montelukast has been researched along with Overweight* in 2 studies
1 review(s) available for montelukast and Overweight
Article | Year |
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Body mass index and response to asthma therapy: fluticasone propionate/salmeterol versus montelukast.
We studied the relationship between body mass index (BMI) on responses to asthma therapy using a retrospective analysis of four previously reported clinical trials. Fluticasone propionate (FP)/salmeterol via Diskus 100/50 microg twice daily and montelukast (MON) 10 mg daily were compared. BMI was classified as underweight (less than 20 kg/m(2)), normal (20-24.9 kg/m(2)), overweight (25-29.9 kg/m(2)), obese-1 (30-34.9 kg/m(2)), obese-2 (35-39.9 kg/m(2)), or obese-3 (at least 40 kg/m(2)). Outcomes assessed included forced expiratory volume in one second (FEV(1)), asthma symptom score, and albuterol use. FP/salmeterol produced greater improvements compared to MON in each of the asthma outcomes studied over the entire BMI range at the week-12 endpoint, with statistically significant differences noted among normal, overweight, obese-1, and obese-3 subjects. The within-treatment responses to FP/salmeterol across BMI ranges at the week-12 endpoint was statistically significantly greater in normal compared to obese-3 for FEV(1) and albuterol use, and in overweight compared to the obese-3 for each outcome studied. The within-treatment comparisons of MON across BMI ranges were significant for albuterol use in normal and underweight compared to obese-3 at the week-12 endpoint. Compared to subjects with normal BMI, the onset to peak FEV(1) may require longer treatment exposure in the very obese. Treatment responses to FP/salmeterol were consistently greater compared to MON and persisted at higher BMI. Topics: Acetates; Adult; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Body Mass Index; Cyclopropanes; Double-Blind Method; Drug Combinations; Female; Fluticasone-Salmeterol Drug Combination; Forced Expiratory Volume; Humans; Male; Middle Aged; Multicenter Studies as Topic; Obesity; Overweight; Quinolines; Randomized Controlled Trials as Topic; Sulfides; Time Factors; Treatment Outcome | 2010 |
1 trial(s) available for montelukast and Overweight
Article | Year |
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Effectiveness of montelukast in overweight and obese atopic asthmatics.
Topics: Acetates; Adolescent; Anti-Asthmatic Agents; Asthma; Child; Cyclopropanes; Double-Blind Method; Female; Humans; Male; Obesity; Overweight; Prospective Studies; Quinolines; Sulfides | 2017 |