morphine and Reperfusion-Injury

We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbolines; Crystallography, X-Ray; Dose-Response Relationship, Drug; Edema; Male; Mesenteric Arteries; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Oligopeptides; Rats; Rats, Wistar; Reperfusion Injury; Stereoisomerism; Xylenes