montelukast and Zika-Virus-Infection

Flavivirus, such as Dengue Virus (DENV) and Zika virus (ZIKV), infects millions of people and cause the death of thousands of people every year. Despite many efforts, there is no approved anti-flaviviral treatment available. In particular, some antiflavivirus compounds were investigated the cellular activities of DENV and ZIKV, but lacking the exploration of specific target enzyme, thereby resulting in the hindrance of structure-based drug design. One example is Montlukast, which was found to inhibit the replicon replication in DENV and ZIKV infected cells, with EC

Topics: Acetates; Antiviral Agents; Cyclopropanes; Enzyme Inhibitors; Flavivirus; Humans; Peptide Hydrolases; Protease Inhibitors; Quinolines; Sulfides; Viral Nonstructural Proteins; Zika Virus; Zika Virus Infection