montirelin and Cognition-Disorders

montirelin has been researched along with Cognition-Disorders* in 1 studies

Other Studies

1 other study(ies) available for montirelin and Cognition-Disorders

Article	Year
NS-3 (CG3703), an analog of thyrotropin-releasing hormone, ameliorates cognitive impairment in rats. Pharmacology, biochemistry, and behavior, 1995, Volume: 50, Issue:4 The effects of thyrotropin-releasing hormone (TRH) and its analog, N-[[(3R,6R)-6-methyl-5-oxo-thiomorpholinyl] carbonyl]-L-histidyl-L- prolinamide tetrahydrate (NS-3, CG3703) on disturbance of memory of a passive avoidance response (PAR) and an escape response in rats were investigated. NS-3 improved amnesia caused by scopolamine, electroconvulsive shock (ECS), and cycloheximide (CXM), but TRH improved only the ECS-induced amnesia. NS-3 reversed learning deficits caused by hypercapnia, but TRH had no effect. These differences in the effect between NS-3 and TRH may be due to their biological half-life in rat plasma. These results suggest that NS-3 possesses more potent antiamnestic effects than TRH in rats. Topics: Amino Acid Sequence; Animals; Avoidance Learning; Cognition Disorders; Cycloheximide; Electroshock; Hypercapnia; Male; Molecular Sequence Data; Rats; Rats, Wistar; Scopolamine; Thyrotropin-Releasing Hormone	1995

Article

Year

NS-3 (CG3703), an analog of thyrotropin-releasing hormone, ameliorates cognitive impairment in rats.

Pharmacology, biochemistry, and behavior, 1995, Volume: 50, Issue:4

The effects of thyrotropin-releasing hormone (TRH) and its analog, N-[[(3R,6R)-6-methyl-5-oxo-thiomorpholinyl] carbonyl]-L-histidyl-L- prolinamide tetrahydrate (NS-3, CG3703) on disturbance of memory of a passive avoidance response (PAR) and an escape response in rats were investigated. NS-3 improved amnesia caused by scopolamine, electroconvulsive shock (ECS), and cycloheximide (CXM), but TRH improved only the ECS-induced amnesia. NS-3 reversed learning deficits caused by hypercapnia, but TRH had no effect. These differences in the effect between NS-3 and TRH may be due to their biological half-life in rat plasma. These results suggest that NS-3 possesses more potent antiamnestic effects than TRH in rats.

Topics: Amino Acid Sequence; Animals; Avoidance Learning; Cognition Disorders; Cycloheximide; Electroshock; Hypercapnia; Male; Molecular Sequence Data; Rats; Rats, Wistar; Scopolamine; Thyrotropin-Releasing Hormone

1995