morphine and Diabetes-Mellitus

Topics: Adrenalectomy; Aging; Animals; Animals, Newborn; Bile Acids and Salts; Cholesterol; Diabetes Mellitus; Female; Glucocorticoids; Homeostasis; Humans; Liver; Meconium; Pregnancy; Rats; Sterols; Thyroidectomy

With the rise in genetic screening both pre- and postnatally, new variances in genes are being recognized. Some are of unknown significance, while other known genetic expressions have obvious phenotypical expressions. Transient neonatal diabetes mellitus is a result of the duplication of chromosome 6q24, but little is known about the phenotypic expression of a triplication of chromosome 6q24. This case study presents an infant with a postnatally diagnosed triplication of chromosome 6q24, meconium pseudocyst, and multiple congenital anomalies with unknown genetic significance.

Topics: Abnormalities, Multiple; Cysts; Diabetes Mellitus; Humans; Infant, Newborn; Male; Meconium

In this work, we are interested to study the implication of -509C/T polymorphism, located in the promoter region of TGFB1 (transforming growth factor β1), in the phenotypic variability of CF patients.. The present study enrolled 111 CF patients and 100 healthy control subjects. The study of the -509C/T polymorphism was performed using PCR-RFLP method.. We found that patients carried non-F508del homozygous mutation with TT genotype was associated to lung symptoms (P=0.04). This association was not found in the sub-groups of patients with F508del at homozygous state P=0.145. No association was found between this polymorphism and the variability of digestive, pancreatic and ileus meconial symptoms.. On the basis of our results, the -509C/T polymorphism of the TGFB1 gene seems to be a modulator factor of cystic fibrosis.

Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diabetes Mellitus; Digestive System Diseases; Female; Humans; Ileus; Infant; Infant, Newborn; Male; Meconium; Pancreatitis; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Respiratory Insufficiency; Transforming Growth Factor beta1; Young Adult

To externally validate two previously developed prognostic models that predict the risk for developing metabolic acidosis in newborns using both antepartum (model 1) and intrapartum (combined with antepartum, model 2) risk factors: parity, previous cesarean section, maternal diabetes mellitus, gestational age, induced onset of labor, meconium-stained amniotic fluid, and use of ST analysis.. The two prediction models were applied in women in active labor at more than 36 gestational weeks with singleton fetuses in cephalic presentation and with high-risk pregnancies (n = 5049) who were included in a Swedish randomized trial between December 1, 1998, and June 4, 2000. The prognostic ability of the models was determined using calibration and discrimination measures.. Of 5049 infants in the validation population, 54 (1.1%) suffered from metabolic acidosis. After adjustment for incidence differences between the Dutch and Swedish cohorts, the prognostic models showed good calibration and moderate overall discrimination (C statistic 0.63, 95% confidence interval [CI] 0.55 to 0.71; and 0.64, 95% CI 0.55 to 0.72), for models 1 and 2, respectively).. External validation of the clinical prediction models for metabolic acidosis in Swedish infants showed good calibration and moderate discriminative ability. Updating of the models to enhance their predictive abilities seems indicated.

Topics: Acidosis; Amniotic Fluid; Cesarean Section; Diabetes Mellitus; Female; Gestational Age; Humans; Infant, Newborn; Labor Presentation; Labor, Induced; Meconium; Models, Statistical; Parity; Pregnancy; Pregnancy, High-Risk

Topics: Adolescent; Adult; Child; Child, Preschool; Cystic Fibrosis; Diabetes Mellitus; Female; Gastrointestinal Diseases; Humans; Infant; Infant, Newborn; Intestinal Obstruction; Liver Cirrhosis; Malabsorption Syndromes; Meconium; Puberty; Rectal Prolapse

Topics: Amniotic Fluid; Birth Weight; Creatinine; Diabetes Mellitus; Erythroblastosis, Fetal; Female; Fetus; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Meconium; Pregnancy; Pregnancy Complications

Topics: Adolescent; Anti-Bacterial Agents; Antibiotics, Antitubercular; Blood Protein Disorders; Bronchopneumonia; Child; Cystic Fibrosis; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diagnosis; Diagnosis, Differential; Diet; Diet Therapy; Electrolytes; Exercise Therapy; Gastroenterology; Humans; Infant; Infant, Newborn; Intestinal Obstruction; Liver Diseases; Meconium; Pancreatic Extracts; Sweat