morphine and Asphyxia

Topics: Amniotic Fluid; Asphyxia; Blood Gas Analysis; Cesarean Section; Extraction, Obstetrical; Female; Fetal Diseases; Fetal Heart; Humans; Hypoxia; Infant, Newborn; Labor, Induced; Labor, Obstetric; Maternal-Fetal Exchange; Meconium; Phonocardiography; Pregnancy; Prenatal Care; Umbilical Cord

The passage of meconium during labor increased the chance of undesirable birth outcomes. The adverse effects of meconium are worsening in resource-limited countries. In Ethiopia, there is an argument concerning meconium's negative effects and management on pregnant women and their babies. Therefore, this study was intended to assess the adverse maternal and perinatal outcomes of meconium in term labor in the South Gondar Zone, Ethiopia.. A prospective cohort study was conducted using 580 laboring mothers (145 exposed and 435 nonexposed groups). A two-stage sampling method was implemented to get study subjects. The data were collected using an interviewer-administered structured questionnaire and a medical chart review. SPSS version 25 was used for data analysis. Chi-squared and Fisher's exact tests were used to compare the two groups' differences. The strength of the association was measured using relative risk with a 95% CI.. There was more operative delivery (28.3% versus 5.3%), puerperal sepsis (79.54% versus 2.06%), nonreassuring fetal heart rate pattern (29.7% versus 2.1%), meconium aspiration syndrome (7.58% versus 0.68%), neonatal sepsis (9% versus 4.1%), perinatal asphyxia (13.8% versus 7.6%), admission to the neonatal intensive care unit (23.4% versus 3.2%), and early neonatal deaths (4.8% versus 1.4%) among meconium stained groups as compared to the clear amniotic fluid groups.. Meconium-stained amniotic fluid significantly increased adverse maternal and perinatal outcomes in Ethiopia. The risk of perinatal asphyxia, nonreassuring fetal heart rate pattern, neonatal sepsis, meconium aspiration syndrome, admission to the NICU, early neonatal death, operative delivery, and puerperal sepsis were significantly higher in meconium-exposed groups. Special attention should be given to meconium-exposed mothers during the intrapartum period and in postnatal follow-up.

Topics: Amniotic Fluid; Asphyxia; Asphyxia Neonatorum; Ethiopia; Female; Hospitals; Humans; Infant, Newborn; Infant, Newborn, Diseases; Meconium; Meconium Aspiration Syndrome; Neonatal Sepsis; Pregnancy; Pregnancy Complications; Prospective Studies

Meconium-stained amniotic fluid is considered as the bad predictor of fetal outcome having significant perinatal morbidity and mortality. This study aimed to compare immediate fetal outcomes in meconium-stained amniotic fluid and clear amniotic fluid.. Hospital-based comparative observational study was conducted from a total of 204 women admitted in labour room at a tertiary level hospital. Among them, 102 were cases with meconium-stained amniotic fluid, and 102 were comparison groups with clear amniotic fluid. Fetal outcome was compared between these two groups.. The study findings revealed that majority (74.5%) in the study group had cesarean section as compared to 14.7% in the comparative group. More than one-fourth (26.5%) of the newborns in the study group had moderate to severe birth asphyxia, needed resuscitation (25.5%) and neonatal intensive care unit admission (25.5%) as compared to 3.9% from the comparative group. Maternal age (COR=0.34, 95%CI=0.15-0.81), color of amniotic fluid (COR=0.11; 95%CI=0.04-0.33), meconium consistency (COR=0.27; 95%CI=0.17-0.43), and mode of delivery (COR=0.36; 95%CI=0.17-0.79) were associated with birth asphyxia in bivariate analysis. Maternal age (AOR=2.66; 95%CI=1.04-6.81) and color of amniotic fluid (AOR=11.50; 95%CI=2.97-44.56) were associated with birth asphyxia in the multivariate analysis.. Meconium-stained amniotic fluid was associated with increased frequency of cesarean section and adverse fetal outcome with birth asphyxia being the major complications compared with clear amniotic fluid. Predictors of birth asphyxia were maternal age and color of amniotic fluid.

