of erythrocytes immunopositive to motilin and substance P decreased, and colon polyps appeared more frequently.

Topics: Adult; Aged; Atrophy; Cholecystitis; Cholelithiasis; Chronic Disease; Colonic Polyps; Diagnosis, Differential; Erythrocyte Count; Erythrocytes; Female; Humans; Inflammation; Intestinal Mucosa; Male; Middle Aged; Motilin; Predictive Value of Tests; Prognosis; Substance P

The results suggest that in the pancreatic atrophy the interrelations of gastrointestinal hormones are changed. These changes may be involved in the maintenance of the relatively high hormonal responses to feeding in the pancreatic atrophy.

Topics: Animals; Atrophy; Dogs; Eating; Gastrins; Gastrointestinal Hormones; Motilin; Pancreatic Diseases; Pancreatic Polypeptide

One-hour postprandial responses of plasma concentrations of pancreatic polypeptide, gastrin and motilin were measured in 4 dogs during 31 months of pancreatic atrophy development, produced by obstructing their pancreatic juice flow. Basal pancreatic polypeptide and gastrin concentrations decreased, while motilin concentration did not. During this period the animals displayed a significant postprandial response. These findings suggest that hormonal mechanisms involved in the digestive process are maintained in the period of the sharp disturbance of the pancreatic exocrine function.

Topics: Amylases; Animals; Atrophy; Bicarbonates; Dogs; Gastrins; Gastrointestinal Hormones; Motilin; Pancreatic Diseases; Pancreatic Juice; Pancreatic Polypeptide; Peptide Hydrolases

Topics: Animals; Atrophy; Diet; Digestion; Dogs; Gastrins; Gastrointestinal Hormones; Insulin; Meat; Motilin; Pancreatic Diseases; Pancreatic Polypeptide

Topics: Animals; Atrophy; Dogs; Food; Gastrins; Gastrointestinal Hormones; Motilin; Pancreatic Diseases; Pancreatic Polypeptide; Time Factors

Fasting and postprandial concentrations of pancreatic polypeptide, gastrin and motilin were measured during 2hrs after meat feeding. The byphasic rise of pancreatic polypeptide concentration occurred in 15 and 120 min and increase of gastrin concentration--in 15 min after feeding. Increase of motilin concentration occurred during the second hour. These findings complete our previous data and suggest that hormonal mechanisms involved in postprandial response are maintained even in pancreatic atrophy.

Topics: Animals; Atrophy; Digestion; Dogs; Gastrins; Gastrointestinal Hormones; Meat; Motilin; Pancreatic Diseases; Pancreatic Polypeptide; Time Factors

One hour postprandial responses of plasma concentrations of pancreatic polypeptide, gastrin and motilin were detected in healthy dogs. Pancreatic atrophy was produced in these animals by obstructing their pancreatic juice flow. Basal hormone concentrations in four animals did not change significantly during 11 months of pancreatic atrophy. During this period the animals displayed a significant postprandial response. These preliminary results suggest that hormonal mechanisms involved in the digestive process are maintained during pancreatic atrophy.

Topics: Amylases; Animals; Atrophy; Bicarbonates; Dogs; Fasting; Gastrins; Gastrointestinal Hormones; Motilin; Pancreas; Pancreatic Diseases; Pancreatic Juice; Pancreatic Polypeptide; Peptide Hydrolases