morphinans and Agranulocytosis

BACKGROUND Sinomenine hydrochloride is an alkaloid that is extracted from the Chinese herbal plant Sinomenium acutum, and is used as a herbal medicine in the treatment or rheumatic disease. This report is the first to describe a case of sinomenine hydrochloride-induced agranulocytosis. CASE REPORT A 44-year-old woman with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) was treated with sinomenine hydrochloride and developed agranulocytosis with a neutrophil count of 0.01×10^9/L. She subsequently developed an opportunistic bacterial infection. Bone marrow aspiration showed a severe reduction in the proportion of mature granulocytes. The patient discontinued sinomenine hydrochloride therapy and was treated with granulocyte colony-stimulating factor (G-CSF) and antibiotics. The patient showed a return to normal granulocyte levels within ten days of discontinuing treatment with sinomenine hydrochloride. CONCLUSIONS The findings of this case report show that monitoring of bone marrow function and granulocyte levels should be performed during treatment with sinomenine hydrochloride.

Topics: Adult; Agranulocytosis; Antirheumatic Agents; Drugs, Chinese Herbal; Female; Humans; Morphinans

Topics: Acetanilides; Agranulocytosis; Analgesics; Anesthesia, Dental; Aspirin; Blood Coagulation; Caffeine; Codeine; Drug Combinations; Flufenamic Acid; Gastrointestinal Hemorrhage; Heterocyclic Compounds; Humans; Indomethacin; Mefenamic Acid; Morphinans; Mouth Diseases; ortho-Aminobenzoates; Phenacetin

Topics: Adrenal Cortex Hormones; Agranulocytosis; Anti-Bacterial Agents; Ascorbic Acid; Blood Transfusion; Drug Hypersensitivity; gamma-Globulins; Humans; Morphinans