morphine-chloride and Hypothermia

morphine-chloride has been researched along with Hypothermia* in 1 studies

Other Studies

1 other study(ies) available for morphine-chloride and Hypothermia

Article	Year
Synthesis of spiro[tetralin-2,2'-pyrrolidine] and spiro[indan-2,2'-pyrrolidine] derivatives as potential analgesics. Journal of medicinal chemistry, 1978, Volume: 21, Issue:6 Spiro[tetralin-2,2'-pyrrolidine] (13) and spiro[6-methoxytetralin-2,2'-pyrrolidine] (17) were prepared by initial Michael condensation of 2-nitrotetralin and 6-methoxy-2-nitrotetralin, respectively, with methyl acrylate to give 7 and 8, both of which could be reductively cyclized to 10 and 11, followed by LiAlH4 reduction. Spiro[indan-2,2'-pyrrolidine] (15) was prepared in an analogous manner form 2-nitroindan, and spiro[6-hydroxytetralin-2,2'-pyrrolidine] (19) was prepared by O-demethylation of 17. Compound 13 and its N-methyl derivative, 14, both showed good analgesic activity. Compounds 13-16 all possessed weak antidepressant properties, but neither 19 nor its N-methyl derivative 20 had any significant CNS activity. Topics: Acetates; Analgesics; Animals; Antidepressive Agents; Hypothermia; Indans; Indenes; Mice; Naphthalenes; Pyrrolidines; Reserpine; Spasm; Spiro Compounds; Tetrahydronaphthalenes	1978

Article

Year

Synthesis of spiro[tetralin-2,2'-pyrrolidine] and spiro[indan-2,2'-pyrrolidine] derivatives as potential analgesics.

Journal of medicinal chemistry, 1978, Volume: 21, Issue:6

Spiro[tetralin-2,2'-pyrrolidine] (13) and spiro[6-methoxytetralin-2,2'-pyrrolidine] (17) were prepared by initial Michael condensation of 2-nitrotetralin and 6-methoxy-2-nitrotetralin, respectively, with methyl acrylate to give 7 and 8, both of which could be reductively cyclized to 10 and 11, followed by LiAlH4 reduction. Spiro[indan-2,2'-pyrrolidine] (15) was prepared in an analogous manner form 2-nitroindan, and spiro[6-hydroxytetralin-2,2'-pyrrolidine] (19) was prepared by O-demethylation of 17. Compound 13 and its N-methyl derivative, 14, both showed good analgesic activity. Compounds 13-16 all possessed weak antidepressant properties, but neither 19 nor its N-methyl derivative 20 had any significant CNS activity.

Topics: Acetates; Analgesics; Animals; Antidepressive Agents; Hypothermia; Indans; Indenes; Mice; Naphthalenes; Pyrrolidines; Reserpine; Spasm; Spiro Compounds; Tetrahydronaphthalenes

1978