morin has been researched along with Tachycardia--Ventricular* in 1 studies
1 other study(ies) available for morin and Tachycardia--Ventricular
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Evaluating the possible role of mitochondrial ATP-sensitive potassium channels in the cardioprotective effects of morin in the isolated rat heart.
During heart ischemia, the lack of oxygen in the myocardial cells causes pH and ion disturbances and cell death through opening mitochondrial permeability transition pores (mPTP). Considering the inhibitory effects of mitochondrial ATP-dependent potassium channels (mt-K. Isolated rat hearts were perfused by Krebs-Henseleit solution enriched with the morin (0.25, 0.5 and 1 mg/L) or 5-hydroxydecanoate (5-HD, a mt-K. Our findings demonstrated that morin reduced the infarct size. Also, morin perfusion could remarkably prevent the malondialdehyde over-production during ischemia. Total ventricular ectopic beats had the same significant changes as the malondialdehyde level, in both ischemia and reperfusion phases. Morin could also relatively improve the ischemia-induced hemodynamic dysfunction. All mentioned protective effects of morin were reversed by concomitant perfusion of 5-HD.. Morin has protective effects against ischemic hearts through anti-oxidative effects. It also suggests a link between the cardioprotective effects of morin and mt-K Topics: Animals; Blood Pressure; Cardiotonic Agents; Flavonoids; Heart; Heart Ventricles; Hemodynamics; KATP Channels; L-Lactate Dehydrogenase; Male; Malondialdehyde; Mitochondria, Heart; Myocardial Infarction; Perfusion; Rats, Wistar; Tachycardia, Ventricular | 2021 |