morphine-6-glucuronide and Epilepsy

morphine-6-glucuronide has been researched along with Epilepsy* in 1 studies

Other Studies

1 other study(ies) available for morphine-6-glucuronide and Epilepsy

Article	Year
Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain. The Journal of toxicological sciences, 2003, Volume: 28, Issue:5 3H-Morphine at physiologic concentration was metabolized in vitro to its 3- and 6-glucuronides by human brain homogenate. Recombinant UGT2B7, one of the UDP-glucuronosyltransferase (UGT) isoforms, is able to glucuronidate the 3- and 6-hydroxy groups of morphine at nanomolar concentrations. These results suggest that endogenous morphine is converted to its 6-glucuronide, a more highly analgesic substance than the parent compound, to suppress effectively pain symptoms in humans. Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Epilepsy; Glucuronosyltransferase; Humans; In Vitro Techniques; Morphine; Morphine Derivatives; Opioid Peptides; Temporal Lobe; Tritium	2003

Article

Year

Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain.

The Journal of toxicological sciences, 2003, Volume: 28, Issue:5

3H-Morphine at physiologic concentration was metabolized in vitro to its 3- and 6-glucuronides by human brain homogenate. Recombinant UGT2B7, one of the UDP-glucuronosyltransferase (UGT) isoforms, is able to glucuronidate the 3- and 6-hydroxy groups of morphine at nanomolar concentrations. These results suggest that endogenous morphine is converted to its 6-glucuronide, a more highly analgesic substance than the parent compound, to suppress effectively pain symptoms in humans.

Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Epilepsy; Glucuronosyltransferase; Humans; In Vitro Techniques; Morphine; Morphine Derivatives; Opioid Peptides; Temporal Lobe; Tritium

2003