morphinans and Hypertension

Opioid compounds injected intracisternally in rats induce a centrally-mediated increase in blood pressure. In the present study, the intracisternal injection of an antagonist of opioid compounds, diprenorphine was examined. Diprenorphine caused a similar blood pressure decrease in spontaneously hypertensive rats and normotensive control Wistar Kyoto rats both in young and adult animals. This represents an important argument concerning a role of endogenous opioids in blood pressure control in anaesthetized rats but suggests that brain stem endogenous opioids may not be involved in the mechanism of hypertension.

Topics: Animals; Blood Pressure; Central Nervous System; Cisterna Magna; Diprenorphine; Heart Rate; Hypertension; Injections; Injections, Intravenous; Morphinans; Rats; Rats, Inbred Strains

Topics: Acepromazine; Analgesics; Animals; Blood Pressure; Bradycardia; Cyclopropanes; Dog Diseases; Dogs; Drug Combinations; Female; Heart Rate; Horse Diseases; Horses; Hypertension; Hypotension; Injections, Intravenous; Male; Morphinans; Narcotic Antagonists; Neuroleptanalgesia; Respiration; Tremor; Vagotomy; Venous Pressure

Topics: Adult; Ataxia; Auditory Perception; Blepharoptosis; Cognition Disorders; Hallucinations; Humans; Hypertension; Hypotension; Male; Morphinans; Speech Disorders; Substance Withdrawal Syndrome; Thebaine; Tinnitus; Visual Perception

Topics: Animals; Blood Pressure; Cardiac Output; Cats; Cycloheximide; Depression, Chemical; Drug Antagonism; Drug Tolerance; Electrocardiography; Female; Hypertension; Male; Morphinans; Morphine; Norepinephrine; Rats; Vascular Resistance