morphinans and Fissure-in-Ano

To observe the clinical effect and experimental result of long-acting analgesic in the treatment of anorectal post-operational pain.. Analysing the pathological features of anorectal post-operational pain, and select the Radix Stephana Tetrandra, which could disperse pathogenic Wind and dampness, relieve spasm and pain, as the major component. The authors extracted Sinomenine from the Stephana and by mixing with methylene blue and bupivacaine hydrochloride, an injection was prepared. Three groups were in the clinical observation: Long-acting analgesic group (102 cases), routine treatment group (80 cases) and the control group treated by Tramal (30 cases). The curative effect was observed and animal experiment was conducted.. The total analgesic rate of the long-acting analgesia was 56.86%. The clinical effect was better than using Bupivacaini hydrochloride or Tramal alone (P < 0.05). It was shown in experiment that long-acting analgesic had obvious effects of topical analgesic and muscle relaxant.. Long-acting analgesic has significant effect in relieving the anorectal post-operational pain.

Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drugs, Chinese Herbal; Female; Fissure in Ano; Hemorrhoids; Humans; Male; Middle Aged; Morphinans; Pain, Postoperative