morphine and Abortion--Spontaneous

AIM. To revisit the role of first trimester homocysteine levels with the maternal and fetal outcome. METHODS. This was a cohort study comprising 100 antenatal women between 8 and 12 weeks of gestation. Serum homocysteine levels were checked after overnight fasting. RESULTS. There were significantly elevated homocysteine levels among women with prior history of hypertensive disorders of pregnancy and prior second or third trimester pregnancy losses. There was no significant difference in homocysteine levels among women with previous gestational diabetes mellitus, preterm deliveries, or fetal malformations. Homocysteine levels were significantly elevated in those who developed hypertensive disorder of pregnancy, oligohydramnios, and meconium stained amniotic fluid, had a pregnancy loss, or delivered a low birth weight baby. There was no significant difference in homocysteine levels for those who developed gestational diabetes mellitus. CONCLUSIONS. Increased first trimester serum homocysteine is associated with history of pregnancy losses, hypertensive disorders of pregnancy, and preterm birth. This is also associated with hypertensive disorders of pregnancy, pregnancy loss, oligohydramnios, meconium stained amniotic fluid, and low birth weight in the current pregnancy. This trial is registered with ClinicalTrials.gov CTRI/2013/02/003441.

Topics: Abortion, Spontaneous; Adult; Amniotic Fluid; Cohort Studies; Diabetes, Gestational; Female; Homocysteine; Humans; Hypertension, Pregnancy-Induced; Infant, Low Birth Weight; Meconium; Oligohydramnios; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Young Adult

The purpose of this study was to evaluate the obstetric outcomes and pathologic findings in women with sickle cell trait.. In this retrospective case control study, pregnant women with sickle cell trait were studied over a 4-year period (2001-2005). The women who were delivered at > 16 weeks of gestation were compared with a cohort group of subjects with normal hemoglobin levels, and the placentas were sent for pathologic evaluation.. A total of 180 pregnancies were studied with a like number of control patients. Subjects who had sickle cell trait demonstrated shorter average duration of pregnancy (233 +/- 45 days vs 255 +/- 34 days; P < .001) and lower birth weight (2114 +/- 1093 g vs 2672 +/- 942 g; P < .001). The rate of fetal death was significantly higher among study group patients (3.5% vs 9.7%; P = .015) when compared with the control group. Additionally, in study women, acute ascending amniotic infection and meconium histiocytosis were noted much more frequently. Sickling in the intervillous space and decidual vessels that were not associated with artifactual change was also found among patients sickle cell trait.. Patients with sickle cell trait appear to be at increased risk for fetal loss compared with women with normal hemoglobin levels, and placental abnormalities may play a causal role.

Topics: Abortion, Spontaneous; Acute Disease; Amnion; Birth Weight; Case-Control Studies; Delivery, Obstetric; Female; Fetal Death; Fetal Diseases; Fetal Viability; Gestational Age; Histiocytosis; Humans; Incidence; Infections; Meconium; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Complications, Infectious; Pregnancy Trimester, First; Retrospective Studies; Sickle Cell Trait

The characteristics of 94 patients with meconium stained amniotic fluid diagnosed during labour in the Prince of Wales Hospital, Hong Kong, from July to August 1984, were analysed. The incidence was 21.4% of deliveries. These patients were compared to a group of non-meconium patients (349 cases) in demographic and obstetric aspects. Patients in low social class and patients with antenatal and medical complications did not have a higher incidence of meconium staining of amniotic fluid. However, a history of previous spontaneous or induced abortion was significantly more common in the meconium group. The labour performance of these patients and the perinatal outcome are discussed.

Topics: Abortion, Induced; Abortion, Spontaneous; Adult; Amniotic Fluid; Female; Gestational Age; Hong Kong; Humans; Infant, Newborn; Meconium; Pregnancy; Socioeconomic Factors

Topics: Abortion, Induced; Abortion, Spontaneous; Anal Canal; Defecation; Female; Fetus; Gestational Age; Humans; Intestinal Mucosa; Meconium; Pregnancy