morphine and Brain-Diseases

Intrapartum asphyxia is defined as metabolic acidemia measured at birth with pH less than 7.00 and base deficit greater or equal to 12 mmol/l. Neonatal complications of intrapartum asphyxia include multiorgan failure and neonatal encephalopathy. Most severe consequences are death and neurological or sensorial impairment. Cause of permanent neurological impairment can be attributed to intrapartum asphyxia if three criteria are met: intrapartum history of a threatening event with acute fetal heart rate deterioration, biological markers of asphyxia, neonatal encephalopathy. Moderate to severe neonatal encephalopathy in asphyxiated term infants is associated with a high risk of cerebral palsy (especially quadriplegic or dyskinetic type) and/or cognitive disorders. Prognosis of neonatal encephalopathy can be accurately assessed by MR imaging.

Topics: Acidosis; Apgar Score; Biomarkers; Brain Diseases; Cerebral Palsy; Female; Fetal Blood; Fetal Hypoxia; Heart Rate, Fetal; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Lactic Acid; Magnetic Resonance Imaging; Meconium; Multiple Organ Failure; Nervous System Diseases; Pregnancy; Ultrasonography

In this article, the authors examine whether indicators commonly used to recognized birth asphyxia are specific to asphyxial states, and whether these allow recognition of a severity of asphyxia sufficient to pose a risk of irreversible brain injury. Characteristics recognizable within the first hours after birth are focused on because these characteristics will be of most use in clinical decisions regarding use of potential new therapies for asphyxia.

Topics: Amniotic Fluid; Apgar Score; Asphyxia Neonatorum; Biomarkers; Blood Gas Analysis; Brain Diseases; Causality; Cerebral Palsy; Decision Making; Female; Heart Rate, Fetal; Humans; Infant, Newborn; Meconium; Predictive Value of Tests; Pregnancy; Pulmonary Gas Exchange; Severity of Illness Index

Topics: Abdomen; Brain Diseases; Cerebral Ventricles; Diagnosis, Differential; Enema; Female; Humans; Infant, Newborn; Intestinal Obstruction; Meconium

Topics: Amniotic Fluid; Brain Diseases; Fetal Diseases; Humans; Meconium

Topics: Brain Diseases; Candidiasis; Cerebral Aqueduct; Diseases in Twins; Female; Humans; Infant, Newborn; Meconium; Meningitis; Parenteral Nutrition; Peritonitis

Topics: Asphyxia; Asphyxia Neonatorum; Blood Glucose; Blood Viscosity; Brain Diseases; Female; Fetal Diseases; Fetal Growth Retardation; Humans; Hypocalcemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Inhalation; Kidney Diseases; Meconium; Polycythemia; Pregnancy; Prognosis; Syndrome

Topics: Asphyxia; Birth Weight; Brain Diseases; Child; Child, Preschool; Female; Follow-Up Studies; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Meconium; Motor Skills; Neurologic Examination; Pregnancy; Psychological Tests; Respiratory Distress Syndrome, Newborn