morphinans has been researched along with Hepatitis--Animal* in 1 studies
1 other study(ies) available for morphinans and Hepatitis--Animal
Article | Year |
---|---|
Protection by sinomenine against endotoxin-induced fulminant hepatitis in galactosamine-sensitized mice.
Sinomenine, an epimorphinan alkaloid, was tested for protecting hepatitis induced by lipopolysaccharide (LPS) in galactosamine (GalN)-sensitized mice. Sinomenine protected against the hepatic injuries in the dose range of 10-100 mg/kg in a dose-dependent manner and suppressed the production of tumor necrosis factor (TNF), which appeared in serum earlier than aminotransferases in GalN/LPS-treated mice. Sinomenine significantly suppressed the in vitro production of superoxide anion and hydrogen peroxide in the macrophage cultures stimulated with phorbol 12-myristate acetate. It is discussed that sinomenine prevents GalN/LPS-treated hepatic failure by suppressing TNF production and/or reactive oxygen generation. Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Galactosamine; Hepatitis, Animal; Lipopolysaccharides; Macrophage Activation; Male; Mice; Mice, Inbred ICR; Morphinans; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 1994 |