montelukast has been researched along with Nociceptive-Pain* in 1 studies
1 other study(ies) available for montelukast and Nociceptive-Pain
| Article | Year |
|---|---|
Montelukast, a cysteinyl leukotriene receptor antagonist, exerts local antinociception in animal model of pain through the L-arginine/nitric oxide/cyclic GMP/K
The leukotrienes are inflammatory mediators. In the present study, the analgesic role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible involvement of L-arginine/NO/cGMP/K. The local administration of montelukast into the hind paw produced dose-related analgesia during both phases of the formalin test. Furthermore, pre-treatment with L-NAME, methylene blue, and glibenclamide prevented montelukast (10 μg/paw)-induced antinociception in both early and late phases of the test. Moreover, the local L-arginine and diazoxide before the sub-effective dose of montelukast (3 μg/paw) produced an analgesic effect. Also, local GW-9662 blocked antinociception induced by montelukast plus pioglitazone (10 μg/paw).. In conclusion, montelukast produced peripheral analgesia through PPARγ receptors and activation of the L-arginine/NO/cGMP/K Topics: Acetates; Analgesia; Analgesics; Animals; Arginine; Behavior, Animal; Cyclic GMP; Cyclopropanes; Disease Models, Animal; KATP Channels; Leukotriene Antagonists; Male; Nitric Oxide; Nociceptive Pain; PPAR gamma; Quinolines; Rats, Wistar; Signal Transduction; Sulfides | 2021 |