morphine has been researched along with Colonic-Diseases--Functional* in 2 studies
2 other study(ies) available for morphine and Colonic-Diseases--Functional
| Article | Year |
|---|---|
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.
Irritable bowel syndrome (IBS) is a pathopysiolocal condition characterized by abnormal bowel habits that are frequently accompanied by abdominal pain. Current therapy based on reducing high-amplitude GI contractions with nonselective muscarinic antagonists is limited in efficacy due to typical muscarinic side effects and provides no pain relief. We have previously found potent antinociceptive agents acting through muscarinic receptors. In the present work, new 1,2,5-thiadiazole-based structures with muscarinic activity have been evaluated both for activity as analgesics in the mouse withing assay and for activity in normalizing spontaneous cluster contractions in ferret jejunum as a model of IBS in humans. (5R,6R)-exo-6-[4-[(4,4,4-Trifluorobutyl)thio]-1,2,5-thiadiazol+ ++-3-yl] -1-azabicyclo[3.2.1]octane (35, LY316108/NNC11-2192) was found to offer an exceptional profile combining analgesic potency in mouse writhing (ED50 = 0.1 mg/kg) along with potency for normalization of GI motility (ED50 = 0.17 mg/kg). This combination of GI and analgesic potency suggests 35 as an excellent candidate for evaluation as a potential treatment of IBS. Topics: Analgesics, Non-Narcotic; Animals; Colonic Diseases, Functional; Drug Design; Ferrets; Gastrointestinal Motility; Male; Mice; Muscarinic Agonists; Nociceptors; Oxotremorine | 1997 |
Neonatal radiology. Functional immaturity of the large bowel in the newborn infant.
Topics: Colonic Diseases, Functional; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Intestinal Obstruction; Meconium; Megacolon; Pregnancy; Pregnancy in Diabetics; Radiography | 1975 |