morphine has been researched along with Nociceptive-Pain* in 1 studies
1 other study(ies) available for morphine and Nociceptive-Pain
| Article | Year |
|---|---|
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).
An improved synthetic method for triplet drugs with the 1,3,5-trioxazatriquinane skeleton was developed that used p-toluenesulfonylmethyl isocyanide (TosMIC) instead of 1,3-dithiane. Using the improved method, we synthesized compounds with two identical pharmacophore units and an epoxymethano group, that is, capped homotriplets. Among the synthesized capped homotriplets, KNT-123 showed high selectivity for the μ receptor over the κ receptor, and the μ selectivity was the highest among the reported μ selective nonpeptide ligands. KNT-123 administered subcutaneously induced a dose-dependent analgesic effect in the acetic acid writhing assay, and its potency was 11-fold more potent than that of morphine. KNT-123 may serve as a useful tool for the study of the pharmacological actions mediated specifically via the μ receptor. Topics: Analgesics, Opioid; Animals; Bridged-Ring Compounds; Mice; Models, Molecular; Nitriles; Nociception; Nociceptive Pain; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sesquiterpenes; Tosyl Compounds | 2011 |