Topics: Amniotic Fluid; Asphyxia; Asphyxia Neonatorum; Cesarean Section; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Meconium; Nepal; Pregnancy; Pregnancy Complications

To investigate the hypothesis that meconium aspiration syndrome, the major hazard of meconium during labor, may be associated with superimposed fetal acute acidemia.. Umbilical artery blood gases were measured in 7816 term pregnancies with meconium in the amniotic fluid (AF) and the results were correlated with intrapartum and neonatal outcomes.. Sixty-nine (1%) infants developed meconium aspiration syndrome and 31 (45%) of these were in association with fetal acidemia at birth. Moreover, umbilical blood gas analysis and intrapartum events suggested that the fetal acidemia linked to meconium aspiration was an acute event rather than a long-duration process, which might be expected if meconium was itself a marker of an antecedent fetal asphyxial event.. Meconium in the AF may be a fetal environmental hazard when acidemia supervenes rather than solely a marker of preexisting fetal compromise leading to the release of meconium.

Topics: Acid-Base Imbalance; Amniotic Fluid; Asphyxia; Female; Fetal Blood; Fetal Diseases; Humans; Infant, Newborn; Meconium; Meconium Aspiration Syndrome; Pregnancy

Topics: Asphyxia; Fetal Diseases; Humans; Infant, Newborn; Meconium; Meconium Aspiration Syndrome; Models, Biological; Pharynx; Suction; Trachea

Topics: Asphyxia; Asphyxia Neonatorum; Blood Glucose; Blood Viscosity; Brain Diseases; Female; Fetal Diseases; Fetal Growth Retardation; Humans; Hypocalcemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Inhalation; Kidney Diseases; Meconium; Polycythemia; Pregnancy; Prognosis; Syndrome

Continuous fetal heart rate (FHR) monitoring and routine fetal scalp blood sampling was utilized in the evaluations of 366 fetuses during labor. One hundred and six patients had meconium in the amniotic fluid at some time during labor. A total of 26,110 uterine contractions were monitored during these 366 labors. The incidence of FHR patterns as a percentage of uterine contractions was calculated for the meconium and nonmeconium groups. Although there was a 3 1/2-fold increase in the incidence of low five-minute Apgar scores (less than 7) in the meconium group, signs of fetal distress were, with rare esception, not significantly different from those in the nonmeconium group. The presence of meconium in the amniotic fluid without signs of fetal asphyxia (late decelerations and acidosis) is not a sign of fetal distress and need not be an indication for active intervention. The combination of fetal asphyxia and meconium staining of the amniotic fluid, however, does enhance the potential for meconium aspiration and a poor neonatal outcome. Universal fetal heart rate monitoring and appropriate fetal acid-base evaluation is recommended for following patients with meconium in the amniotic fluid during labor.

Topics: Acid-Base Equilibrium; Adult; Amniotic Fluid; Apgar Score; Asphyxia; Blood; Delivery, Obstetric; Female; Fetal Diseases; Fetal Heart; Fetus; Heart Rate; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Inhalation; Labor, Obstetric; Meconium; Pregnancy; Scalp; Uterine Contraction

Topics: Asphyxia; Blood Transfusion; Color; Cyanosis; Female; Fetofetal Transfusion; Fetomaternal Transfusion; Gestational Age; Heart Defects, Congenital; Hematocrit; Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lung Diseases; Meconium; Oxygen Inhalation Therapy; Placenta Diseases; Positive-Pressure Respiration; Pregnancy; Resuscitation; Skin Manifestations

Topics: Asphyxia; Birth Weight; Brain Diseases; Child; Child, Preschool; Female; Follow-Up Studies; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Meconium; Motor Skills; Neurologic Examination; Pregnancy; Psychological Tests; Respiratory Distress Syndrome, Newborn

Topics: Acidosis; Amniotic Fluid; Asphyxia; Asphyxia Neonatorum; Endoscopy; Erythroblastosis, Fetal; Female; Fetal Diseases; Hemoglobinometry; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Meconium; Pregnancy; Pregnancy Complications; Serum Albumin, Radio-Iodinated; Spectrophotometry; Tromethamine