morphine and Diabetes-Mellitus--Type-1

Topics: Adolescent; Adult; Autopsy; Child; Child, Preschool; Cystic Fibrosis; Diabetes Mellitus, Type 1; Female; Humans; Infant; Infant, Newborn; Infertility, Male; Intestinal Obstruction; Liver; Liver Cirrhosis, Biliary; Lung; Male; Meconium; Pancreas; Pregnancy; Sweat

Topics: Cystic Fibrosis; Diabetes Mellitus, Type 1; Fatal Outcome; Female; Humans; Ileal Diseases; Intestinal Obstruction; Intestines; Meconium; Radiography; Young Adult

Technological advances in genetics have made feasible and affordable large studies to identify genetic variants that cause or modify a trait. Genetic studies have been carried out to assess variants in candidate genes, as well as polymorphisms throughout the genome, for their associations with heritable clinical outcomes of cystic fibrosis (CF), such as lung disease, meconium ileus, and CF-related diabetes. The candidate gene approach has identified some predicted relationships, while genome-wide surveys have identified several genes that would not have been obvious disease-modifying candidates, such as a methionine sulfoxide transferase gene that influences intestinal obstruction, or a region on chromosome 11 proximate to genes encoding a transcription factor and an apoptosis controller that associates with lung function. These unforeseen associations thus provide novel insight into disease pathophysiology, as well as suggesting new therapeutic strategies for CF.

Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Genes, Modifier; Genetic Linkage; Genetic Markers; Genome-Wide Association Study; Homozygote; Humans; Liver Diseases; Lung Diseases; Mannose-Binding Lectins; Meconium; Mutation; Phenotype

Topics: Anemia; Body Weight; Chloramphenicol; Chlortetracycline; Cough; Cystic Fibrosis; Diabetes Mellitus, Type 1; Diet Therapy; Feces; Humans; Hunger; Hypoproteinemia; Infant; Infant, Newborn; Intestinal Obstruction; Meconium; Pancreatic Juice; Pancreatin; Physical Therapy Modalities; Prognosis; Rectal Prolapse; Sweat; Tooth Discoloration; Vomiting

Topics: Adolescent; Anti-Bacterial Agents; Antibiotics, Antitubercular; Blood Protein Disorders; Bronchopneumonia; Child; Cystic Fibrosis; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diagnosis; Diagnosis, Differential; Diet; Diet Therapy; Electrolytes; Exercise Therapy; Gastroenterology; Humans; Infant; Infant, Newborn; Intestinal Obstruction; Liver Diseases; Meconium; Pancreatic Extracts; Sweat