morphine and Pancreatitis

Topics: Adolescent; Adult; Appetite; Child; Child, Preschool; Cystic Fibrosis; Diabetes Complications; Female; Growth Disorders; Humans; Hypertension, Portal; Infant; Infant, Newborn; Intestinal Diseases; Intestinal Obstruction; Intussusception; Lactose Intolerance; Liver Cirrhosis; Male; Meconium; Pancreas; Pancreatitis; Rectal Prolapse

In this work, we are interested to study the implication of -509C/T polymorphism, located in the promoter region of TGFB1 (transforming growth factor β1), in the phenotypic variability of CF patients.. The present study enrolled 111 CF patients and 100 healthy control subjects. The study of the -509C/T polymorphism was performed using PCR-RFLP method.. We found that patients carried non-F508del homozygous mutation with TT genotype was associated to lung symptoms (P=0.04). This association was not found in the sub-groups of patients with F508del at homozygous state P=0.145. No association was found between this polymorphism and the variability of digestive, pancreatic and ileus meconial symptoms.. On the basis of our results, the -509C/T polymorphism of the TGFB1 gene seems to be a modulator factor of cystic fibrosis.

Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diabetes Mellitus; Digestive System Diseases; Female; Humans; Ileus; Infant; Infant, Newborn; Male; Meconium; Pancreatitis; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Respiratory Insufficiency; Transforming Growth Factor beta1; Young Adult

Topics: Appendicitis; Child; Child, Preschool; Diagnosis, Differential; Enterocolitis, Pseudomembranous; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Intestinal Perforation; Intussusception; Meckel Diverticulum; Meconium; Pancreatitis; Peptic Ulcer Perforation; Peritonitis; Radiography

Topics: Congenital Abnormalities; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Meconium; Pancreas; Pancreatic Neoplasms; Pancreatitis; Surgical Procedures, Operative