mordenite and Hemolysis

mordenite has been researched along with Hemolysis* in 2 studies

Other Studies

2 other study(ies) available for mordenite and Hemolysis

Article	Year
In vitro and in vivo tests for determination of the pathogenicity of quartz, diatomaceous earth, mordenite and clinoptilolite. The Annals of occupational hygiene, 2000, Volume: 44, Issue:1 The effects of samples of crystalline quartz, diatomaceous earth, mordenite and clinoptilolite were investigated in vitro (as concerns erythrocyte haemolysis and lactate dehydrogenase (LDH) release from peritoneal macrophages) and in vivo (on LDH, protein and phospholipids in rat bronchoalveolar lavage (BAL), and phospholipids in rat lung tissue). The respirable mineral samples were instilled intratracheally. Determinations in the BAL were carried out after 15, 60 and 180 days, and in the lung tissue after 90, 180 and 360 days. Quartz DQ and quartz FQ induced acute, subacute and chronic inflammation and progressive fibrosis. However, due to the Al2O3 contamination on the surface of the particles quartz FQ caused a delayed response in vivo. Diatomaceous earth produced acute/subacute inflammation that gradually became more moderate after 60 days. Clinoptilolite was inert, whereas the other zeolite sample, mordenite, was cytotoxic in vivo. The reason for this was presumably the needle and rod-shaped particles in the mordenite samples. The investigation revealed that different in vitro and in vivo methods canprovide valuable data concerning the pulmonary toxicity of minerals. Topics: Aluminum Silicates; Animals; Bronchoalveolar Lavage; Diatomaceous Earth; Erythrocytes; Hemolysis; Inflammation; Inhalation Exposure; L-Lactate Dehydrogenase; Lung; Macrophages; Male; Mining; Occupational Exposure; Phospholipids; Pulmonary Fibrosis; Quartz; Rats; Rats, Sprague-Dawley; Zeolites	2000
[Biological activity of Bulgarian zeolite rocks]. Problemi na khigienata, 1985, Volume: 10 An evaluation of the biological activity of Bulgarian zeolite rocks was made by the methods in vivo and in vitro. The results pointed out to specific biological effect--cytotoxic and fibrogenic--most strongly expressed for clinoptilolite followed by mordenite and erionite. The clinoptilolite is characterized by strong cytotoxic effect in comparison with dust of calibrated quartz DQ-12 which confirms the lack of correlation between cytotoxicity and fibrogenicity for some types of dust. On the basis of the results a temporary hygienic norm for clinoptilolite dust--2 mg/m3 is proposed. Topics: Aluminum Silicates; Animals; Bulgaria; Dust; Hemolysis; In Vitro Techniques; Lung; Maximum Allowable Concentration; Pulmonary Fibrosis; Quartz; Rats; Time Factors; United States; Zeolites	1985

Article

Year

In vitro and in vivo tests for determination of the pathogenicity of quartz, diatomaceous earth, mordenite and clinoptilolite.

The Annals of occupational hygiene, 2000, Volume: 44, Issue:1

The effects of samples of crystalline quartz, diatomaceous earth, mordenite and clinoptilolite were investigated in vitro (as concerns erythrocyte haemolysis and lactate dehydrogenase (LDH) release from peritoneal macrophages) and in vivo (on LDH, protein and phospholipids in rat bronchoalveolar lavage (BAL), and phospholipids in rat lung tissue). The respirable mineral samples were instilled intratracheally. Determinations in the BAL were carried out after 15, 60 and 180 days, and in the lung tissue after 90, 180 and 360 days. Quartz DQ and quartz FQ induced acute, subacute and chronic inflammation and progressive fibrosis. However, due to the Al2O3 contamination on the surface of the particles quartz FQ caused a delayed response in vivo. Diatomaceous earth produced acute/subacute inflammation that gradually became more moderate after 60 days. Clinoptilolite was inert, whereas the other zeolite sample, mordenite, was cytotoxic in vivo. The reason for this was presumably the needle and rod-shaped particles in the mordenite samples. The investigation revealed that different in vitro and in vivo methods canprovide valuable data concerning the pulmonary toxicity of minerals.

Topics: Aluminum Silicates; Animals; Bronchoalveolar Lavage; Diatomaceous Earth; Erythrocytes; Hemolysis; Inflammation; Inhalation Exposure; L-Lactate Dehydrogenase; Lung; Macrophages; Male; Mining; Occupational Exposure; Phospholipids; Pulmonary Fibrosis; Quartz; Rats; Rats, Sprague-Dawley; Zeolites

2000

[Biological activity of Bulgarian zeolite rocks].

Problemi na khigienata, 1985, Volume: 10

An evaluation of the biological activity of Bulgarian zeolite rocks was made by the methods in vivo and in vitro. The results pointed out to specific biological effect--cytotoxic and fibrogenic--most strongly expressed for clinoptilolite followed by mordenite and erionite. The clinoptilolite is characterized by strong cytotoxic effect in comparison with dust of calibrated quartz DQ-12 which confirms the lack of correlation between cytotoxicity and fibrogenicity for some types of dust. On the basis of the results a temporary hygienic norm for clinoptilolite dust--2 mg/m3 is proposed.

Topics: Aluminum Silicates; Animals; Bulgaria; Dust; Hemolysis; In Vitro Techniques; Lung; Maximum Allowable Concentration; Pulmonary Fibrosis; Quartz; Rats; Time Factors; United States; Zeolites

1985