morphinans and Dry-Eye-Syndromes

To investigate the effect of topical sinomenine (SIN) on ocular surface damage in experimental dry eye in mice.. Experimental dry eye was created using scopolamine hydrobromide in female C57BL/6 mice. Eye drops consisting of 0.05%, or 0.1% SIN or phosphate-buffered saline (PBS) were applied to the experimental dry eye in mice. Tear product and corneal staining scores were measured at 7 and 14 days after treatment. Interleukin (IL)-1β and tumour necrosis factor (TNF)-α levels in the SIN groups at 14 days after treatment were compared with those of other groups.. Mice treated with 0.05% or 0.1% SIN showed a significant improvement in tear product and corneal irregularity compared to the control and PBS-treated groups. A significant decrease in the levels of IL-1βand TNF-α was observed in the 0.05% and 0.01% SIN-treated groups.. Topical SIN eye drop application can effectively improve clinical signs and decrease inflammation in the ocular surface, and alleviate ocular surface damage in dry eye.

Topics: Animals; Cornea; Disease Models, Animal; Dry Eye Syndromes; Female; Interleukin-1beta; Mice, Inbred C57BL; Morphinans; Ophthalmic Solutions; Scopolamine; Tears; Tumor Necrosis Factor-alpha